ALEXIS Biochemicals: Agelasine D

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ALX-270-109

Revised 14-Apr-08

Ophiobolin A
SYNONYMS	Cochliobolin A Ophiobalin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-109-MC01		0.1 mg	50.00 USD
ALX-270-109-M001		1 mg	220.00 USD

Product Specification

FORMULA:	C₂₅H₃₆O₄
MW:	400.6
CAS NUMBER:	4611-05-6
RTECS:	RL1576000
SOURCE/HOST:	Isolated from Bipolaris leersia MST-FP107.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL.

Product Description

Cell permeable antagonist of calmodulin. Inhibits Ca²⁺/calmodulin-dependent phosphodiesterase. Inhibits P-glycoprotein-mediated transport. Exhibits antibacterial, antitumor and nematocidal activities. Phytotoxic.

Product Specific Literature References

The structure of ophiobolin, a C25 terpenoid having a novel skeleton: S. Nozoe, et al.; JACS 87, 4968 (1965) Abstract
The constitution of cochliobolin: L. Canonica, et al.; THL 7, 1211 (1966)
Ophiobolin A. A natural product inhibitor of calmodulin: P.C. Leung, et al.; J. Biol. Chem. 259, 2742 (1984) Abstract; Full Text
Role of Calmodulin Inhibition in the Mode of Action of Ophiobolin A: P.C. Leung, et al.; Plant Physiol. 77, 303 (1985) Abstract; Full Text
Characterization of the interaction of ophiobolin A and calmodulin: P.C. Leung, et al.; Int. J. Biochem. 20, 1351 (1988) Abstract
Microbial metabolites of ophiobolin A and antimicrobial evaluation of ophiobolins: E. Li, et al.; J. Nat. Prod. 58, 74 (1995) Abstract
The biology of ophiobolins: T.K. Au, et al.; Life Sci. 67, 733 (2000), Review Abstract
Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis: S. Quetglas, et al.; EMBO J. 21, 3970 (2002) Abstract; Full Text
Herbicidal potential of ophiobolins produced by Drechslera gigantea: A. Evidente, et al.; J. Agric. Food Chem. 54, 1779 (2006) Abstract
Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products: N. Yoshida, et al.; Food Chem. Toxicol. 44, 2033 (2006) Abstract

Further Categories Containing This Product:

Calmodulin Inhibitors • Phosphodiesterases / Related Products • Natural Products with Antibiotic Activity • MDR Inhibitors • P-glycoprotein [Pgp] / Related Products • Other Toxins • Natural Products - Antitumor Reagents

ALX-270-264

Revised 17-Apr-08

Carnosic acid
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-264-M010		10 mg	45.00 USD
ALX-270-264-M050		50 mg	140.00 USD

Product Specification

FORMULA:	C₂₀H₂₈O₄
MW:	332.4
CAS NUMBER:	3650-09-7
SOURCE/HOST:	Isolated from Rosmarinus officinalis.
PURITY:	≥95%
APPEARANCE:	Yellow powder.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Naturally occurring phenolic compound with antioxidant properties. Inhibits lipid peroxidation induced by NADH or NADPH oxidation. Peroxisome proliferator-activated receptor γ (PPARγ) activator. Anti-inflammatory. Antimicrobial.

Product Specific Literature References

Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes: K. Schwarz & W. Ternes; Z. Lebensm. Unters. Forsch. 195, 99 (1992) Abstract
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid: O.I. Aruoma, et al.; Xenobiotica 22, 257 (1992) Abstract
Radical intermediates and antioxidants: an ESR study of radicals formed on carnosic acid in the presence of oxidized lipids: M. Geoffroy, et al.; Free Radic. Res. 21, 247 (1994) Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis: H. Haraguchi, et al.; Planta Med. 61, 333 (1995) Abstract
Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells: E.A. Offord, et al.; Carcinogenesis 16, 2057 (1995) Abstract
Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx and carnosic acid: A.I. Kuzmenko, et al.; J. Photochem. Photobiol. B 48, 63 (1999) Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006) Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007) Abstract

Further Categories Containing This Product:

Lipid Peroxidation • Active Substances from Fruit and Vegetables • Natural Products with Antibiotic Activity • Natural Products - Anti-inflammatory Agents • PPAR Agonists

