ALEXIS Biochemicals: (-)-Menthol

You are here: Product Lines > Signal Transduction > Ion Channels & Transporters / Related Products > Transient Receptor Potential [TRP] Channels > TRP Channels Other Products

ALX-400-045

Revised 31-Aug-07

2-Aminoethoxydiphenyl borate
SYNONYMS	2-APB
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Ca2+ Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-045-M100		100 mg	30.00 USD

Product Specification

FORMULA:	C₁₄H₁₆BNO
MW:	225.1
CAS NUMBER:	524-95-8
RTECS:	ED6150000
PURITY:	≥98%
APPEARANCE:	White crystalline solid.
SOLUBILITY:	Soluble in DMSO, dimethyl formamide or 100% ethanol; also soluble in PBS, pH 7.2.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for 2 months at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Hygroscopic. Packaged under inert gas.

Product Description

Cell permeable modulator of Ins(1,4,5)-P₃-induced Ca²⁺ release. A prototype drug for a group of structurally related calcium channel blockers in human platelets. Has been shown, in the absence of other stimuli, to activate TRPV1, V2 and V3, but not TRPV4, V5 and V6 expressed in HEK 293 cells.

Product Specific Literature References

2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release: T. Maruyama, et al.; J. Biochem. 122, 498 (1997) Abstract
Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB). 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites: J.G. Bilmen, et al.; Eur. J. Biochem. 269, 3678 (2002) Abstract
2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release: M.D. Bootman, et al.; FASEB J. 16, 1145 (2002) Abstract
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives: H. Watanabe, et al.; J. Biol. Chem. 277, 13569 (2002) Abstract
2-Aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2 and TRPV3: H.Z. Hu, et al.; J. Biol. Chem. 279, 35741 (2004) Abstract; Full Text
TRPV4 calcium entry channel: a paradigm for gating diversity: B. Nilius, et al.; Am. J. Physiol. Cell Physiol. 286, C195 (2004) Abstract
2APB- and JTV519(K201)-sensitive micro Ca2+ waves in arrhythmogenic Purkinje cells that survive in infarcted canine heart: P.A. Boyden, et al.; Heart Rhythm 1, 218 (2004) Abstract
Inhibition of glutamate-induced delayed calcium deregulation by 2-APB and La3+ in cultured cortical neurones: C. Chinopoulos, et al.; J. Neurochem. 91, 471 (2004) Abstract
2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3: M.K. Chung, et al.; J. Neurosci. 24, 5177 (2004) Abstract; Full Text
The blocking of capacitative calcium entry by 2-aminoethyl diphenylborate (2-APB) and carboxyamidotriazole (CAI) inhibits proliferation in Hep G2 and Huh-7 human hepatoma cells: A. Enfissi, et al.; Cell Calcium 36, 459 (2004) Abstract
Induction of cholestasis in the perfused rat liver by 2-aminoethyl diphenylborate, an inhibitor of the hepatocyte plasma membrane Ca2+ channels: R.B. Gregory, et al.; J. Gastroenterol. Hepatol. 19, 1128 (2004) Abstract
2-aminoethoxydiphenyl borate inhibits agonist-induced Ca2+ signals by blocking inositol trisphosphate formation in acutely dissociated mouse pancreatic acinar cells: J. Wu, et al.; Pflugers Arch. 448, 592 (2004) Abstract
2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels: Q. Gu, et al.; Am. J. Physiol. Lung Cell Mol. Physiol. 288, L392 (2005) Abstract
2-Aminoethoxydiphenyl borate perturbs hormone-sensitive calcium stores and blocks store-operated calcium influx pathways independent of cytoskeletal disruption in human A549 lung cancer cells: S. Padar, et al.; Biochem. Pharmacol. 69, 1177 (2005) Abstract
Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect: S.Z. Xu, et al.; Br. J. Pharmacol. 145, 405 (2005) Abstract; Full Text
2-Aminoethoxydiphenyl borate (2-APB) stimulates a conformationally coupled calcium release pathway in the NG115-401L neuronal cell line: D.D. Bose & D.W. Thomas; Neuropharmacology 50, 532 (2006) Abstract
2-aminoethoxydiphenyl borate as a prototype drug for a group of structurally related calcium channel blockers in human platelets: Y. Dobrydneva, et al.; Mol. Pharmacol. 69, 247 (2006) Abstract

