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Items 17 of 17
ALX-201-006
Revised 04-Sep-08
N-Acetyl-eglin C (recombinant)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-006-MC01
0.1 mg
95.00 USD
ALX-201-006-MC05
0.5 mg
380.00 USD
ALX-201-006-M001
1 mg
670.00 USD
Product Specification
SEQUENCE:
Ac-Thr-Glu-Phe-Gly-Ser-Glu-Leu-Lys-Ser-Phe-Pro-Glu-Val-Val-Gly-Lys-Thr-Val-Asp-Gln-Ala-Arg-Glu-Tyr-Phe-Thr-Leu-His-Tyr-Pro-Gln-Tyr-Asn-Val-Tyr-Phe-Leu-Pro-Glu-Gly-Ser-Pro-Val-Thr-Leu-Asp-Leu-Arg-Tyr-Asp-Arg-Val-Arg-Val-Phe-Tyr-Asn-Pro-Gly-Thr-Asn-Val-Val-Asn-His-Val-Pro-His-Val-Gly-OH
FORMULA:
C
377
H
552
N
96
O
107
MW:
8141.1
CAS NUMBER:
96380-69-7
SOURCE/HOST:
Produced in
E. coli
.
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Eglin C was originally isolated from the leech
Hirudo medicinalis
[1]. Recombinant N-acetyl-eglin C is a 70 amino acid peptide with identical biological activity to native eglin C. An effective inhibitor of chymotrypsin and subtilisin as well as of leukocyte elastase and cathepsin G.
Product Specific Literature References
[1]
Structure of the elastase-cathepsin G inhibitor of the leech Hirudo medicinalis:
U. Seemüller, et al.; Hoppe-Seyler's Z. Physiol. Chem.
361
, 1841 (1980)
Abstract
[2]
A large fragment approach to DNA synthesis: total synthesis of a gene for the protease inhibitor eglin c from the leech Hirudo medicinalis and its expression in E. coli:
H. Rink, et al.; Nucl. Acids Res.
12
, 6369 (1984)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P01051:
Eglin C (Hirudo medicinalis)
Further Categories Containing This Product:
Proteases Other Products
•
Recombinant Proteins / Fusion Proteins
ALX-260-136
Revised 16-Jun-05
H-Arg-Lys-Leu-Leu-Trp-NH2
SYNONYMS
RKLLW-NH
2
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
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Quantity:
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ALX-260-136-M001
1 mg
30.00 USD
ALX-260-136-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
35
H
59
N
11
O
5
MW:
713.9
PURITY:
≥98%
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Highly potent peptide inhibitor of human cathepsin L.
Product Specific Literature References
Highly potent inhibitors of human cathepsin L identified by screening combinatorial pentapeptide amide collections::
A. Brinker, et al.; Eur. J. Biochem.
267
, 5085 (2000)
Abstract
ALX-620-080
Revised 23-May-06
bADA
SYNONYMS
Dibenzyl-1-[(R)-biotin-6-aminohexanoyl-aziridine]-2,3-(S,S+R,R)-dicarboxylate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-620-080-M002
2 mg
540.00 USD
Product Specification
FORMULA:
C
34
H
42
N
4
O
7
S
MW:
650.8
CAS NUMBER:
744207-03-02
PURITY:
≥98% (HPLC)
APPEARANCE:
White to yellow solid.
SOLUBILITY:
Soluble in DMSO (50mg/ml), 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Irreversible, cell permeable, biotin-labelled inhibitor of cysteine proteases.
Product Specific Literature References
Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate:
C. Gelhaus, et al.; Biol. Chem.
385
, 435 (2004)
Abstract
Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells:
C. Gelhaus, et al.; Biol. Chem.
386
, 499 (2005)
Abstract
Further Categories Containing This Product:
Cathepsin Inhibitors
ALX-260-017
Revised 07-Jul-08
CA-074
SYNONYMS
N-[L-3-
trans
-Propylcarbamoyloxirane-2-carbonyl]-Ile-Pro-OH
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
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ALX-260-017-M001
1 mg
210.00 USD
Product Specification
FORMULA:
C
18
H
29
N
3
O
6
MW:
383.5
CAS NUMBER:
134448-10-5
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in ethyl acetate (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent and specific inhibitor of cathepsin B
in vitro
and
in vivo
.
