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Items 14 of 14
ALX-201-023
Revised 06-Aug-07
Cyclophilin A (human) (recombinant)
SYNONYMS
CyPA (human) (recombinant)
Peptidyl-prolyl
cis-trans
Isomerase A (human) (recombinant)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-201-023-C100
100 µg
586.00 USD
Product Specification
MW:
~18kDa.
EC:
5.2.1.8
SOURCE/HOST:
Produced in
E. coli
.
CONCENTRATION:
PURITY:
≥90%
FORMULATION:
Liquid. In 20mM TRIS-HCl, pH 7.8.
BIOLOGICAL ACTIVITY:
Catalyzes cis-trans-isomerization of X-Pro-peptide bonds. Accelerates protein folding reactions that are limited by the isomerization of X-Pro-peptide bonds.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P05092:
Cyclophilin A (human)
AfCS Signalling Gateway link A000735:
Cyclophilin A (mouse)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-201-150
Revised 05-Jul-06
Peptidyl-prolyl cis-trans Isomerase CPR6 (yeast) (recombinant)
SYNONYMS
CPR6 (yeast) (recombinant)
PPIase Cpr6 (yeast) (recombinant)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-150-C025
25 µg
290.00 USD
Product Specification
EC:
5.2.1.8
SOURCE/HOST:
Produced in
E. coli
.
CONCENTRATION:
23mg/ml
PURITY:
≥99%
FORMULATION:
Liquid. In 40mM HEPES/KOH, pH 7.5, containing 20mM potassium chloride.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Specific Literature References
Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties
:
C. Mayr, et al.; J. Biol. Chem.
275
, 34140 (2000)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P53691:
Peptidyl-prolyl cis-trans isomerase CPR6 (
Saccharomyces cerevisiae
(Baker's yeast))
General Literature References
Heat-shock protein 90, a chaperone for folding and regulation
:
D. Picard; Cell. Mol. Life Sci.
59
, 1640 (2002), (Review)
Abstract
Further Categories Containing This Product:
Enzymes
•
Recombinant Proteins / Fusion Proteins
ALX-201-270
Revised 18-Mar-08
Cyclophilin 40 (human) (recombinant) (His)
SYNONYMS
CyP-40 (human) (recombinant) (His)
Peptidyl-prolyl cis-trans Isomerase 40kDa (human) (recombinant) (His)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
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Format:
Size:
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ALX-201-270-C025
25 µg
170.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
and fused to a His-tag.
CONCENTRATION:
3.2mg/ml
PURITY:
≥99%
FORMULATION:
Liquid. In 50mM TRIS, pH 7.5, containing 2mM EDTA.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40:
F. Pirkl & J. Buchner; J. Mol. Biol.
308
, 795 (2001)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q08752:
Cyclophilin 40 (human)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-201-271
Revised 18-Mar-08
FKBP51 (human) (recombinant) (His)
SYNONYMS
FK506 Binding Protein (51kDa) (human) (recombinant) (His)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-201-271-C025
25 µg
170.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
and fused to a His-tag.
CONCENTRATION:
0.6mg/ml
PURITY:
≥99%
FORMULATION:
Liquid. In 50mM TRIS, pH 7.5, containing 2mM EDTA.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40:
F. Pirkl & J. Buchner; J. Mol. Biol.
308
, 795 (2001)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q13451:
FK506 Binding Protein (51kDa) (human)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-201-272
Revised 18-Mar-08
FKBP52 (human) (recombinant) (His)
SYNONYMS
FK506 Binding Protein (52kDa) (human) (recombinant) (His)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-201-272-C025
25 µg
170.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
and fused to a His-tag.
CONCENTRATION:
1.8mg/ml
PURITY:
≥99%
FORMULATION:
Liquid. In 50mM TRIS, pH 7.5, containing 2mM EDTA.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40:
F. Pirkl & J. Buchner; J. Mol. Biol.
308
, 795 (2001)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q02790:
FK506 Binding Protein (52kDa) (human)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-210-121
Revised 06-Aug-07
Polyclonal Antibody to Cyclophilin 40 (ID)
SYNONYMS
anti-CyP-40 (ID) PAb
anti-Peptidyl-prolyl
cis-trans
Isomerase 40kDa (ID) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-121-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 57-71 (G
57
IGHTTGKPLHFKGC
71
) of human cyclophilin 40.
