• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
AMPA Receptors / Related Products
You are here: Product Lines > Neurobiology > Excitatory Amino Acids & Receptors > Glutamate Receptors (Ionotropic) / Related Products > AMPA Receptors / Related Products
Toolbar - View Selection
 
Items 15 of 15
ALX-550-016 Revised 08-Nov-07
(S)-AMPA
Add to Clipboard
SYNONYMS (S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-016-M005   5 mg 95.00 USD Add To Cart
ALX-550-016-M025   25 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C7H10N2O4
MW: 186.2
CAS NUMBER: 83643-88-3
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Hygroscopic.

Product Description
Active enantiomer of (R,S)-AMPA (Prod. No. ALX-550-023).
Product Specific Literature References
Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid: J.J. Hansen, et al.; J. Med. Chem. 26, 901 (1983) Abstract
Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors: J. Lauridsen, et al.; J. Med. Chem. 28, 668 (1985) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Special Amino Acids
 
 
ALX-550-023 Revised 04-Apr-08
(R,S)-AMPA
Add to Clipboard
SYNONYMS (R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-023-M005   5 mg 65.00 USD Add To Cart
ALX-550-023-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C7H10N2O4
MW: 186.2
CAS NUMBER: 74341-63-2
PURITY: ≥97% (HPLC)
APPEARANCE: White powder.
SOLUBILITY: Soluble in water (10mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Potent and selective quisqualate analog that interacts with the AMPA subgroup of ionotropic glutamate receptors.
Product Specific Literature References
New class of glutamate agonist structurally related to ibotenic acid: P. Krogsgaard-Larsen, et al.; Nature 284, 64 (1980) Abstract
The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes: T. Honoré, et al.; J. Neurochem. 38, 173 (1982) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
 
 
ALX-550-360 Revised 19-Aug-02
α-Benzylquisqualic acid
Add to Clipboard
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-360-M001   1 mg 30.00 USD Add To Cart
ALX-550-360-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C12H13N3O5
MW: 279.3
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selective antagonist of group II mGluRs.
Product Specific Literature References
alpha-substituted quisqualic acid analogs: new metabotropic glutamate receptor group II selective antagonists: A.P. Kozikowski, et al.; Bioorg. Med. Chem. Lett. 8, 447 (1998) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products
 
 
ALX-550-155 Revised 28-Jan-05
(RS)-4-Bromo-homo-ibotenic acid
Add to Clipboard
SYNONYMS Br-HIBO
(RS)-α-Amino-4-bromo-3-hydroxy-5-isoazolepropionic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-155-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C6H7N2O4Br
MW: 251.0
CAS NUMBER: 71366-32-0
PURITY: ≥98%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Potent AMPA receptor agonist. Selective but relatively non-potent group I mGluR agonist.
Product Specific Literature References
Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid: J.J. Hansen, et al.; J. Med. Chem. 32, 2254 (1989) Abstract
Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists: J.C. Watkins, et al.; TIPS 11, 25 (1990) Abstract
4-Bromohomoibotenic acid selectively activates a 1-aminocyclopentane- 1S,3R-dicarboxylic acid-insensitive metabotropic glutamate receptor coupled to phosphoinositide hydrolysis in rat cortical slices: D.S. Chung, et al.; J. Neurochem. 63, 133 (1994) Abstract
Effects of bromohomoibotenate on metabotropic glutamate receptors: C. Thomsen, et al.; Neuroreport 5, 2417 (1994) Abstract
4-Methylhomoibotenic acid activates a novel metabotropic glutamate receptor coupled to phosphoinositide hydrolysis: D.S. Chung, et al.; J. Pharmacol. Exp. Ther. 283, 742 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products
 
 
ALX-550-042 Revised 04-Jun-08
CNQX
Add to Clipboard
SYNONYMS 6-Cyano-7-nitroquinoxaline-2,3-dione
FG-9065
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-042-M005   5 mg 43.00 USD Add To Cart
ALX-550-042-M010   10 mg 70.00 USD Add To Cart
ALX-550-042-M025   25 mg 155.00 USD Add To Cart
ALX-550-042-M050   50 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C9H4N4O4
MW: 232.2
CAS NUMBER: 115066-14-3
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in DMSO (10mg/ml) or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions are stable for several months when stored at -20°C.
HANDLING: Protect from light.