Product Specific Literature References
Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro:
M. Murata, et al.; FEBS Lett.
280
, 307 (1991)
Abstract
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo:
T. Towatari, et al.; FEBS Lett.
280
, 311 (1991)
Abstract
Specific assay method for the activities of cathepsin L-type cysteine proteinases:
T. Inubushi, et al.; J. Biochem.
116
, 282 (1994)
Abstract
ALX-260-037
Revised 30-May-07
Calpain Inhibitor I
SYNONYMS
Ac-LL-Norleucinal
Ac-Leu-Leu-Nle-CHO
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calpains / Related Products
Ordering Information
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ALX-260-037-M010
10 mg
80.00 USD
ALX-260-037-M050
50 mg
310.00 USD
Product Specification
FORMULA:
C
20
H
37
N
3
O
4
MW:
383.5
CAS NUMBER:
110044-82-1
SOURCE/HOST:
Synthetic.
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light and moisture.
Product Description
Inhibits calpain I (K
i
=190nM), calpain II (K
i
=220nM), cathepsin B (K
i
=150nM) and cathepsin L (K
i
=0.5nM). Inhibits neutral cysteine proteases and the proteasome. Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with the transcription of inducible nitric oxide synthase (iNOS; NOS II). Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex.
Product Specific Literature References
Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase gene:
J.M. Griscavage, et al.; BBRC
215
, 721 (1995)
Abstract
Further Categories Containing This Product:
Proteasome / Related Products
•
Cathepsin Inhibitors
•
Proteases Other Products
ALX-260-038
Revised 15-Nov-05
Calpain Inhibitor II
SYNONYMS
Ac-LLM-CHO
Ac-Leu-Leu-Met-CHO
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calpains / Related Products
Ordering Information
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ALX-260-038-M010
10 mg
75.00 USD
ALX-260-038-M050
50 mg
290.00 USD
Product Specification
FORMULA:
C
19
H
35
N
3
O
4
S
MW:
401.6
CAS NUMBER:
110115-07-6
PURITY:
≥96%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light and moisture.
Product Description
Inhibitor of calpain I, calpain II, cathepsin B and cathepsin L.
Further Categories Containing This Product:
Cathepsin Inhibitors
ALX-260-014
Revised 19-Aug-08
Calpeptin
SYNONYMS
Z-Leu-norleucinal
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calpains / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-260-014-M005
5 mg
85.00 USD
ALX-260-014-M010
10 mg
160.00 USD
Product Specification
FORMULA:
C
20
H
30
N
2
O
4
MW:
362.5
CAS NUMBER:
117591-20-5
PURITY:
≥94% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
5mg/ml soluble in DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 2 months when stored at -20°C.
HANDLING:
Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. Protect from light and moisture.
Product Description
Membrane permeable inhibitor of calpain I and II and cathepsin L. Promotes neurite elongation in differentiating PC12 cells. Prevents Ca
2+
-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin (Prod. No.
ALX-450-006
) or thrombin.
Product Specific Literature References
Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins:
T. Sasaki, et al.; J. Enz. Inhib.
3
, 195 (1990)
Abstract
Cell-penetrating inhibitors of calpain:
S. Mehdi; TIBS
16
, 150 (1991)
Abstract
Specificity of calcium-activated neutral proteinase (CANP) inhibitors for human mu CANP and mCANP:
K. Saito and R.A. Nixon; Neurochem. Res.
18
, 231 (1993)
Abstract
Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells:
M. Pinter, et al.; Neurosci. Lett.
170
, 91 (1994)
Abstract
Further Categories Containing This Product:
Cathepsin Inhibitors
ALX-260-005
Revised 03-Mar-05
Chymostatin
SYNONYMS
(S)-1-Carboxy-2-phenylethyl)-carbamoyl-α-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
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ALX-260-005-M001
1 mg
22.00 USD
ALX-260-005-M005
5 mg
75.00 USD
Product Specification
FORMULA:
C
21
H
38
N
4
O
8
MW:
605.0 (average)
CAS NUMBER:
9076-44-2
SOURCE/HOST:
Microbial.
