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Natural Products / Antibiotics
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ALX-350-288 Revised 21-May-08
Mycalolide B
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-288-C100   100 µg 590.00 USD Add To Cart
Product Specification
FORMULA: C52H74N4O17
MW: 1027.2
CAS NUMBER: 122752-21-0
SOURCE/HOST: Isolated from the marine sponge Mycale sp.
PURITY: ≥98%
APPEARANCE: Clear to white solid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas.
HAZARD: TOXIC.

Product Description
Inhibits actin polymerization (IC50=10-50nM) with a different mechanism of action from cytochalasin D (Prod. No. ALX-380-031). Suppresses actin-activated myosin Mg2+-ATPase activity. Depolymerizes F-actin by nibbling and forms a 1:1 complex with G-actin.
Product Specific Literature References
Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge: M. Hori, et al.; FEBS Lett. 322, 151 (1993) Abstract
Mycalolide B, a novel actin depolymerizing agent: S. Saito, et al.; J. Biol. Chem. 269, 29710 (1994) Abstract; Full Text
Cellular changes of rat embryonic fibroblasts by an actin-polymerization inhibitor, bistheonellide A, from a marine sponge: S. Watabe, et al.; Cell Struct. Funct. 21, 199 (1996) Abstract
Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D: A. Sugidachi, et al.; Thromb. Haemost. 79, 614 (1998) Abstract
Actin-binding specificity of marine macrolide toxins, mycalolide B and kabiramide D: S. Wada, et al.; J. Biochem. (Tokyo) 123, 946 (1998) Abstract; Full Text
Uncoupling of gate and fence functions of MDCK cells by the actin-depolymerizing reagent mycalolide B: R. Takakuwa, et al.; Exp. Cell Res. 257, 238 (2000) Abstract
Actin filaments play an essential role for transport of nascent HIV-1 proteins in host cells: H. Sasaki, et al.; BBRC 316, 588 (2004) Abstract
Further Categories Containing This Product:
Natural Products - ATPase Inhibitors • Actin / Related Products • Marine Natural Products
 
 
ALX-380-015 Revised 08-Oct-07
Mycophenolic acid
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SYNONYMS 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexanoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-015-M050   50 mg 30.00 USD Add To Cart
ALX-380-015-M250   250 mg 105.00 USD Add To Cart
ALX-380-015-G001   1 g 310.00 USD Add To Cart
Product Specification
FORMULA: C17H20O6
MW: 320.3
CAS NUMBER: 24280-93-1
MERCK INDEX: 14: 6327
SOURCE/HOST: Isolated from Penicillium brevi-compactum.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol or methylene chloride; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description

Immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine-5’-monophosphate (IMP). Prevents the formation of xanthosine-5’-monophosphate (XMP) and guanosine-5’-monophosphate (GMP). Depletes tetrahydrobiopterin and decreases nitric oxide (NO) production by iNOS (NOS II) without affecting nNOS (NOS I) activity. Suppresses cytokine-induced nitric oxide (NO) production in mouse and rat vascular endothelial cells.
Product Specific Literature References
Guanine nucleotide depletion and toxicity in mouse T lymphoma (S-49) cells: M.B. Cohen, et al.; J. Biol. Chem. 256, 8713 (1981) Abstract; Full Text
Pharmacodynamic assessment of mycophenolic acid-induced immunosuppression by measuring IMP dehydrogenase activity: L.J. Langman, et al.; Clin. Chem. 41, 295 (1995) Abstract
Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells: M. Senda, et al.; Transplantation 60, 1143 (1995) Abstract
Mycophenolate mofetil and its mechanisms of action: A.C. Allison & E.M. Eugui; Immunopharmacology 47, 85 (2000) Abstract
Mycophenolic acid downregulates inducible nitric oxide synthase induction in astrocytes: D. Miljkovic, et al.; Glia 39, 247 (2002) Abstract
Mycophenolic acid inhibits inosine 5´-monophosphate dehydrogenase and suppresses production of pro-inflammatory cytokines, nitric oxide, and LDH in macrophages: C.A. Jonsson & H. Carlsten; Cell Immunol. 216, 93 (2002) Abstract
Inducible nitric oxide synthase inhibition by mycophenolic acid: D. Miljkovic, et al.; Mini Rev. Med. Chem. 4, 741 (2004), Review Abstract
Antifibrotic actions of mycophenolic acid: C. Morath, et al.; Clin. Transplant. 20, 25 (2006), Review Abstract
Further Categories Containing This Product:
Antibiotics - Nitric Oxide Pathway Modulators • Phenolic Acids
 