Product Description
Potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. For the more soluble form see CNQX . disodium salt (Prod. No. ALX-550-283).
Product Specific Literature References
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science, 241, 701 (1988) Abstract
Differential effects of the excitatory amino acid antagonists, 6-cyano- 7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4- yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice: L. Turski, et al.; Neurosci. Lett. 113, 66 (1990) Abstract
Related Products
Further Categories Containing This Product:
Kainate Receptors / Related Products • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-550-283 Revised 11-Jan-05
CNQX . disodium salt
Add to Clipboard
SYNONYMS 6-Cyano-7-nitroquinoxaline-2,3-dione . 2Na
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-283-M005   5 mg 55.00 USD Add To Cart
ALX-550-283-M010   10 mg 100.00 USD Add To Cart
ALX-550-283-M025   25 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C9H2N4O4 . 2Na
MW: 230.2 . 46.0
PURITY: 98%
APPEARANCE: Dark purple solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Water soluble, potent competitive kainate/quisqualate (non-NMDA) receptor antagonist. More soluble form of CNQX (Prod. No. ALX-550-042).
Product Specific Literature References
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science 241, 701 (1988) Abstract
Differential effects of the excitatory amino acid antagonists, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice: L. Turski, et al.; Neurosci. Lett. 113, 66 (1990) Abstract
Related Products
Further Categories Containing This Product:
Kainate Receptors / Related Products • Glutamate Receptors (Metabotropic) / Related Products
 
 
ALX-550-338 Revised 31-May-07
Cyclothiazide
Add to Clipboard
SYNONYMS 3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3,4-dihydro-3[2-norbornen-5-yl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-338-M010   10 mg 40.00 USD Add To Cart
ALX-550-338-M050   50 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C14H16ClN3O4S2
MW: 389.9
CAS NUMBER: 2259-96-3
MERCK INDEX: 14: 2754
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, methanol (36mg/ml) or dilute aqueous base (36mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
MELTINGPOINT: 228-230°C

Product Description
Potently inhibits the desensitization of AMPA receptors. Antihypertensive.
Product Specific Literature References
Desensitization of AMPA receptors upon multiquantal neurotransmitter release: L.O. Trussell, et al.; Neuron 10, 1185 (1993) Abstract
Differential modulation by cyclothiazide and concanavalin A of desensitization at native alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- and kainate-preferring glutamate receptors: L.A. Wong & M.L. Mayer; Mol. Pharmacol. 44, 504 (1993) Abstract
Cyclothiazide potentiates agonist responses at human AMPA/kainate receptors expressed in oocytes: R.L. Sharp, et al.; Eur. J. Pharmacol. 266, R1 (1994) Abstract
Modulation of AMPA/kainate receptors by cyclothiazide increases cytoplasmic free Ca2+ and 45Ca2+ uptake in brain neurons: G. Cebers & S. Liljequist; Eur. J. Pharmacol. 290, 105 (1995) Abstract
Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists: M.A. Desai, et al.; J. Pharmacol. Exp. Ther. 272, 38 (1995) Abstract
Inhibition by cyclothiazide of neuronal nicotinic responses in bovine chromaffin cells: J.M. Nooney & A. Feltz; Br. J. Pharmacol. 114, 648 (1995) Abstract
 
 
ALX-550-260 Revised 29-Apr-08
Diazoxide
Add to Clipboard
SYNONYMS 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Activators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-260-M500   500 mg 47.00 USD Add To Cart
ALX-550-260-G001   1 g 75.00 USD Add To Cart
Product Specification
FORMULA: C8H7ClN2O2S
MW: 230.7
CAS NUMBER: 364-98-7
MERCK INDEX: 14: 3004
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (25mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL.

