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ALX-152-001
Revised 12-Sep-05
Big Endothelin-1 (1-38) (human)
SYNONYMS
Big ET-1 (1-38) (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-001-PC01
0.1 mg*
100.00 USD
ALX-152-001-PC05
0.5 mg*
400.00 USD
ALX-152-001-P001
1 mg*
650.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
189
H
282
N
48
O
56
S
5
MW:
4283.0
CAS NUMBER:
121014-53-7
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥98% (HPLC)
SOLUBILITY:
Soluble in water; also soluble in 0.5% acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin:
Y. Itoh, et al.; FEBS Lett.
231
, 440 (1988)
Abstract
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo:
T. Kashiwabara, et al.; FEBS Lett.
247
, 73 (1989)
Abstract
Further Categories Containing This Product:
Peptides
ALX-152-007
Revised 14-Dec-04
Big Endothelin-1 (1-39) (bovine)
SYNONYMS
Big ET-1 (1-39) (bovine)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-007-PC01
0.1 mg*
140.00 USD
ALX-152-007-PC05
0.5 mg*
560.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
192
H
287
N
49
O
58
S
5
MW:
4370.0
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Cloning and sequencing of a bovine preproendothelin cDNA:
G.J. Price & L. Malone; Nucl. Acid Res.
18
, 3658 (1990)
Abstract
Further Categories Containing This Product:
Peptides
ALX-152-002
Revised 26-Nov-04
Big Endothelin-1 (1-39) (pig)
SYNONYMS
Big ET-1 (1-39) (pig)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-002-PC01
0.1 mg*
140.00 USD
ALX-152-002-PC05
0.5 mg*
560.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Ile-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
193
H
289
N
49
O
58
S
5
MW:
4384.1
CAS NUMBER:
121014-54-8
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin:
Y. Itoh, et al.; FEBS Lett.
231
, 440 (1988)
Abstract
A novel potent vasoconstrictor peptide produced by vascular endothelial cells [see comments]:
M. Yanagisawa, et al.; Nature
332
, 411 (1988)
Abstract
Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo:
T. Kashiwabara, et al.; FEBS Lett.
247
, 73 (1989)
Abstract
Further Categories Containing This Product:
Peptides
ALX-152-003
Revised 26-Nov-04
Big Endothelin-1 (1-39) (rat)
SYNONYMS
Big ET-1 (1-39) (rat)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-003-PC01
0.1 mg*
110.00 USD
ALX-152-003-PC05
0.5 mg*
390.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Arg-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
192
H
292
N
50
O
58
S
5
MW:
4389.1
CAS NUMBER:
135842-15-8
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA:
T. Sakurai, et al.; BBRC
175
, 44 (1991)
Abstract
Further Categories Containing This Product:
Peptides
ALX-152-014
Revised 13-Jan-05
Big Endothelin-1 (19-37) (human), [Phe22]-
SYNONYMS
[Phe
22
]-Big ET-1 (19-37) (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-014-MC05
0.5 mg
120.00 USD
ALX-152-014-M001
1 mg
190.00 USD
Product Specification
SEQUENCE:
H-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-OH
FORMULA:
C
100
H
152
N
26
O
26
MW:
2134.5
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of endothelin-converting enzyme (ECE).
Further Categories Containing This Product:
Peptides
ALX-152-012
Revised 14-Dec-04
Big Endothelin-1 (22-38) (human)
SYNONYMS
Big ET-1 (22-38) (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-012-MC05
0.5 mg
100.00 USD
ALX-152-012-M001
1 mg
180.00 USD
Product Specification
SEQUENCE:
H-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH
FORMULA:
C
80
H
125
N
23
O
25
MW:
1809.0
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin:
Y. Itoh, et al.; FEBS Lett.
231
, 440 (1988)
Abstract
Further Categories Containing This Product:
Peptides
ALX-152-004
Revised 12-May-03
Big Endothelin-2 (1-37) (human)
SYNONYMS
Big ET-2 (1-37) (human)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-152-004-PC01
0.1 mg*
110.00 USD
ALX-152-004-PC05
0.5 mg*
390.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Gln-Thr-Ala-Pro-Tyr-Gly-Leu-Gly-Asn-Pro-Pro-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
188
H
269
N
45
O
56
S
4
MW:
4183.8
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization
:
S. Ohkubo, et al.; FEBS Lett.
274
, 136 (1990)
Abstract
Further Categories Containing This Product:
Peptides
ALX-850-008
Revised 24-Feb-05
Endothelin EIA Kit
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-850-008-KI01
1 Kit
607.00 USD
Product Specification
SENSITIVITY:
1.5pg/ml.
