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Acetylcholine Esterase / Related Products
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ALX-550-345 Revised 20-Nov-02
(-)-Eseroline . fumarate
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Esterase / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-345-M010   10 mg 30.00 USD Add To Cart
ALX-550-345-M050   50 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C13H18N2O . C4H4O4
MW: 218.3 . 116.1
CAS NUMBER: 104015-29-4
PURITY: ≥97%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water or DMSO. Slightly soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Hygroscopic.

Product Description
Metabolite of physostigmine (eserine) (Prod. No. ALX-550-364). Potent analgesic.
Product Specific Literature References
Direct evidence that eseroline possesses morphine-like effects: S. Fürst, et al.; Eur. J. Pharmacol. 83, 233 (1982) Abstract
Reversible inhibition of acetylcholinesterase by eseroline, an opioid agonist structurally related to physostigmine (eserine) and morphine: A. Galli, et al.; Biochem. Pharmacol. 31, 1233 (1982) Abstract
In-vitro and in-vivo protection of acetylcholinesterase by eseroline against inactivation by diisopropyl fluorophosphate and carbamates: A. Galli, et al.; J. Pharm. Pharmacol. 37, 42 (1985) Abstract
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products
 
 
ALX-550-336 Revised 18-Sep-07
Galanthamine . hydrobromide
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SYNONYMS Galantamine
Nivalin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-550-336-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C17H21NO3 . HBr
MW: 287.4 . 80.9
CAS NUMBER: 1953-04-4
MERCK INDEX: 14: 4340
RTECS: DF8075000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from moisture.
HAZARD: TOXIC.

Product Description
Specific, competitive and reversible acetylcholinesterase inhibitor. Alzheimer's disease therapeutic.
Product Specific Literature References
Galanthamine treatment in Alzheimer's disease: P. Dal-Bianco, et al.; J. Neural. Transm. Suppl. 33, 59 (1991) Abstract
Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats: P. Chopin & M. Briley; Psychopharmacology 106, 26 (1992) Abstract
Galanthamine from snowdrop-the development of a modern drug against Alzheimer's disease from local Caucasian knowledge.: M. Heinrich & H. Lee Teoh; J. Ethnopharmacol 92, 147 (2004) Abstract
Acetylcholinesterase inhibitors: novel activities of old molecules.: M. Racchi, et al.; Pharmacol. Res. 50, 441 (2004) Abstract
Further Categories Containing This Product:
Acetylcholine Esterase / Related Products • Alkaloids
 
 
ALX-550-064 Revised 07-Oct-08
(±)-Huperzine A
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SYNONYMS (±)-Selagine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cholinergics / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-064-M001   1 mg 50.00 USD Add To Cart
ALX-550-064-M005   5 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C15H18N2O
MW: 242.3
CAS NUMBER: 120786-18-7
MERCK INDEX: 14: 4755
SOURCE/HOST: Synthetic.
PURITY: ≥95%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in dilute aqueous acids or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.
Product Description

Racemic modification of (-)-Huperzine A (Prod. No. ALX-550-065) with acetylcholinesterase inhibitor activity. Has a weaker biological activity than (-)Huperzine A. Neurotoxic.
Product Specific Literature References
The effect of the nucleoside transport inhibitor dipyridamole on the incorporation of [3H]thymidine in the rat: J.-S. Liu, et al.; Can. J. Chem. 64, 837 (1986)
A practical synthesis of the Chinese "nootropic" agent huperzine A: a possible lead in the treatment of Alzheimer's disease: Y. Xia & A.P. Kozikowski; JACS 111, 4116 (1989)
Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat: X.C. Tang, et al.; J. Neurosci. Res. 24, 276 (1989) Abstract
Synthesis and Biological Evaluation of (±)-Z-Huperzine A: A.P. Kozikowski, et al.; Tetrahedron Lett. 31, 6159 (1990)
Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase: M. McKinney, et al.; Eur. J. Pharmacol. 203, 303 (1991) Abstract
Mechanism of inhibition of cholinesterases by huperzine A: Y. Ashani, et al.; BBRC 184, 719 (1992) Abstract
An Improved Synthetic Route to Huperzine A; New Analogues and Their Inhibition of Acetylcholinesterase: A.P. Kozikowski, et al.; J. C. S. Chem. Commun. 860 (1993)
Huperzine A ameliorates the spatial working memory impairments induced by AF64A: Q.X. Zhi, et al.; NeuroReport 6, 2221 (1995) Abstract
Huperzine A, a potential therapeutic agent for treatment of Alzheimer’s disease: D.L. Bai, et al.; Curr. Med. Chem. 7, 355 (2000), (Review) Abstract
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine: R. Wang, et al.; Acta Pharmacol. Sin. 27, 1 (2006) Abstract
Further Categories Containing This Product:
Alkaloids • Acetylcholine Esterase / Related Products
 
 
ALX-550-065 Revised 07-Oct-08
(-)-Huperzine A
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SYNONYMS (-)-Selagine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Cholinergics / Related Products
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ALX-550-065-MC05   0.5 mg 60.00 USD Add To Cart
ALX-550-065-M001   1 mg 100.00 USD Add To Cart
Product Specification
FORMULA: C15H18N2O
MW: 242.3
CAS NUMBER: 102518-79-6
MERCK INDEX: 14: 4755
RTECS: PB9185700
SOURCE/HOST: Isolated from Lycopodium sp.
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: VERY TOXIC.

Product Description
Plant alkaloid. Neurotoxin. Active isomer with acetylcholine esterase activity. Protects cells against hydrogen peroxide, β-amyloid, glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis. Prospective agent for the treatment of Alzheimer‘s disease. For the racemic modification, see (±)-Huperzine A (Prod. No. ALX-550-064).
Product Specific Literature References
The effect of the nucleoside transport inhibitor dipyridamole on the incorporation of [3H]thymidine in the rat: J.-S. Liu, et al.; Can. J. Chem. 64, 837 (1986)
Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat: X.C. Tang, et al.; J. Neurosci. Res. 24, 276 (1989) Abstract
A Practical Synthesis of the Chinese "Nootropic" Agent Huperzine A: A Possible Lead in the Treatment of Alzheimer's Disease: Y. Xia & A.P. Kozikowski; JACS 111, 4116 (1989)
Synthesis and Biological Evaluation of (±)-Z-Huperzine A: A.P. Kozikowski, et al.; Tetrahedron Lett. 31, 6159 (1990)
Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase: M. McKinney, et al.; Eur. J. Pharmacol. 203, 303 (1991) Abstract
Mechanism of inhibition of cholinesterases by huperzine A: Y. Ashani; BBRC 184, 719 (1992) Abstract
Natural and synthetic Huperzine A: effect on cholinergic function in vitro and in vivo: I. Hanin, et al.; Ann. N. Y. Acad. Sci. 695, 304 (1993) Abstract
An Improved Synthetic Route to Huperzine A; New Analogues and Their Inhibition of Acetylcholinesterase: A.P. Kozikowski, et al.; J. C. S. Chem. Commun. 860 (1993)
Huperzine A, a potential therapeutic agent for treatment of Alzheimer’s disease: D.L. Bai, et al.; Curr. Med. Chem. 7, 355 (2000), (Review) Abstract
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine: R. Wang, et al.; Acta Pharmacol. Sin. 27, 1 (2006), (Review) Abstract
Further Categories Containing This Product:
Alzheimer Research Other Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products for Neurological Research • Alkaloids • Acetylcholine Esterase / Related Products
 
 
ALX-802-004 Revised 18-Feb-08
Monoclonal Antibody to Acetylcholinesterase (ZR3)
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SYNONYMS anti-AChE MAb (ZR3)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Esterase / Related Products
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ALX-802-004-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Rat
Others
CLONE: ZR3
ISOTYPE: Mouse IgG2b
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Purified rat brain AChE (acetylcholinesterase).
SPECIFICITY: Recognizes rat, guinea pig, rabbit and cat AChE. Does not cross-react with BChE (butyrylcholinesterase).
APPLICATION: Immunohistochemistry (1:1'000)
Immunoprecipitation
Not recommended for Western blot.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Monoclonal antibodies to rat brain acetylcholinesterase: comparative affinity for soluble and membrane-associated enzyme and for enzyme from different vertebrate species: Z. Rakonczay and S. Brimijoin; Neurochemistry 46, 280 (1986) Abstract
Selective destruction of preganglionic sympathetic nerves by antibodies to acetylcholinesterase: S. Brimijoin and V.A. Lennon; J. Neural Transm. Suppl. 34, 139 (1991) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Reacts with both the soluble and membrane-associated AChE. Immunohistochemical staining of AChE in rat brain results in staining of nerve fibers and terminals.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-802-003 Revised 10-Dec-07
Monoclonal Antibody to Acetylcholinesterase (HR2)
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SYNONYMS anti-AChE MAb (HR2)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Esterase / Related Products
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ALX-802-003-R200   200 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
CLONE: HR2
ISOTYPE: Mouse IgG2b
FORMULATION: Liquid. Diluted ascites in PBS containing 0.05% sodium azide.
IMMUNOGEN: Purified human brain AChE (acetylcholinesterase).
SPECIFICITY: Recognizes human, rabbit, guinea pig, bovine and cat AChE. Does not cross-react with BChE (butyrylcholinesterase).
APPLICATION: ELISA
Immunohistochemistry (frozen sections (1:50))
Immunoprecipitation
Note: Not suitable for Western blot.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Monoclonal antibodies to human brain acetylcholinesterase: properties and applications: Z. Rakonczay and S. Brimijoin; Cell. Mol. Neurobiol. 8, 85 (1988)
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-270-184 Revised 26-May-08
Phenylmethylsulfonyl fluoride
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SYNONYMS PMSF
Benzylsulfonyl fluoride
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Proteases Other Products
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ALX-270-184-G001   1 g 25.00 USD Add To Cart
ALX-270-184-G005   5 g 50.00 USD Add To Cart
ALX-270-184-G025   25 g 135.00 USD Add To Cart
Product Specification
FORMULA: C7H7FO2S
MW: 174.2
CAS NUMBER: 329-98-6
RTECS: XT8040000
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white needle crystals.
SOLUBILITY: Soluble in 100% ethanol, methanol or isopropanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: CORROSIVE. HARMFUL.

Product Description
Irreversible inhibitor of serine proteases. Widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity. Spleen membranes used for CB2 studies do not require this pretreatment, as FAAH activity is absent in these cells. Inhibits also cysteine proteases like papain (reversible by DTT treatment, Prod. No. ALX-280-001), as well as internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor see AEBSF (Prod. No. ALX-270-022).
Product Specific Literature References
Kinetic analysis of differences in brain acetylcholinesterase from fish or mammalian sources: D.E. Moss & D.E. Fahrney; Biochem. Pharmacol. 27, 2693 (1978) Abstract
Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers: G.T. James; Anal. Biochem. 86, 574 (1978) Abstract
Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist: D.G. Deutsch & S.A. Chin; Biochem. Pharmacol. 46, 791 (1993) Abstract
Further Categories Containing This Product:
Acetylcholine Esterase / Related Products • Fatty Acid Amide Hydrolase [FAAH] / Related Products
 
 
ALX-550-364 Revised 26-May-03
Physostigmine
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SYNONYMS Eserine
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Acetylcholine Esterase / Related Products
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ALX-550-364-M100   100 mg 20.00 USD Add To Cart
Product Specification
FORMULA: C15H21N3O2
MW: 275.3
CAS NUMBER: 57-47-6
MERCK INDEX: 14: 7384
PURITY: ≥99%
APPEARANCE: Crystalline solid.
SOLUBILITY: Soluble in chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and air.
HAZARD: TOXIC.

Product Description
Forms a carbamylated enzyme complex with acetylcholinesterase (AChE) that degrades slowly. Crosses blood-brain barrier.
 
 
ALX-630-117 Revised 07-Oct-08 New product
Territrem B
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-117-MC05   0.5 mg 145.00 USD Add To Cart
ALX-630-117-M001   1 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C29H34O9
MW: 526.6
CAS NUMBER: 70407-20-4
RTECS: QL6284000
SOURCE/HOST: Isolated from Aspergillus terreus.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Tremorgenic mycotoxin. Potent and specific, noncovalent yet irreversible inhibitor of acetylcholinesterase (IC50=8nM).
Product Specific Literature References
Territrems, tremorgenic mycotoxins of Aspergillus terreus: K.H. Ling, et al.; Appl. Environ. Microbiol. 37, 355 (1979) Abstract; Full Text
Biosynthesis of Territrems by Aspergillus terreus: K.H Ling & Y.W. Peng; Appl. Environ. Microbiol. 54, 585 (1988) Abstract; Full Text
Effects of territrem-B on cholinergic responses of snail neuron: V.L. Arvanov, et al.; Neurosci. Lett. 152, 69 (1993) Abstract
Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. I. Screening, taxonomy, fermentation, isolation and biological activity: F. Kuno, et al.; J. Antibiot. 49, 742 (1996) Abstract
Territrems: Naturally Occurring Specific Irreversible Inhibitors of Acetylcholinesterase: J.W. Chen & K.H. Ling; J. Biomed. Sci. 3, 54 (1996) Abstract
Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism: J.W. Chen, et al.; J. Biol. Chem. 274, 34916 (1999) Abstract; Full Text
Territrems B and C metabolism in human liver microsomes: major role of CYP3A4 and CYP3A5: F.C. Peng, et al.; Toxicology 218, 172 (2006) Abstract
General Information
MANUFACTURER Manufactured by the Kitasato Institute, Tokyo.
Further Categories Containing This Product:
Acetylcholine Esterase / Related Products
 
 
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