ALX-350-077

Revised 30-Jun-08

Swainsonine
SYNONYMS	8α,β-Octahydroindolizidine-1α,2α,8β-triol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-077-MC05		0.5 mg	85.00 USD
ALX-350-077-M001		1 mg	148.00 USD

Product Specification

FORMULA:	C₈H₁₅NO₃
MW:	173.2
CAS NUMBER:	72741-87-8
SOURCE/HOST:	Synthetic.
PURITY:	≥98% (TLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO, methanol or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Reversibly inhibits the active site of lysosomal α-mannosidase. Also inhibits the growth of tumors and prevents metastasis in murine models. Could inhibit cell proliferation in vitro and the growth of human gastric carcinoma in vivo. Blocks the processing of high mannose oligosaccharides to form complex type oligosaccharides.

Product Specific Literature References

Inhibitors of glycoprotein synthesis: A.D. Elbein; Meth. Enzymol. 98, 135 (1983) Abstract
Purification and characterization of Ca2+/calmodulin-dependent protein kinase V from rat cerebrum: H. Mochizuki, et al.; J. Biol. Chem. 268, 9143 (1993) Abstract; Full Text
Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity: J.L. Klein, et al.; Br. J. Cancer 80, 87 (1999) Abstract
Swainsonine stimulates bone marrow cell proliferation and differentiation in different strains of inbred mice: O.A. Oredipe, et al.; Pharmacol. Res. 47, 69 (2003) Abstract
Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine: J.Y. Sun, et al.; Phytomedicine 14, 353 (2007) Abstract

Further Categories Containing This Product:

Natural Products with Antibiotic Activity • Glycosidases / Related Products • Alkaloids

ALX-350-094

Revised 24-Jul-08

Berberine . hemisulfate
SYNONYMS	Natural Yellow 18 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products with Antibiotic Activity

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-094-G001		1 g	15.00 USD

Product Specification

FORMULA:	C₂₀H₁₈NO₄. 0.5SO₄
MW:	336.4 . 48.0
CAS NUMBER:	633-66-9
MERCK INDEX:	14: 1154
RTECS:	DR9867000
PURITY:	≥98% (TLC)
APPEARANCE:	Off-white to yellow powder.
SOLUBILITY:	50mg/ml soluble in methanol:water 2:1.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	TOXIC.
IDENTITY:	Determined by IR: Identical to standard reference.

Product Description

Alkaloid which exhibits relatively weak antibiotic properties, because of its efflux by multidrug resistance pumps. The antimicrobial action of berberine is potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor. Lowers cholesterol levels through a mechanism different from that of statins. Upregulates the expression of liver low-density lipoprotein receptor (LDLR) resulting in improved clearance of plasma LDL cholesterol through receptor mediated endocytosis. Possesses anti-inflammatory, anti-diabetic and anti-angiogenic effects. Induces apoptosis.

Product Specific Literature References

Berberine sulfate: antimicrobial activity, bioassay, and mode of action: A.H. Amin, et al.; Can. J. Microbiol. 15, 1067 (1969) Abstract
Bacteria lacking a multidrug pump: a sensitive tool for drug discovery: P.C. Hsieh, et al.; PNAS 95, 6602 (1998) Abstract; Full Text
Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5’-methoxyhydnocarpin, a multidrug pump inhibitor: F.R. Stermitz, et al.; PNAS 97, 1433 (2000) Abstract; Full Text
Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins: W. Kong, et al.; Nat. Med. 10, 1344 (2004) Abstract
The anti-inflammatory potential of berberine in vitro and in vivo: C.L. Kuo, et al.; Cancer Lett. 203, 127 (2004) Abstract
Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion: S.H. Leng, et al.; Acta Pharmacol. Sin. 25, 496 (2004) Abstract
Berberine inhibits HIF-1alpha expression via enhanced proteolysis: S. Lin, et al.; Mol. Pharmacol. 66, 612 (2004) Abstract
Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3: C.C. Lin, et al.; Anticancer Res. 26, 227 (2006) Abstract
Berberine acutely inhibits insulin secretion from beta cells through cAMP signaling pathway: L. Zhou, et al.; Endocrinology (2008) Abstract
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.: M.K. Pandey, et al.; Cancer Res. 68, 5370 (2008) Abstract

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Natural Products - Anti-inflammatory Agents • Antidiabetic Agents / Related Products • Cholesterol & Lipid Transport / Related Products • Alkaloids

