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Src Family Kinases / Related Products
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ALX-151-028 Revised 23-Nov-06
Protein Tyrosine Kinase pp60c-src Substrate
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Src Family Kinases / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-028-M001   1 mg 40.00 USD Add To Cart
ALX-151-028-M005   5 mg 130.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Ile-Tyr-Gly-Glu-Phe-NH2
FORMULA: C33H43N5O10
MW: 668.7
PURITY: ≥98%
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein tyrosine kinase pp60c-src.
Product Specific Literature References
Oncogenes and signal transduction [published erratum appears in Cell 1991 May 31;65(5):following 914]: L.C. Cantley, et al.; Cell 64, 281 (1991), (Review) Abstract
Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c-src: S.A. Nair, et al.; J. Med. Chem. 38, 4276 (1995) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-165-004 Revised 07-Feb-05
pp60v-src (137-157)
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SYNONYMS Peptide A
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Src Family Kinases / Related Products
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ALX-165-004-MC01   0.1 mg 40.00 USD Add To Cart
ALX-165-004-M001   1 mg 160.00 USD Add To Cart
Product Specification
SEQUENCE: H-Val-Ala-Pro-Ser-Asp-Ser-Ile-Gln-Ala-Glu-Glu-Trp-Tyr-Phe-Gly-Lys-Ile-Thr-Arg-Arg-Glu-OH
FORMULA: C111H168N30O35
MW: 2482.7
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Inhibitor of Src and EGF receptor tyrosine kinases. The peptide sequence corresponds to residues 137-157 of the noncatalytic domain of the transforming protein of Rous sarcoma virus (pp60v-scr).
Product Specific Literature References
A synthetic peptide corresponding to residues 137 to 157 of p60v-src inhibits tyrosine-specific protein kinases: K. Sato, et al.; BBRC 171, 1152 (1990) Abstract
Evidence for autoinhibitory regulation of the c-src gene product. A possible interaction between the src homology 2 domain and autophosphorylation site: Y. Fukami, et al.; J. Biol. Chem. 268, 1132 (1993) Abstract; Full Text
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Peptides • Tyrosine Kinase Inhibitors
 
 
ALX-165-022 Revised 04-Mar-05
pp60c-src (521-533) (phosphorylated)
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Src Family Kinases / Related Products
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ALX-165-022-MC05   0.5 mg 50.00 USD Add To Cart
ALX-165-022-M001   1 mg 80.00 USD Add To Cart
ALX-165-022-M005   5 mg 320.00 USD Add To Cart
Product Specification
SEQUENCE: H-Thr-Ser-Thr-Glu-Pro-Gln-Tyr(PO3H2)-Gln-Pro-Gly-Glu-Asn-Leu-OH
FORMULA: C62H95N16O28P
MW: 1543.5
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
This peptide is derived from the C-terminal region of the c-Src protooncogene pp60c-src and binds intramolecularly or intermolecularly to the SH2 domain of the same protein.
Product Specific Literature References
Oncogenes and signal transduction [published erratum appears in Cell 1991 May 31;65(5):following 914]: L.C. Cantley, et al.; Cell 64, 281 (1991), (Review) Abstract
Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src: R.R. Roussel, et al.; PNAS 88, 10696 (1991) Abstract
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Peptides • Tyrosine Kinase Inhibitors
 
