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Cell Death / Apoptosis / Autophagy
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ALX-270-476 Revised 11-Mar-08
Bicalutamide
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SYNONYMS N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methylpropanamide
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Androgens & Androgen Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-476-M100   100 mg 40.00 USD Add To Cart
ALX-270-476-M500   500 mg 140.00 USD Add To Cart
ALX-270-476-G001   1 g 220.00 USD Add To Cart
Product Specification
FORMULA: C18H14F4N2O4S
MW: 430.4
CAS NUMBER: 90357-06-5
SOURCE/HOST: Synthetic.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in acetone and tetrahydrofuran; slightly soluble in 100% ethanol or methanol; practically insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Nonsteroidal antiandrogen. Effective in the treatment of prostate cancer. Induces cell death by a pathway that is independent of changes in mitochondrial membrane potential and Bcl-2 action.
Product Specific Literature References
Antiproliferative activity of casodex (ICI 176.334) in hormone-dependent tumours: A. Maucher & E. von Angerer; J. Cancer Res. Clin. Oncol. 119, 669 (1993) Abstract
Antiandrogen-induced cell death in LNCaP human prostate cancer cells: E.C. Lee, et al.; Cell Death Differ. 10, 761 (2003) Abstract
Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF kappa B: P.K. Vayalil, et al.; Carcinogenesis 25, 987 (2004) Abstract; Full Text
Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells: M. Verras, et al.; Cancer Res. 64, 8860 (2004) Abstract; Full Text
Glycogen synthase kinase-3beta activity is required for androgen-stimulated gene expression in prostate cancer: X. Liao, et al.; Endocrinology 145, 2941 (2004) Abstract; Full Text
A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2’-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer: K.N. Chi, et al.; J. Natl. Cancer Inst. 97, 1287 (2005) Abstract; Full Text
The mechanisms and managements of hormone-therapy resistance in breast and prostate cancers: K.M. Rau, et al.; Endocr. Relat. Cancer 12, 511 (2005), Review Abstract; Full Text
Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation: P.M. Ghosh, et al.; Endocr. Relat. Cancer 12, 119 (2005) Abstract; Full Text
Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies: M. Mimeault & S.K. Batra; Carcinogenesis 27, 1 (2006), Review Abstract; Full Text
Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak: C. Castilla, et al.; Endocrinology 147, 4960 (2006) Abstract; Full Text
Androgen receptor corepressors and prostate cancer: C.J. Burd, et al.; Endocr. Relat. Cancer 13, 979 (2006), Review Abstract; Full Text
Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells: S. Srinivasan, et al.; Cancer Res. 67, 246 (2006) Abstract; Full Text
Androgen receptor structural and functional elements: role and regulation in prostate cancer: S.M. Dehm & D.J. Tindall; Mol. Endocrinol. 21, 2855 (2007), Review Abstract
Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains: B. Cinar, et al.; JBC 282, 29584 (2007) Abstract; Full Text
A novel class of pyranocoumarin anti-androgen receptor signaling compounds: J. Guo, et al.; Mol. Cancer Ther. 6, 907 (2007) Abstract; Full Text
Increased resistance to trail-induced apoptosis in prostate cancer cells selected in the presence of bicalutamide: M. Mitterberger, et al.; Prostate 67, 1194 (2007) Abstract
Interplay of nuclear factor-kappaB and B-myb in the negative regulation of androgen receptor expression by tumor necrosis factor alpha: S. Ko, et al.; Mol. Endocrinol. 22, 273 (2008) Abstract
Further Categories Containing This Product:
Antitumor Agents (Hormone-related) • Antitumor Agents (Apoptosis Inducers)
 
