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Glutamate Receptors (Metabotropic) / Related Products
You are here: Product Lines > Signal Transduction > Glutamate Receptors (Metabotropic) / Related Products
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ALX-106-023 Revised 13-Dec-02
5-Hydroxy-L-tryptophan
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-106-023-M500   500 mg 20.00 USD Add To Cart
Product Specification
FORMULA: C11H12N2O3
MW: 220.2
CAS NUMBER: 56-69-9
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Serotonin precursor.
Further Categories Containing This Product:
Special Amino Acids • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-106-024 Revised 14-Oct-08
O-Phospho-L-serine
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SYNONYMS L-Phosphoserine
L-Serine-O-phosphate
PRODUCT LINE Neurobiology
PRODUCT CATEGORY NMDA Receptors / Related Products
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ALX-106-024-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C3H8NO6P
MW: 185.1
CAS NUMBER: 407-41-0
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Store tightly sealed. Use fresh solutions.

Product Description
L-AP4 agonist. Competitive NMDA antagonist. Has affinity for type IV, but not type I, metabotropic glutamate receptor.
Product Specific Literature References
L-phosphoserine, a metabolite elevated in Alzheimer's disease, interacts with specific L-glutamate receptor subtypes: W.E. Klunk, et al.; J. Neurochem. 56, 1997 (1991) Abstract
Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor: C. Thomsen & P.D. Suzdak; Neuroreport 4, 1099 (1993) Abstract
Agonists and antagonists for metabotropic glutamate receptors: P.L. Ornstein, et al.; Curr. Pharm. Design 1, 355 (1995), (Review)
Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis: K. Borodezt & S.R. D'Mello; J. Neurosci. Res. 53, 531 (1998) Abstract
Further Categories Containing This Product:
Special Amino Acids • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-151-020 Revised 10-Feb-05
N-Acetyl-Asp-Glu-OH
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SYNONYMS α-NAAG
Spaglumic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-151-020-M010   10 mg 35.00 USD Add To Cart
ALX-151-020-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C11H16N2O8
MW: 304.3
CAS NUMBER: 3106-85-2
PURITY: ≥98%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Endogenous neurotransmitter with high affinity for the brain glutamate receptor. N-acetylated α-linked acidic dipeptidase (NAALADase), a membrane-bound peptidase, hydrolyzes α-NAAG, a major brain peptide, to N-acetylaspartate and glutamate. Discriminates between mGluR2 and mGluR3. mGluR3 activator. NMDA receptor antagonist. Neuroprotective.
Product Specific Literature References
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain glutamate receptor: R. Zaczek, et al.; PNAS 80, 1116 (1983) Abstract
Characterization of the interactions of N-acetyl-aspartyl-glutamate with [3H]L-glutamate receptors: K.J. Koller & J.T. Coyle; Eur. J. Pharmacol. 98, 193 (1984) Abstract
The neurobiology of N-acetylaspartylglutamate: R.D. Blakely & J.T. Coyle; Int. Rev. Neurobiol. 30, 39 (1988) Abstract
Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase: P.F. Jackson, et al.; J. Med. Chem. 39, 619 (1996) Abstract
The nagging question of the function of N-acetylaspartylglutamate: J.T. Coyle; Neurobiol. Dis. 4, 231 (1997) Abstract
N-acetylaspartylglutamate stimulates metabotropic glutamate receptor 3 to regulate expression of the GABA(A) alpha6 subunit in cerebellar granule cells: S. Ghose, et al.; J. Neurochem. 69, 2326 (1997) Abstract
N-acetylaspartylglutamate (NAAG) protects against rat striatal quinolinic acid lesions in vivo: L.R. Orlando, et al.; Neurosci. Lett. 236, 91 (1997) Abstract
N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases: L.A. Passani, et al.; Mol. Chem. Neuropathol. 31, 97 (1997) Abstract
Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease: L.A. Passani, et al.; Brain Res. 772, 9 (1997) Abstract
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells: B. Wroblewska, et al.; J. Neurochem. 69, 174 (1997) Abstract
Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells: V. Bruno, et al.; Neuroscience 85, 751 (1998) Abstract
N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes: B. Wroblewska, et al.; Glia 24, 172 (1998) Abstract
A.P. Burlina, et al.; Eur. J. Pediatr. 158, 406 (1999) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • NAALADase / Related Products • Peptides
 
 
ALX-550-005 Revised 16-Feb-05
trans-1,2-homo-ACPD
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SYNONYMS (±)-trans-1-Amino-1-carboxycyclopentane-2-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-005-M005   5 mg 48.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Selective antagonist for group II mGluRs.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-006 Revised 16-Feb-05
trans-1,3-homo-ACPD
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SYNONYMS (±)-trans-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-006-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.


(1R,3S)-homo-ACPD
Product Description
Equimolar mixture of (1R,3S)-homo-ACPD (Prod. No. ALX-550-008) and (1S,3R)-homo-ACPD (Prod. No. ALX-550-007). Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-007 Revised 26-Apr-07
(1S,3R)-homo-ACPD
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SYNONYMS (1S,3R)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-007-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Active isomer of trans-1,2-homo-ACPD (Prod. No. ALX-550-006). Highly selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-008 Revised 24-Feb-05
(1R,3S)-homo-ACPD
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SYNONYMS (1R,3S)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-008-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in diluted sodium hydroxide solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

(1R,3S)-homo-ACPD
Product Description
Inactive isomer of trans-1,3-homo-ACPD (Prod. No. ALX-550-006).
Product Specific Literature References
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-009 Revised 24-Nov-04
cis-1,3-homo-ACPD
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SYNONYMS (±)-cis-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-009-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
Product Description
Equimolar mixture of (1R,3R)-homo-ACPD (Prod. No. ALX-550-010) and (1S,3S)-homo-ACPD (Prod. No. ALX-550-011). Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-010 Revised 16-Feb-05
(1R,3R)-homo-ACPD
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SYNONYMS (1R,3R)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-010-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Active isomer of cis-1,3-homo-ACPD (Prod. No. ALX-550-009) Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-011 Revised 24-Nov-04
(1S,3S)-homo-ACPD
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SYNONYMS (1S,3S)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-011-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Isomer of cis-1,3-homo-ACPD (Prod. No. ALX-550-009). Partial agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-017 Revised 17-Jan-05
cis-ACPD
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SYNONYMS (±)-1-Aminocyclopentane-cis-1,3-dicarboxylic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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ALX-550-017-M005   5 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C7H11NO4
MW: 173.2
CAS NUMBER: 39026-63-6
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

(1S,3S)-ACPD
(1R,3R)-ACPD
Product Description
Potent NMDA agonist. Equimolar mixture of (1R,3R)-ACPD (Prod. No. ALX-550-018) and (1S,3S)-ACPD (Prod. No. ALX-550-019).
Product Specific Literature References
Receptors for the excitatory amino acids in the mammalian central nervous system: H. McLennan; Prog. Neurobiol. 20, 251 (1983) Abstract
Structure/activity relations of N-methyl-D-aspartate receptor ligands as studied by their inhibition of [3H]D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes: H.J. Olverman, et al.; Neuroscience 26, 17 (1988) Abstract
In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects: D.D. Schoepp, et al.; J. Neurochem. 56, 1789 (1991) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products • Excitatory Amino Acids