SPECIFICITY:
Recognizes human and rat cyclophilin 40. Detects a band of ~40kDa by Western blot. Does not cross-react with cyclophilin 18.
APPLICATION:
Western Blot (1:500)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-122
Revised 06-Aug-07
Polyclonal Antibody to Cyclophilin 40
SYNONYMS
anti-CyP-40 PAb
anti-Peptidyl-prolyl
cis-trans
Isomerase 40 kDa PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-122-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human cyclophilin 40.
SPECIFICITY:
Recognizes human, mouse and rat cyclophilin 40. Does not cross-react with cyclophilin 18.
APPLICATION:
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-123
Revised 06-Aug-07
Polyclonal Antibody to Cyclophilin 40 (CT)
SYNONYMS
anti-CyP-40 (CT) PAb
anti-Peptidyl-prolyl
cis-trans
Isomerase 40kDa (CT) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-123-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 356-370 of the C-terminal domain of human cyclophilin 40.
SPECIFICITY:
Recognizes human, mouse and rat cyclophilin 40. Does not cross-react with cyclophilin 18.
APPLICATION:
Flow Cytometry
Gel Supershift Assay
Immunocyctochemistry
Immunohistochemistry (frozen sections)
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-125
Revised 19-Jan-05
Polyclonal Antibody to HSP56
SYNONYMS
anti-Heat Shock Protein 56 PAb
anti-FKBP59 PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-125-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized: Purified antibody.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 441-458 (K
441
DERNDVAGSQSQVETEA
458
) of C-terminal rabbit HSP56 (heat shock protein 56; FKBP59).
SPECIFICITY:
Recognizes human, mouse and rabbit HSP56. Detects a band of ~52-59kDa by Western blot.
APPLICATION:
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-142
Revised 12-Jun-06
Polyclonal Antibody to FKBP12
SYNONYMS
anti-FK506 Binding Protein (12kDa) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-142-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-13 (G
1
VQVETISPGDGR
13
) of human FKBP12 (FK506 binding protein 12kDa).
SPECIFICITY:
Recognizes human, mouse and rat FKBP12. Detects a band of ~12kDa by Western blot.
APPLICATION:
Immunohistochemistry (frozen sections (2µg/ml); paraffin sections)
Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-156-002
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The effects of FK506 on retinal ganglion cells after optic nerve crush:
E.E. Freeman and C.L. Grosskreutz; IOVS
41
, 1111 (2000)
Abstract
Immunophilin expression in the HIV-infected brain:
C.L. Achim, et al.; J. Neuroimmunol.
157
, 126 (2004)
Abstract
Related Products
ALX-156-002
Blocking Peptide for PAb to FKBP12 (Prod. No.
ALX-210-142
)
Further Categories Containing This Product:
Polyclonal Antibodies
•
Mammalian Target of Rapamycin [mTOR] / Related Products
ALX-210-236
Revised 21-May-07
Polyclonal Antibody to FKBP51
SYNONYMS
anti-FK506 Binding Protein (51kDa) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-236-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope affinity-purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 394-407 (C
394
QKKAKEHNERDRR
407
) of human FKBP51 (FK506 binding protein 51).
SPECIFICITY:
Recognizes human, mouse, rat, hamster and dog FKBP51. Detects a band of ~51kDa by Western blot.
APPLICATION:
Western Blot (1:1'000).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-156-003
.
Product Description
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) (Prod. No.
ALX-380-002
)
or FK506 (Prod. No.
ALX-380-008
). Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP’s) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl
cis-trans
-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase’s, immunophilins accelerate folding of some proteins both
in vivo
and in
vitro
by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Prod. No.
ALX-210-236
is a polyclonal antibody that reacts with a ~51kDa protein which is found associated with the progesterone receptor. This protein is also referred to as FKBP54 and FKBP5 in the literature. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-237/1
Revised 28-Nov-08
Polyclonal Antibody to Cyclophilin B
SYNONYMS
anti-CyPB PAb
anti-Peptidyl-prolyl
cis-trans
Isomerase B PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunophilins / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-237/1-C100
100 µg
456.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 194-208 (C
194
GKIEVEKPFAIAKE
208
) of human cyclophilin B.
SPECIFICITY:
Recognizes human, mouse, rat and dog cyclophilin B. Detects a band of ~19kDa by Western blot.
APPLICATION:
Western Blot (0.5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