 
ALX-165-023 Revised 07-Feb-05
pp60v-src Fragment
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Src Family Kinases / Related Products
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ALX-165-023-M001   1 mg 70.00 USD Add To Cart
ALX-165-023-M005   5 mg 280.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Arg-Leu-Ile-Glu-Asp-Asn-Glu-Tyr-Thr-Ala-Arg-Gly-OH
FORMULA: C66H109N23O23
MW: 1592.7
CAS NUMBER: 81493-98-3
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Protein tyrosine kinase substrate. Residues 2-12 in this peptide correspond to the sequence of the reported site of tyrosine phosphorylation (i.e. aa  412-422) in the Rous sarcoma virus (RSV)-encoded transforming protein pp60v-src. In vitro tyrosine phosphorylation of the peptide is stimulated by epidermal growth factor (EGF).
Product Specific Literature References
Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes: L.J. Pike, et al.; PNAS 79, 1443 (1982) Abstract
Characterization of affinity-purified insulin receptor/kinase. Effects of dithiothreitol on receptor/kinase function: L.J. Pike, et al.; J. Biol. Chem. 261, 3782 (1986) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-166-002 Revised 07-Feb-05
R-R-SRC-Peptide
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Src Family Kinases / Related Products
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ALX-166-002-M001   1 mg 80.00 USD Add To Cart
ALX-166-002-M005   5 mg 350.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-Tyr-Ala-Ala-Arg-Gly-OH
FORMULA: C64H106N22O21
MW: 1519.7
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Substrate for protein tyrosine kinases. The peptide sequence corresponds to the tyrosine phosphorylation site in the Rous sarcoma virus (RSV)-encoded transforming protein pp60v-src. In vitro tyrosine phosphorylation of the peptide is stimulated by epidermal growth factor (EGF).
Product Specific Literature References
Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line: J.E. Casnellie, et al.; PNAS 79, 282 (1982) Abstract
Characterization of affinity-purified insulin receptor/kinase. Effects of dithiothreitol on receptor/kinase function: L.J. Pike, et al.; J. Biol. Chem. 261, 3782 (1986) Abstract; Full Text
Further Categories Containing This Product:
Peptides
 
 
ALX-168-004 Revised 02-Apr-03
H-Tyr-Ile-Tyr-Gly-Ser-Phe-Lys-OH
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Src Family Kinases / Related Products
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ALX-168-004-M001   1 mg 90.00 USD Add To Cart
ALX-168-004-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C44H60N8O11
MW: 877.0
PURITY: 97%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Peptide selected from a random combinatorial peptide library. Specific and efficient substrate for the Src-family protein tyrosine kinase than cdc2 (6-20).
Product Specific Literature References
Identification and characterization of a novel synthetic peptide substrate specific for Src-family protein tyrosine kinases: K.S. Lam, et al.; Int. J. Peptide Protein Res. 45, 587 (1995) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-210-564 Revised 29-Nov-04
Polyclonal Antibody to Lck-interacting Molecule (human)
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SYNONYMS anti-LIME (human) PAb
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-210-564-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY: >95% (SDS-PAGE).
FORMULATION: Liquid. In PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant intracellular fragment corresponding to aa 141-295 of human LIME (Lck-interacting molecule).
SPECIFICITY: Recognizes human LIME. Does not cross-react with mouse LIME.
APPLICATION: Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Src Family Kinases / Related Products • Polyclonal Antibodies
 
 
ALX-210-565 Revised 29-Nov-04
Polyclonal Antibody to Lck-interacting Molecule (mouse)
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SYNONYMS anti-LIME (mouse) PAb
PRODUCT LINE Immunology
PRODUCT CATEGORY Adaptor Proteins in T Cell Signal Transduction / Related Products
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ALX-210-565-C100   100 µg 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY: >95% (SDS-PAGE).
FORMULATION: Liquid. Protein A affinity purified antibody in PBS, pH 7.4, containing 15mM sodium azide.
IMMUNOGEN: Recombinant fragment of mouse LIME (Lck-interacting molecule).
SPECIFICITY: Recognizes mouse LIME. Does not cross-react with human LIME.
APPLICATION: Immunoprecipitation
Western Blot
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Src Family Kinases / Related Products • Polyclonal Antibodies
 