 
ALX-385-012 Revised 19-Nov-07
Myricetin
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SYNONYMS 3,3',4',5,5',7-Hexahydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-012-M010   10 mg 35.00 USD Add To Cart
ALX-385-012-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C15H10O8
MW: 318.2
CAS NUMBER: 529-44-2
MERCK INDEX: 14: 6332
RTECS: LK8646000
PURITY: ≥97%
APPEARANCE: Light yellow-green crystals.
SOLUBILITY: Soluble in alcohol; slightly soluble in water (warm); insoluble in acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Antioxidant flavonoid. Has antitumor and chemopreventive properties. Anti-inflammatory. Inhibits NF-κB activation. 
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Biological effects of myricetin: K. C. Ong & H. E. Khoo; Gen. Pharmacol. 29, 121 (1997), (Review) Abstract
In vitro cytotoxicity of glyco-S-nitrosothiols. a novel class of nitric oxide donors: H. Babich & H.L. Zuckerbraun; Toxicol. In Vitro 15, 181 (2001) Abstract
Suppression of TNFalpha-mediated NFkappaB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells: S. H. Tsai, et al.; J. Cell Biochem. 74, 606 (1999) Abstract
Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells: C.H. Ko, et al.; Mol. Cancer Ther. 4, 281 (2005) Abstract
Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascade: C.H. Ko, et al.; Biochem. Pharmacol. 69, 913 (2005) Abstract
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity: J. Lu, et al.; Cancer Res. 66, 4410 (2006) Abstract
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1: K.W. Lee, et al.; Carcinogenesis 28, 1918 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • NF-kB Pathway Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antitumor Reagents • Natural Products - Antioxidants • Natural Products - Anti-inflammatory Agents • Natural Products - NF-kB Pathway Inhibitors
 
 
ALX-350-274 Revised 16-Jun-08
Myriocin
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SYNONYMS ISP-1
Thermozymocidin
2S,3R,4R,6E-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxo-6-eicosenoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Immunomodulators
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ALX-350-274-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C21H39NO6
MW: 401.5
CAS NUMBER: 35891-70-4
RTECS: JX3890000
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (25mg/ml; heat briefly in boiling water bath) or in dilute base (5mg/ml; 50mM NaOH).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Potent immunosuppressant ~10 to 100-fold more potent than cyclosporin A (Prod. No. ALX-380-002). Blocks sphingolipid biosynthesis by inhibiting serine palmitoyltransferase (Ki=0.28nM). Induces apoptosis by depletion of cellular sphingolipids. Inhibits proliferation of an IL-2-dependent mouse cytotoxic cell line CTLL-1 (IC50=15nM).
Product Specific Literature References
Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite: T. Fujita, et al.; J. Antibiot. 47, 208 (1994) Abstract
Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin: Y. Miyake, et al.; BBRC 211, 396 (1995) Abstract
Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells: S. Furuya, et al.; J. Neurochem. 71, 366 (1998) Abstract
Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells: K. Hidari, et al.; J. Biol. Chem. 271, 14636 (1996) Abstract
Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast: Y. Sun, et al.; Mol. Cell. Biol. 20, 4411 (2000) Abstract; Full Text
Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice: M.R. Hojjati, et al.; J. Biol. Chem. 280, 10284 (2005) Abstract
Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model: T. Umehara, et al.; BBRC 346, 67 (2006) Abstract
Related Products
Further Categories Containing This Product:
Sphingolipids & Glycosphingolipids Other Products • Natural Products - Antiviral / anti-HIV Agents • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-227 Revised 28-Apr-08
Myristicin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-227-M100   100 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C11H12O3
MW: 192.2
CAS NUMBER: 607-91-0
MERCK INDEX: 14: 6334
SOURCE/HOST: Isolated from Petroselinium hortense Hoffmann.
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless to slightly yellow liquid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Natural product isolated from parsley oil. Inducer of glutathione S-transferases. Also inhibits chemical carcinogenesis. Induces rat and human cytochrome P450 enzymes. Has very potent hepatoprotective activity. Induces apoptosis.
Product Specific Literature References
Myristicin: a potential cancer chemopreventive agent from parsley leaf oil: G.-Q. Zheng, et al.; J. Agri. Food Chem. 40, 107 (1992)
Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a volatile aroma constituent of parsley leaf oil: G.-Q. Zheng, et al.; Carcinogenesis 13, 1921 (1992) Abstract
Induction of rat hepatic cytochrome P450 enzymes by myristicin: H.G. Jeong & C.H. Yun; BBRC 217, 966 (1995) Abstract
Toxicological evaluation of myristicin: H. Hallstrom & A. Thuvander; Nat. Toxins 5, 186 (1997), Review Abstract
Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin: C.H. Yun, et al.; Toxicol. Lett. 137, 143 (2003) Abstract
Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/ d-galactosamine-induced liver injury: T. Morita, et al.; J. Agric. Food Chem. 51, 1560 (2003) Abstract
Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells: B.K. Lee, et al.; Toxicol. Lett. 157, 49 (2005) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Cytochrome P450 [CYP450] / Related Products • Glutathione S-Transferase • Active Substances from Fruit and Vegetables • Natural Products - Apoptosis Inducers & Inhibitors • Lipopolysaccharides [LPS] / Related Products
 