ALX-350-097

Revised 16-Jun-08

Hyperforin . dicyclohexylammonium salt (high purity)
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Neurological Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-097-C500		500 µg	130.00 USD
ALX-350-097-M001		1 mg	210.00 USD

Product Specification

FORMULA:	C₃₅H₅₁O₄ . C₁₂H₂₄N
MW:	535.8 . 182.3
CAS NUMBER:	11079-53-1 (non-salt form)
SOURCE/HOST:	Isolated from St. John's wort (Hypericum perforatum).
PURITY:	≥97% (HPLC)
APPEARANCE:	White to off-white powder.
PURITY DETAIL:	Contains <3% adhyperforin.
SOLUBILITY:	Soluble in DMSO, methanol or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep under inert gas. Protect from light.

Product Description

Major constituent of St. John’s wort, a herbal remedy widely used for the treatment of depression. Inhibits the reuptake of neurotransmitters in synapses. Activator of the pregnane X receptor (PXR), which serves as a key regulator of CYP3A4 transcription, a member of the cytochrome (CYP) P450 enzyme system. Specifically activates TRPC6 channels. Represents an interesting lead-structure for a new class of antidepressants. Displays several other biological properties of potential pharmacological interest, including antibacterial, anti-inflammational, antitumoral and anti-angiogenic effects. Induces apoptosis in various cancer cells.

Product Specific Literature References

Hyperforin as a possible antidepressant component of hypericum extracts: S.S. Chatterjee, et al.; Life Sci. 63, 499 (1998) Abstract
Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat: S. Chatterjee, et al.; Life Sci. 65, 2395 (1999) Abstract
Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria: C.M. Schempp, et al.; Lancet 353, 2129 (1999) Abstract
Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1: A. Singer, et al.; J. Pharmacol. Exp. Ther. 290, 1363 (1999) Abstract
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor: L.B. Moore, et al.; PNAS 97, 7500 (2000) Abstract
Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression: R.S. Obach; J. Pharmacol. Exp. Ther. 294, 88 (2000) Abstract
St John's wort, a herbal antidepressant, activates the steroid X receptor: J.M. Wentworth, et al.; J. Endocrinol. 166, R11 (2000) Abstract
St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties: J. Barnes, et al.; J. Pharm. Pharmacol. 53, 583 (2001), (Review) Abstract
St John's wort: Prozac from the plant kingdom: G. Di Carlo, et al.; TIPS 22, 292 (2001), (Review) Abstract
Effect of St. John's wort on free radical production: E.J. Hunt, et al.; Life Sci. 69, 181 (2001) Abstract
Hypericum perforatum (St John's Wort): a non-selective reuptake inhibitor? A review of the recent advances in its pharmacology: P.J. Nathan; J. Psychopharmacol. 15, 47 (2001), (Review) Abstract
Aristoforin, a novel stable derivative of hyperforin, is a potent anticancer agent: M. Gartner, et al.; Chembiochem 6, 171 (2005) Abstract
Hyperforin, a new lead compound against the progression of cancer and leukemia?: C. Quiney, et al.; Leukemia 20, 1519 (2006), (Review) Abstract
Hyperforin a key constituent of St. John’s wort specifically activates TRPC6 channels: K. Leuner, et al.; FASEB J. 21, 4101 (2007) Abstract

Further Categories Containing This Product:

Other Natural Products - DNA Regulation / Transcription • Pregnane X Receptor [PXR] / Related Products • Natural Products - Anti-inflammatory Agents • Natural Products for Angiogenesis Research • Natural Products - Antitumor Reagents • Natural Products with Antibiotic Activity • Neuroactive Agents Other Products • Antitumor Agents (Apoptosis Inducers) • Natural Products - Apoptosis Inducers & Inhibitors

ALX-350-109

Revised 29-Nov-07

Panepoxydone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - NF-kB Pathway Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-109-MC05		0.5 mg	390.00 USD

Product Specification

FORMULA:	C₁₁H₁₄O₄
MW:	210.2
SOURCE/HOST:	Isolated from Lentinus crinitus.
PURITY:	>95% (HPLC)
FORMULATION:	Yellow oil
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Protect from light. Keep cool and dry.
HAZARD:	TOXIC.