 
ALX-210-827 Revised 18-Oct-07
Polyclonal Antibody to Lck (human)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Kinases in T Cell Signal Transduction / Related Products
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ALX-210-827-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Contains 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 38-57 (R38NGSEVRDPLVTYEGSNPPA57) of human Lck.
SPECIFICITY: Recognizes human Lck.
APPLICATION: Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Specific Literature References
The structure of the mu/pseudo light chain complex on human pre-B cells is consistent with a function in signal transduction: G.S. Brouns, et al.; Eur. J Immunol. 23, 1088 (1993) Abstract
Further Categories Containing This Product:
Autoimmunity & Self Tolerance Other Products • Src Family Kinases / Related Products • Polyclonal Antibodies
 
 
ALX-270-177 Revised 17-Apr-07
PP1
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SYNONYMS 4-Amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]-pyrimidine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Tyrosine Kinase Inhibitors
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ALX-270-177-M001   1 mg 70.00 USD Add To Cart
ALX-270-177-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C16H19N5
MW: 281.4
CAS NUMBER: 172889-26-8
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, slightly soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50=5nM and 6nM respectively). Displays >8'000-fold selectivity over ZAP-70 and Jak2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.
Product Specific Literature References
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation: J.H. Hanke, et al.; J. Biol. Chem. 271, 695 (1996) Abstract; Full Text
Signal characteristics of G protein-transactivated EGF receptor: H. Daub, et al.; EMBO J. 16, 7032 (1997) Abstract; Full Text
Src family-selective tyrosine kinase inhibitor, PP1, inhibits both Fc epsilonRI- and Thy-1-mediated activation of rat basophilic leukemia cells: M. Amoui, et al.; Eur. J. Immunol. 27, 1881 (1997) Abstract
The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells: H. Tang, et al.; J. Biol. Chem. 273, 18268 (1998) Abstract; Full Text
Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors: T. Igishi and J.S. Gutkind; BBRC 244, 5 (1998) Abstract
Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase: D.J. Osterhout, et al.; J. Cell Biol. 145, 1209 (1999) Abstract; Full Text
Structural basis for selective inhibition of Src family kinases by PP1: Y. Liu, et al.; Chem. Biol. 6, 671 (1999) Abstract
Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras: J. Abe, et al.; J. Biol. Chem. 275, 1739 (2000) Abstract; Full Text
Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells: J. Geginat, et al.; J. Exp. Med. 194, 1711 (2001) Abstract; Full Text
The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes: F. Carlomagno, et al.; Cancer Res. 62, 1077 (2002) Abstract; Full Text
The specificities of protein kinase inhibitors: an update: J. Bain, et al.; Biochem. J. 371, 199 (2003) Abstract; Full Text
The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases: L. Tatton, et al.; J. Biol. Chem. 278, 4847 (2003) Abstract; Full Text
Further Categories Containing This Product:
Src Family Kinases / Related Products • Kinases in T Cell Signal Transduction / Related Products
 
 
ALX-270-181 Revised 28-Jul-08
Damnacanthal
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SYNONYMS 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
PRODUCT LINE Immunology
PRODUCT CATEGORY Kinases in T Cell Signal Transduction / Related Products
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ALX-270-181-M001   1 mg 165.00 USD Add To Cart
Product Specification
FORMULA: C16H10O5
MW: 282.3
CAS NUMBER: 477-84-9
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow to orange solid.
SOLUBILITY: 10mg/ml soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Potent and selective inhibitor of p56lck tyrosine kinase activity. Inhibition of p56lck by damnacanthal appears to be reversible, not time-dependent and not significantly affected by the presence of sulfhydryl reagents.
Product Specific Literature References
S. Nonomura; J. Pharm. Soc. Jpn. 75, 219 (1955)
N.R. Ayyangar, et al.; Tetrahedron 6, 331 (1959)
Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum: K.Koumaglo, et al.; Planta Medica 58, 533 (1992) Abstract
Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia: T. Hiramatsu, et al.; Cancer Lett. 73, 161 (1993) Abstract
Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity: C.R. Faltynek, et al.; Biochemistry 34, 12404 (1995) Abstract