Further Categories Containing This Product:

TRPV2, TRPV3, TRPV4 / Related Products • TRPV1 Agonists and Antagonists / Related Products • TRP Channels Other Products

ALX-420-037

Revised 11-Feb-08

Icilin
SYNONYMS	AG 3-5 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Neuroactive Agents Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-037-M001		1 mg	10.00 USD
ALX-420-037-M005		5 mg	32.00 USD
ALX-420-037-M025		25 mg	140.00 USD

Product Specification

FORMULA:	C₁₆H₁₃N₃O₄
MW:	311.3
CAS NUMBER:	36945-98-9
PURITY:	≥98% (¹H-NMR)
APPEARANCE:	Light yellow solid.
SOLUBILITY:	Soluble in DMSO (100mM).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Cooling agent. Strongly activates TRPM8 (cold menthol receptor 1; CMR1) and TRPA1 (at 10- to 100-fold higher concentration). Induces currents in TRPM8 expressing HEK 293 cells (EC₅₀=0.36mM) more potently than menthol (Prod. No. ALX-420-042) or low temperatures.

Product Specific Literature References

AG-3-5: a chemical producing sensations of cold: E.T. Wei and D.A. Seid; J. Pharm. Pharmacol. 35, 110 (1983) Abstract
Identification of a cold receptor reveals a general role for TRP channels in thermosensation: D.D. McKemy, et al.; Nature 416, 52 (2002) Abstract
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH: D.A. Andersson, et al.; J. Neurosci. 24, 5364 (2004) Abstract; Full Text
The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel: H.H. Chuang, et al.; Neuron 43, 859 (2004) Abstract
Icilin activates the {delta}-subunit of the human epithelial Na+ channel.: H. Yamamura; Mol. Pharmacol. 68, 1142 (2005) Abstract
Sensing with TRP channels: T. Voets, et al.; Nat. Chem. Biol. 1, 85 (2005), Review Abstract
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain: C.J. Proudfoot, et al.; Curr. Biol. 16, 1591 (2006) Abstract

Related Products

ALX-420-042	(-)-Menthol
ALX-420-041	WS-12

Further Categories Containing This Product:

TRP Channels Other Products

ALX-420-042

Revised 18-Jun-08

(-)-Menthol
SYNONYMS	(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol 5-Methyl-2-(1-methylethyl)cyclohexanol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Neurological Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-042-M025		25 mg	30.00 USD
ALX-420-042-M100		100 mg	75.00 USD

Product Specification

FORMULA:	C₁₀H₂₀O
MW:	156.3
CAS NUMBER:	2216-51-5
MERCK INDEX:	14: 5837
RTECS:	OT0700000
PURITY:	≥98% (sum of enantiomers, GC)
APPEARANCE:	Colorless to white crystalline solid.
SOLUBILITY:	Soluble in 100% ethanol or methanol (100mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Limited shelf life.
HAZARD:	IRRITANT.
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Cooling agent. Strongly activates TRPM8 (cold menthol receptor 1; CMR1) and TRPA1.

Product Specific Literature References

Identification of a cold receptor reveals a general role for TRP channels in thermosensation: D.D. McKemy, et al.; Nature 416, 52 (2002) Abstract
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH: D.A. Andersson, et al.; J. Neurosci. 24, 5364 (2004) Abstract; Full Text
Sensing with TRP channels: T. Voets, et al.; Nat. Chem. Biol. 1, 85 (2005), Review Abstract
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain: C.J. Proudfoot, et al.; Curr. Biol. 16, 1591 (2006) Abstract
Bimodal action of menthol on the transient receptor potential channel TRPA1: Y. Karashima, et al.; J. Neurosci. 27, 9874 (2007) Abstract
The menthol receptor TRPM8 is the principal detector of environmental cold: D.M. Bautista, et al.; Nature 448, 204 (2007) Abstract