 
ALX-201-111 Revised 03-Mar-05
tBid (human) (recombinant)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bid / Related Products
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ALX-201-111-C020   20 µg 230.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Truncated C-terminal human Bid (aa 61-195) is fused at the N-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥95% (SDS-PAGE). Affinity purified
FORMULATION: Liquid. In PBS.
BIOLOGICAL ACTIVITY: Facilitates Bax oligomerization and induces cytochrome c release in isolated mitochondria (~10-50ng/ml).
APPLICATION: Studies of Bid/Bax interaction and in vitro cytochrome c release.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
General Information
Bid is an abundant pro-apoptotic protein of the Bcl-2 family that is crucial for death receptor-mediated apoptosis in many cell systems. Bid action has been proposed to involve the mitochondrial re-location of its truncated from tBid, to facilitate the release of apoptogenic proteins like cytochrome c.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P55957: Bid (human)
AfCS Signalling Gateway link A002558: Bid (mouse)
General Literature References
Bid, a critical mediator for apoptosis induced by the activation of Fas/TNF-R1 death receptors in hepatocytes: X.M. Yin; J. Mol. Med. 78, 203 (2000) Abstract
The roles of Bid: M.D. Esposti; Apoptosis 7, 433 (2002) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-152-027 Revised 14-Jul-08
BimL (147-164) (human) (cell permeable)
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SYNONYMS BCL2L11 (147-164) (human) (cell permeable)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bim / Related Products
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ALX-152-027-1   1 Vial 230.00 USD Add To Cart
Product Specification
SEQUENCE: GRKKRRQRRR-GG-WIAQELRRIGDEFNAYYA-amide
FORMULA: C161H261N61O41
MW: 3707.2
QUANTITY: 50µl
CONCENTRATION: 10mM
PURITY: ≥95% (HPLC)
FORMULATION: Liquid. In sterile PBS.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. Keep on ice at all times.
POSITIVE CONTROL: Prod. No. ALX-168-009/1
Product Description
For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.
Related Products
Further Categories Containing This Product:
Peptides
 
 
ALX-260-034 Revised 10-Feb-05
Biotinyl-DEVD-CHO
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SYNONYMS Caspase-3 Inhibitor (Aldehyde)
Caspase-7 Inhibitor (Aldehyde)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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ALX-260-034-M001   1 mg 82.00 USD Add To Cart
ALX-260-034-M005   5 mg 323.00 USD Add To Cart
Product Specification
SEQUENCE: Biotinyl-Asp-Glu-Val-Asp-CHO
FORMULA: C28H42N6O12S
MW: 686.7
PEPTIDE CONTENT: 65-90%.
PURITY: ≥99% (HPLC)
APPEARANCE: White powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in 50% acetic acid with agitation (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Packaged under inert gas.
Product Description
Reversible inhibitor of caspase-3 and -7. Useful for the purification or extract depletion of caspase-3 in conjunction with streptavidin conjugates.
Product Specific Literature References
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995) Abstract
 
 
ALX-260-098 Revised 20-Aug-08
Biotinyl-VAD(OMe)-FMK
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SYNONYMS Caspase Family Inhibitor (Fluoromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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ALX-260-098-M001   1 mg 420.00 USD Add To Cart
Product Specification
SEQUENCE: Biotinyl-Ahx-Val-Ala-Asp(OMe)-fluoromethylketone
FORMULA: C30H49FN6O8S
MW: 672.8
PURITY: ≥90% (TLC)
APPEARANCE: Off-white to brown powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions should be divided into aliquots and stored at -20°C. The stock solution is stable at -20°C for 6-8 months.
HANDLING: Keep cool and dry.
Product Description
Irreversible, cell permeable broad-spectrum caspase inhibitor.
Product Specific Literature References
Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes: J. Li, et al.; J. Biol. Chem. 274, 17325 (1999) Abstract; Full Text
 
 
ALX-260-019 Revised 23-Jun-06
Biotinyl-YVAD-CMK
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SYNONYMS Caspase-1 Inhibitor (Chloromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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ALX-260-019-M001   1 mg 120.00 USD Add To Cart
ALX-260-019-M005   5 mg 480.00 USD Add To Cart
Product Specification
SEQUENCE: Biotinyl-Tyr-Val-Ala-Asp-chloromethylketone
FORMULA: C32H45N6O9SCl
MW: 725.3
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in trifluoroacetic acid (50%).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions should be divided into aliquots and stored at -20°C.
Product Description
Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4.
Product Specific Literature References
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik, et al.; Nature 371, 346 (1994) Abstract
 
 
ALX-201-219 Revised 22-Mar-07
BiP (mouse) (recombinant)
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SYNONYMS GRP78 (mouse) (recombinant)
Glucose Regulated Protein 78 (mouse) (recombinant)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY HSP70 / DnaK / Related Products
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ALX-201-219-C025   25 µg 170.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
PURITY: ≥99% (SDS-PAGE; MS)
FORMULATION: Liquid. In 50mM HEPES, pH 7.5, containing 150mM KCl and 10mM MgCl2.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Specific Literature References
Influence of the oxidoreductase ER57 on the folding of an antibody fab fragment: M. Mayer, et al.; J. Mol. Biol. 341, 1077 (2004) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Endoplasmatic Reticulum Stress
 