SOLUBILITY:
Soluble in DMSO (20 mg/ml) or glacial acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of serine proteinases having a chymotrypsin-like specificity like α-, β-, δ- and γ-chymotrypsin, chymases, cathepsin G, and most cysteine proteinases including papain and cathepsin A, B, H, and L. Mixture of type A (R=L-Leu), type B (R=L-Val), type C (R=L-Ile).
Product Specific Literature References
Chymostatin, a new chymotrypsin inhibitor produced by actinomycetes:
H. Umezawa, et al.; J. Antibiot.
23
, 425 (1970)
Abstract
Further Categories Containing This Product:
Proteases Other Products
ALX-260-007
Revised 16-Feb-05
E-64
SYNONYMS
N-[N-(L-3-
trans
-Carboxyoxirane-2-carbonyl]-L-leucyl)-agmatine
L-
trans
-Epoxysuccinyl-leucylamide-(4-guanido)-butane
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
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ALX-260-007-M005
5 mg
55.00 USD
ALX-260-007-M025
25 mg
195.00 USD
Product Specification
FORMULA:
C
15
H
27
N
5
O
5
MW:
357.4
CAS NUMBER:
66701-25-5
SOURCE/HOST:
Synthetic.
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Irreversible inhibitor of cysteine proteinases like papain, cathepsin B and L. Acts by forming a thioether bond with the thiol of the active cysteine. Does not inhibit serine proteinases.
Product Specific Literature References
K. Hanada, et al.; Agric. Biol. Chem.
42
, 529 (1978)
K. Hanada, et al.; Agric. Biol. Chem.
42
, 523 (1978)
Further Categories Containing This Product:
Proteases Other Products
ALX-260-164
Revised 24-Sep-07
H-LVK-CHO
SYNONYMS
H-Leu-Val-Lys-CHO
Cathepsin B Inhibitor (Aldehyde)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
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ALX-260-164-M001
1 mg
70.00 USD
ALX-260-164-M005
5 mg
280.00 USD
Product Specification
FORMULA:
C
19
H
36
N
4
O
4
MW:
384.5
PURITY:
≥95%
APPEARANCE:
White to beige solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
May form cyclic isomers.
Product Description
Inhibitor of cathepsin B (IC
50
=4nM). More potent than to leupeptin (IC
50
=310nM) (Prod. No.
ALX-260-009
).
Product Specific Literature References
Inhibition studies of some serine and thiol proteinases by new leupeptin analogues:
R.M. McConnell, et al.; J. Med. Chem.
36
, 1084 (1993)
Abstract
ALX-270-280
Revised 07-Apr-08
clasto-Lactacystin β-lactone (synthetic)
SYNONYMS
Omuralide
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Proteasome / Ubiquitin Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-280-C200
200 µg
280.00 USD
ALX-270-280-M001
1 mg
1'295.00 USD
Product Specification
FORMULA:
C
10
H
15
NO
4
MW:
213.2
CAS NUMBER:
155975-72-7
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
20mg/ml soluble in DMSO or acetonitrile.
ACTIVITY:
K
obs
/[I]=20’000M
-1
s
-1
versus 20S:PA28 complex.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Subject to hydrolysis in aqueous buffers. We do not recommend storing the aqueous solutions for more than one day.
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR.
Product Description
Highly specific, cell permeable, and irreversible 20S proteasome inhibitor. Inhibits ubiquitin proteasome pathway in cell culture (IC
50
=1µM). It has been suggested that the natural product lactacystin acts as a precursor for
clasto
-lactacystin β-lactone and that the latter is the sole species that interacts with the proteasome. Inhibits cathepsin A. Leads to a reduction of adipogenes