Product Description
ATP-sensitive K+ channel activator. Blocks desensitization of AMPA receptors. Acts in pancreatic β-cells, where it is more potent than pinacidil (Prod. No. ALX-550-285). Antihypertensive and vasodilatory agent.
Product Specific Literature References
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells: G. Trube, et al.; Pflugers Arch. Eur. J. Physiol. 407, 493 (1986) Abstract
Protein phosphorylation is required for diazoxide to open ATP-sensitive potassium channels in insulin (RINm5F) secreting cells: M.J. Dunne; FEBS Lett. 250, 262 (1989) Abstract
In vitro and in vivo comparison of two K+ channel openers, diazoxide and cromakalim, and their inhibition by glibenclamide: U. Quast & N.S. Cook; J. Pharmacol. Exp. Ther. 250, 261 (1989) Abstract
The action of diazoxide and minoxidil sulphate on rat blood vessels: a comparison with cromakalim: D.T. Newgreen, et al.; Br. J. Pharmacol. 100, 605 (1990) Abstract
Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells: M.J. Dunne, et al.; J. Membr. Biol. 114, 53 (1990) Abstract
Diazoxide-sensitivity of the adenosine 5'-triphosphate-dependent K+ channel in mouse pancreatic beta-cells: C. Schwanstecher, et al.; Br. J. Pharmacol. 107, 87 (1992) Abstract
Further Categories Containing This Product:
AMPA Receptors / Related Products
 
 
ALX-550-045 Revised 29-Jan-07
DNQX
Add to Clipboard
SYNONYMS 6,7-Dinitroquinoxaline-2,3-dione
FG-9041
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-045-M005   5 mg 16.00 USD Add To Cart
ALX-550-045-M025   25 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C8H4N4O6
MW: 252.1
CAS NUMBER: 2379-57-9
PURITY: ≥98%
APPEARANCE: Off-white to yellow crystalline solid.
SOLUBILITY: Soluble in DMSO, acetone or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C.

Product Description
Potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist.
Product Specific Literature References
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science 241, 701 (1988) Abstract
Contributions of quisqualate and NMDA receptors to the induction and expression of LTP: D. Müller, et al.; Science 242, 1694 (1988) Abstract
Excitatory amino acid receptors in the vertebrate central nervous system: G.L. Collingridge & R.A. Lester; Pharmacol. Rev. 41, 143 (1989), (Review) Abstract
Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors: N.W. Kleckner & R. Dingledine; Mol. Pharmacol. 36, 430 (1989) Abstract
Abolition of the NMDA-mediated responses by a specific glycine antagonist, 6,7-dichloroquinoxaline-2,3-dione (DCQX): Y. Yoneda & K. Ogita; BBRC 164, 841 (1989) Abstract
6,7-Dichloroquinoxaline-2,3-dione is a competitive antagonist specific to strychnine-insensitive [3H]glycine binding sites on the N-methyl-D- aspartate receptor complex: K. Ogita & Y. Yoneda; J. Neurochem. 54, 699 (1990) Abstract
Noncompetitive excitatory amino acid receptor antagonists: D. Lodge & K.M. Johnson; TIPS 11, 81 (1990), (Review) Abstract
Disulfide bonding and cysteine accessibility in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluRD. Implications for redox modulation of glutamate receptors: R. Abele, et al.; J. Biol. Chem. 273, 25132 (1998) Abstract; Full Text
Stereochemistry of quinoxaline antagonist binding to a glutamate receptor investigated by Fourier transform infrared spectroscopy: D.R. Madden, et al.; J. Biol. Chem. 276, 37821 (2001) Abstract; Full Text
Further Categories Containing This Product:
Kainate Receptors / Related Products
 
 
ALX-550-062 Revised 11-Jan-07
IDRA 21
Add to Clipboard
SYNONYMS 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY AMPA Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-062-M005   5 mg 60.00 USD