 
ALX-350-222 Revised 28-Mar-08
Dihydromyristicin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-222-M100   100 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C11H14O3
MW: 194.2
CAS NUMBER: 52811-28-6
PURITY: ≥98% (TLC)
APPEARANCE: Colorless liquid.
SOLUBILITY: Soluble in 100% ethanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Hydrogenated product of myristicin (Prod. No. ALX-350-227), a natural constituent of parsley. Inducer of glutathione S-transferases.
Product Specific Literature References
Myristicin: a potential cancer chemopreventive agent from parsley leaf oil: G.-Q. Zheng, et al.; J. Agri. Food Chem. 40, 107 (1992)
Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a volatile aroma constituent of parsley leaf oil: G.Q. Zheng, et al.; Carcinogenesis 13, 1921 (1992) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Glutathione S-Transferase • Active Substances from Fruit and Vegetables
 
 
ALX-380-294 Revised 15-Apr-08
Nadifloxacin
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SYNONYMS 9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
Jinofloxacin
OPC-7251
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ALX-380-294-M250   250 mg 90.00 USD Add To Cart
ALX-380-294-G001   1 g 270.00 USD Add To Cart
Product Specification
FORMULA: C19H21FN2O4
MW: 360.4
CAS NUMBER: 124858-35-1
MERCK INDEX: 14: 6345
PURITY: ≥98% (Assay)
APPEARANCE: White to yellow crystalline solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Fluoroquinolone with broad spectrum activity against Gram-negative and Gram-positive bacteria. Inhibits the generation of O2- and OH radicals by neutrophils. Inhibits the production of inflammtory cytokines.
Product Specific Literature References
Studies on antibacterial agents. I. Synthesis of substituted 6,7-dihydro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acids: H. Ishikawa, et al.; Chem. Pharm. Bull. 37, 2103 (1989) Abstract
Clinical and bacteriologic evaluation of OPC-7251 in patients with acne: a double-blind group comparison study versus cream base: I. Kurokawa, et al.; J. Am. Acad. Dermatol. 25, 674 (1991) Abstract
Comparative activity of the topical quinolone OPC-7251 against bacteria associated with acne vulgaris: K. Vogt, et al.; Eur. J. Clin. Microbiol. Infect. Dis. 11, 943 (1992) Abstract
Effect of nadifloxacin on neutrophil functions: H. Akamatsu, et al.; J. Int. Med. Res. 23, 19 (1995) Abstract
Relationship between mutations in the DNA gyrase and topoisomerase IV genes and nadifloxacin resistance in clinically isolated quinolone-resistant Staphylococcus aureus: N. Oizumi, et al.; J. Infect. Chemother. 7, 191 (2001) Abstract
Activity of nadifloxacin (OPC-7251) and seven other antimicrobial agents against aerobic and anaerobic Gram-positive bacteria isolated from bacterial skin infections: P. Nenoff, et al.; Chemotherapy 50, 196 (2004) Abstract
Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes: K. Kuwahara, et al.; J. Dermatol. Sci. 38, 47 (2005) Abstract
Nadifloxacin: a quinolone for topical treatment of skin infections and potential for systemic use of its active isomer, WCK 771: M.R. Jacobs & P.C. Appelbaum; Expert Opin. Pharmacother. 7, 1957 (2006) Abstract
Further Categories Containing This Product:
Antibiotics - Topoisomerase Inhibitors • Antibiotics - DNA Replication Inhibitors • Antibiotics for Inflammation Research
 
 
ALX-380-129 Revised 30-Jun-08 New product
Naphthomycin B
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SYNONYMS 2-Demethylnaphthomycin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-129-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C39H44ClNO9
MW: 706.2
CAS NUMBER: 86825-88-9
SOURCE/HOST: Isolated from Streptomyces sp. Gö 40/14
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to brown solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Ansamycin. Displays antibacterial and antifungal activity.
Product Specific Literature References
Isolation and structural elucidation of naphthomycins B and C: W. Keller-Schierlein, et al.; J. Antibiot. 36, 484 (1983) Abstract
Cineromycins, gamma-butyrolactones and ansamycins by analysis of the secondary metabolite pattern created by a single strain of Streptomyces: H.J. Schiewe & A. Zeeck; J. Antibiot. 52, 635 (1999) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-380-096 Revised 08-Apr-08
Nargenicin A1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-096-M001   1 mg 95.00 USD Add To Cart
ALX-380-096-M005   5 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C28H37NO8
MW: 515.6
SOURCE/HOST: Isolated from Nocardia argentinensis.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white powder.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Antibiotic against Gram-positive bacteria, particularly Staphylococcus and Clostridia. Effective against multi-resistant strains (penicilline, tetracycline, clindamycin, novobiocin, kanamycin, chloramphenicol, erythromycin). The power of effect is comparable to erythromycin.
 
 
ALX-385-010 Revised 08-Apr-08
(±)-Naringenin
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SYNONYMS (±)-4',5,7-Trihydroxyflavanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY