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Granzyme Inhibitors
You are here: Product Lines > Cell Death / Apoptosis / Autophagy > Granzymes / Related Products > Granzyme Inhibitors
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ALX-260-056 Revised 11-Dec-07
Ac-ESMD-CHO
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SYNONYMS Caspase-8 Inhibitor (Aldehyde)
Granzyme B Inhibitor (Aldehyde)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-056-M001   1 mg 83.00 USD Add To Cart
ALX-260-056-M005   5 mg 325.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Glu-Ser-Met-Asp-CHO
FORMULA: C19H30N4O10S
MW: 506.5
PEPTIDE CONTENT: 70-90%.
PURITY: ≥99% (HPLC)
APPEARANCE: White powder.
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in distilled water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Use always fresh solutions.
HANDLING: Keep cool and dry. Keep under inert gas.
Product Description
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-6 and -10. The peptide sequence corresponds to one of the cleavage sites of the inactive 32kDa caspase-3 precursor (aa 25-28). It blocks the formation of the p17 subunit and concomitantly induces the accumulation of the p20 peptide.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997) Abstract; Full Text
Further Categories Containing This Product:
Granzyme Inhibitors
 
 
ALX-260-043 Revised 13-Nov-06
Ac-IETD-CHO
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SYNONYMS Caspase-8 Inhibitor (Aldehyde)
Granzyme B Inhibitor (Aldehyde)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-043-M001   1 mg 62.00 USD Add To Cart
ALX-260-043-M005   5 mg 243.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Ile-Glu-Thr-Asp-CHO
FORMULA: C21H34N4O10
MW: 502.5
PEPTIDE CONTENT: 70-90%.
PURITY: ≥97% (HPLC)
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Use always fresh solutions.
HANDLING: Keep cool and dry.
Product Description
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-10.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997) Abstract; Full Text
Further Categories Containing This Product:
Granzyme Inhibitors
 
 
ALX-260-153 Revised 07-Nov-05
Z-AAD-CMK (Ready-to-Use)
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SYNONYMS Granzyme B Inhibitor (Ready-to-Use)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-153-R020 10mM 20 µl 175.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Ala-Ala-Asp-chloromethylketone
MW: 441.9
CONCENTRATION: 10mM
PURITY: ≥96% (HPLC)
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Synthetic peptide that irreversibly inhibits granzyme B activity. The inhibitor is desigend as a methyl ester to facilitate cell permeability.
Further Categories Containing This Product:
Granzyme Inhibitors
 
 
ALX-260-073 Revised 20-Aug-07
Z-IE(OMe)TD(OMe)-FMK
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SYNONYMS Caspase-8 Inhibitor (Fluoromethylketone)
Granzyme B Inhibitor (Fluoromethylketone)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-073-M001   1 mg 220.00 USD Add To Cart
ALX-260-073-M005   5 mg 660.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone
FORMULA: C30H43FN4O11
MW: 654.7
PURITY: ≥90% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Store stock solutions in aliquots at -20°C.
HANDLING: Packaged under inert gas.
Product Description
Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10.
Product Specific Literature References
Role of caspases in immunotoxin-induced apoptosis of cancer cells: A. Keppler-Hafkemeyer, et al.; Biochemistry 37, 16934 (1998) Abstract
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal: D.A. Martin, et al.; J. Biol. Chem. 273, 4345 (1998) Abstract; Full Text
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide: E.A. Sweeney, et al.; FEBS Lett. 425, 61 (1998) Abstract
Caspase-mediated proteolysis and activation of protein kinase Cδ plays a central role in neutrophil apoptosis: A. Khwaja & L. Tatton; Blood 94, 291 (1999) Abstract; Full Text
Reconstitution of caspase-8 sensitizes JB6 cells to TRAIL: I.K. Kim, et al.; BBRC 277, 311 (2000) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
Further Categories Containing This Product:
Granzyme Inhibitors
 
 
ALX-260-144 Revised 01-Sep-05
Z-IETD-FMK (Ready-to-Use)
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SYNONYMS Caspase-8 Inhibitor (Fluoromethylketone) (Ready-to-Use)
Granzyme B Inhibitor (Fluoromethylketone) (Ready-to-Use)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-144-R100 2mM 100 µl 161.00 USD Add To Cart
ALX-260-144-R020 10mM 20 µl 161.00 USD Add To Cart
Product Specification
SEQUENCE: Z-Ile-Glu-Thr-Asp-fluoromethylketone
MW: 654.0
PURITY: ≥99% (HPLC)
FORMULATION: Liquid. In DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10.
General Information
BACKGROUND/TECHNICAL INFORMATION We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
Further Categories Containing This Product:
Granzyme Inhibitors
 
 
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