QUANTITY:
96 wells (~80 tests).
SPECIFICITY:
ET-1=100%, ET-2=100%, ET-3=100%, VIC=100%, Sarafotoxin=100%, Big ET=<0.01%.
APPLICATION:
For the quantitative determination of endothelin (endothelin-1, -2, -3 and VIC) in serum, plasma, urine or cell culture media.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
ELISA & EIA Kits
ALX-201-032
Revised 08-Feb-06
Proendothelin-1 (human) (recombinant)
SYNONYMS
ProET-1 (human) (recombinant)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-032-C004
4 µg
190.00 USD
Product Specification
MW:
~26kDa.
SOURCE/HOST:
Produced in XL1-Blue cells. Human proendothelin-1 (aa 18-212) is fused to a His-tag. The N-terminal peptide sequence Met-Arg-Gly-Ser-(His)
6
replaces the signal peptide.
PURITY:
~80% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains no preservatives.
RECONSTITUTION:
Reconstitute in sterile water.
BIOLOGICAL ACTIVITY:
4µg (160pmoles) of recombinant human proendothelin-1 when cleaved with furin and chymosin has been shown to produce endothelin-1 mediated vasoconstriction of rat vas deferens and rabbit carotid artery.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Processing of proendothelin-1 by human furin convertase:
J.-B. Denault, et al.; FEBS Lett.
362
, 276 (1995)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P25101:
Endothelin-1 (human) (precursor)
AfCS Signalling Gateway link A000062:
Endothelin-1 (mouse)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-155-001
Revised 06-Apr-06
Endothelin-1 (human, mouse, rat, pig, bovine, dog)
SYNONYMS
ET-1 (human, mouse, rat, pig, bovine, dog)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-155-001-PC01
0.1 mg*
72.00 USD
ALX-155-001-PC05
0.5 mg*
265.00 USD
ALX-155-001-P001
1 mg*
435.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
109
H
159
N
25
O
32
S
5
MW:
2492.0
CAS NUMBER:
117399-94-7
MERCK INDEX:
14:
3576
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥98% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in water or 1% sodium hydrogen carbonate. Hardly soluble in acidic solutions.
RECONSTITUTION:
Reconstitute with 10µl distilled water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solution is stable for 1-2 weeks when stored at -20°C. Prepare solution only before use.
HAZARD:
HARMFUL.
Product Specific Literature References
Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin:
Y. Itoh, et al.; FEBS Lett.
231
, 440 (1988)
Abstract
Synthesis and disulfide structure determination of porcine endothelin: an endothelium-derived vasoconstricting peptide:
S. Kumagaye, et al.; Int. J. Pept. Prot. Res.
32
, 519 (1988)
Abstract
A novel potent vasoconstrictor peptide produced by vascular endothelial cells [see comments]:
M. Yanagisawa, et al.; Nature
332
, 411 (1988)
Abstract
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes:
A. Inoue, et al.; PNAS
86
, 2863 (1989)
Abstract
Molecular biology and biochemistry of the endothelins:
M. Yanagisawa & T. Masaki; TIPS
10
, 374 (1989)
Abstract
G.J. Price & L. Malone; Nucl. Acids Res.
18
, 3658 (1990)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-002
Revised 14-Dec-04
Endothelin-2 (human, pig, dog)
SYNONYMS
ET-2 (human, pig, dog)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-155-002-PC01
0.1 mg*
72.00 USD
ALX-155-002-PC05
0.5 mg*
265.00 USD
ALX-155-002-P001
1 mg*
435.00 USD
Product Specification
SEQUENCE:
H-Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH
(Disulfide bonds between Cys
1
-Cys
15
and Cys
3
-Cys
11
)
FORMULA:
C
115
H
160
N
26
O
32
S
4
MW:
2547.0
CAS NUMBER:
123562-20-9
MERCK INDEX:
14:
3576
QUANTITY:
*Sold as net peptide weight.
PURITY:
≥98%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes:
A. Inoue, et al.; PNAS
86
, 2863 (1989)
Abstract
Further Categories Containing This Product:
Peptides
ALX-155-003
Revised 30-Oct-06
Endothelin-3 (human, rat, pig)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-155-003-PC01
0.1 mg*
72.00 USD
ALX-155-003-PC05
0.5 mg*