 
ALX-620-051 Revised 30-Jun-08
Bisbenzimide H33258 . trihydrochloride
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SYNONYMS HOE 33258
2'-4-(Hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole . 3HCl
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-620-051-M010   10 mg 22.00 USD Add To Cart
ALX-620-051-M050   50 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C25H24N6O . 3HCl
MW: 424.4 . 109.4
CAS NUMBER: 23491-45-4
RTECS: SM1140500
PURITY: ≥98% (TLC)
APPEARANCE: Yellow to greenish powder.
SOLUBILITY: Soluble in water (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: MAY BE MUTAGENIC. HARMFUL.
IDENTITY: Identity determined by IR and 1H-NMR.

Product Description
Cell permeable fluorescent dye with low cytotoxicity. Useful for staining DNA, chromosomes and nuclei [1,2]. Can be used with chromomycin A3 (Prod. No. ALX-380-055) to distinguish chromosomes by their total DNA concentration and their DNA base composition [3,4]. Binds to A:T pairs in DNA. Also useful for controlling gene expression through binding to RNA aptamers inserted into 5' untranslated region of a messenger RNA [5]. Increases the rate of channel-mediated Ca2+ efflux from junctional cytoplasmic reticulum vesicles [6]. Ex(max): 346nm; Em(max): 460nm.
Product Specific Literature References
[1] Spectral studies on 33258 Hoechst and related bisbenzimidazole dyes useful for fluorescent detection of deoxyribonucleic acid synthesis: S.A. Latt & G. Stetten; J. Histochem. Cytochem. 24, 24 (1976) Abstract
[2] Comparison of cellular and nuclear flow cytometric techniques for discriminating apoptotic subpopulations: K.H. Elstein & R.M. Zucker; Exp. Cell. Res. 211, 322 (1994) Abstract
[3] Bacterial characterization by flow cytometry: M.A. Van Dilla, et al.; Science 220, 620 (1983) Abstract
[4] Determination of guanine-plus-cytosine content of bacterial DNA by dual-laser flow cytometry: C.A. Sanders, et al.; J. Gen. Microbiol. 136, 359 (1990) Abstract
[5] Controlling gene expression in living cells through small molecule-RNA interactions: G. Werstuck & M.R. Green; Science 282, 296 (1998) Abstract
[6] Activation and inhibition of the sarcoplasmic reticulum Ca2+ channel by the polycationic dyes Hoechst 33342 and Hoechst 33258: T.J. Beeler & K. Gable; J. Membr. Biol. 135, 109 (1993) Abstract
Related Products
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • MDR Other Products
 
 
ALX-620-050 Revised 02-Sep-05
Bisbenzimide H33342 . trihydrochloride
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SYNONYMS HOE 33342
2'-(4-Ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole . 3HCl
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-620-050-M010   10 mg 22.00 USD Add To Cart
ALX-620-050-M050   50 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C27H28N6O . 3HCl
MW: 452.6 . 109.4
CAS NUMBER: 23491-52-3
PURITY: ≥95%
APPEARANCE: Yellow to green powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC. MAY BE CARCINOGENIC.

Product Description
Cell permeable fluorescent dye that binds to A:T pairs in DNA [1]. Useful for the simultaneous study of the cell cycle and apoptosis in unfixed cells [2]. Also useful for controlling gene expression through binding to RNA aptamers inserted into 5' untranslated region of a messenger RNA [3]. Induces cell differentiation. About 10 times more cell permeable than bisbenzimide H33258 (Prod. No. ALX-620-051). Ex(max): 346nm; Em(max): 460nm.
Product Specific Literature References
[1] Spectral studies on 33258 Hoechst and related bisbenzimidazole dyes useful for fluorescent detection of deoxyribonucleic acid synthesis: S.A. Latt & G. Stetten; J. Histochem. Cytochem. 24, 24 (1976) Abstract
[2] A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells: F. Belloc, et al.; Cytometry 17, 59 (1994) Abstract
[3] Controlling gene expression in living cells through small molecule-RNA interactions: G. Werstuck & M.R. Green; Science 282, 296 (1998) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • MDR Other Products
 
 
ALX-630-107 Revised 21-Feb-08
Bleomycin . sulfate
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SYNONYMS Blenoxane
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-630-107-M010   10 mg 155.00 USD Add To Cart
ALX-630-107-M050