Product Description

Antibiotic. Inhibitor of NF-κB activation by preventing the phosphorylation of IκB protein and thereby interrupts the signalling pathway. Strongly inhibits the expression of several NF-κB dependent pro-inflammatory genes.

Product Specific Literature References

Inhibition of NF-kappa B activation by panepoxydone: G. Erkel, et al.; BBRC 226, 214 (1996) Abstract
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways: H. Kleinert, et al.; Br. J. Pharmacol. 125, 193 (1998) Abstract
Naturally occurring and synthetic inhibitors of NF-kappaB functions: K. Umezawa, et al.; Anticancer Drug Des. 15, 239 (2000) Abstract
Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent: J.B. Shotwell, et al.; Bioorg. Med. Chem. Lett. 12, 3463 (2002) Abstract
Molecular design and biological activities of NF-kappaB inhibitors: K. Umezawa & C. Chaicharoenpong; Mol. Cells 14, 163 (2002) Abstract
Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells: G. Erkel, et al.; Int. Immunopharmacol. 7, 612 (2007) Abstract

Further Categories Containing This Product:

Natural Products - Anti-inflammatory Agents • Natural Products with Antibiotic Activity • NF-kB Pathway Inhibitors

ALX-350-110

Revised 08-Apr-08

Nidulal
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-110-MC05		0.5 mg	185.00 USD

Product Specification

FORMULA:	C₁₅H₁₆O₅
MW:	276.3
SOURCE/HOST:	Isolated from Nidula candida.
PURITY:	≥95%
APPEARANCE:	Lyophilized
SOLUBILITY:	Soluble in 100% ethanol, methanol or DMSO.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Keep cool and dry. Protect from light.
HAZARD:	TOXIC.

Product Description

Induces differentiation of human promyelocytic leukemia cells. In COS-7 cells selectively activates AP-1 dependent signal transduction in a manner similar to TPA/PMA (Prod. No. ALX-445-004).

Product Specific Literature References

Nidulal, a novel inducer of differentiation of human promyelocytic leukemia cells from Nidula candida: G. Erkel, et al.; J. Antibiot. 49, 1189 (1996) Abstract

Further Categories Containing This Product:

Natural Products with Antibiotic Activity • Natural Products - Apoptosis Inducers & Inhibitors

ALX-350-124

Revised 05-Apr-08

Ferulenol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products with Antibiotic Activity

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-124-M001		1 mg	45.00 USD
ALX-350-124-M005		5 mg	135.00 USD
ALX-350-124-M010		10 mg	230.00 USD

Product Specification

FORMULA:	C₂₄H₃₀O₃
MW:	366.5
CAS NUMBER:	6805-34-1
SOURCE/HOST:	Isolated from Ferula communis.
PURITY:	≥96%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO, 100% ethanol and methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Prenylated 4-hydroxycoumarin. Antitubercular antibiotic with potent activity against Mycobacteria. Exerts taxol-like and dose-dependent cytotoxicity against various human tumor cell lines. Stimulator of tubulin polymerisation in vitro and inhibitor of colchicine binding to tubulin. Antithrombotic, depressing the activity of all vitamin K-dependent coagulation factors. Shows lower acute toxicity and higher activity than warfarin. Shows hepatocyte toxicity.

Product Specific Literature References

Experimental studies on the toxicity of some compounds isolated from Ferula communis in the rat: S. Tagliapietra, et al.; Res. Commun. Chem. Pathol. Pharmacol. 66, 333 (1989) Abstract
Plasma ferulenol concentration and activity of clotting factors in sheep with Ferula communis variety brevifolia intoxication: N. Tligui, et al.; Am. J. Vet. Res. 55, 1564 (1994) Abstract
Antibacterial constituents from the rhizomes of Ferula communis: M.A. Al-Yahya, et al.; Phytother. Res. 12, 335 (1998)
Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol: C. Bocca, et al.; Planta Med. 68, 1135 (2002) Abstract
Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L: O. Fraigui, et al.; Vet. Hum. Toxicol. 44, 5 (2002) Abstract
Characterization of anti-coagulant properties of prenylated coumarin ferulenol: M. Monti, et al.; Biochim. Biophys. Acta 1770, 1437 (2007) Abstract

Further Categories Containing This Product:

ALX-350-144

Revised 03-Apr-08

Bakuchiol
SYNONYMS	4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-144-M001		1 mg	170.00 USD