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Items 11 of 11
ALX-480-011
Revised 17-Jan-05
Adenosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
Cyclic AMP . Na
cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-011-M100
100 mg
38.00 USD
ALX-480-011-M250
250 mg
70.00 USD
ALX-480-011-G001
1 g
195.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
O
6
P . Na
MW:
328.2 . 23.0
CAS NUMBER:
37839-81-9
MERCK INDEX:
14:
2708
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Key regulator of many cellular reactions. Naturally occurring activator of cAMP-dependent protein kinase (PKA).
Product Specific Literature References
TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes:
J. Lomo, et al.; J. Immunol.
154
, 1634 (1995)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-480-086
Revised 30-Aug-06
Adenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
SYNONYMS
Sp-cAMPS . Na
cAMPS . Na, Sp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-086-M001
1 mg
75.00 USD
ALX-480-086-M005
5 mg
300.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
NaO
5
PS
MW:
367.3
CAS NUMBER:
717794-13-5
PURITY:
≥99% (low adenosine, cAMP and Rp-cAMPS content)
APPEARANCE:
White to off-white lyophilized powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
For application and literature references see the triethylammonium salt (Prod. No.
ALX-480-013
).
Further Categories Containing This Product:
PKA Activators
ALX-480-013
Revised 10-Feb-05
Adenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . triethylammonium salt
SYNONYMS
Sp-cAMPS . TEA
cAMPS . TEA, Sp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-013-M001
1 mg
75.00 USD
ALX-480-013-M005
5 mg
298.00 USD
ALX-480-013-M010
10 mg
580.00 USD
Product Specification
FORMULA:
C
16
H
27
N
6
O
5
PS
MW:
446.5
CAS NUMBER:
93602-66-5
PURITY:
≥99%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). Considerably higher resistance against cyclic nucleotide-dependent phosphodiesterases as compared to N
6
,O
2'
-dibutyryladenosine 3',5'-cyclic monophosphate (dibutyryl-cAMP) (Prod. No.
ALX-480-045
) or 8-bromoadenosine-3',5'-cyclic monophosphate (8-Br-cAMP) (Prod. No.
ALX-480-007
). No metabolic side effects. Membrane permeable in many biological systems.
Product Specific Literature References
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates:
W.R.G. Dostmann, et al.; J. Biol. Chem.
265
, 10484 (1990)
Abstract
;
Full Text
Cyclic AMP antagonist Rp-cAMPS inhibits amylase exocytosis from saponin- permeabilized parotid acini:
T. Takuma & T. Ichida; J. Biochem.
110
, 292 (1991)
Abstract
Second messenger signaling in the regulation of cytosolic pH and DNA synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: role of Na+/H+ exchange:
T. Sugimoto, et al.; J. Cell Physiol.
152
, 28 (1992)
Abstract
The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone:
H. Kaji, et al.; BBRC
182
, 1356 (1992)
Abstract
Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging:
P.J. Sammak, et al.; J. Cell. Biol.
117
, 57 (1992)
Abstract
Effects of activators and inhibitors of protein kinase A on increases in quantal size at the frog neuromuscular junction:
W. Van Der Kloot & D.D. Branisteanu; Pfluegers Arch.
420
, 336 (1992)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-480-007
Revised 16-Feb-05
8-Bromoadenosine-3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
cAMP, 8-Br-, . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-480-007-M010
10 mg
42.00 USD
ALX-480-007-M050
50 mg
125.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
6
P . Na
MW:
407.1 . 23.0
CAS NUMBER:
76939-46-3
PURITY:
≥99% (low in fluorescent and colored impurities)
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). Has increased metabolic stability and membrane permeability compared with cAMP (Prod. No.
ALX-480-011
).
Further Categories Containing This Product:
PKA Activators
ALX-480-025
Revised 26-Jul-06
8-Bromoadenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
SYNONYMS
Sp-8-Br-cAMPS . Na
8-Br-cAMPS . Na, Sp-isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-025-M001
1 mg
140.00 USD
ALX-480-025-M005
5 mg
560.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
5
PS . Na
MW:
423.2 . 23.0
CAS NUMBER:
127634-20-2
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or aqueous buffer.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Metabolically resistant activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). No metabolic side effects as observed with dibutyryl-cAMP (N
6
,O
2'
-Dibutyryladenosine 3',5'-cyclic monophosphate, Prod. No.
ALX-480-045
) or 8-Br-cAMP (8-Bromoadenosine-3',5'-cyclic monophosphate, Prod. No.
ALX-480-007
). Significantly more lipophilic and membrane permeant as compared to Sp-cAMPS (Adenosine 3',5'-cyclic monophosphothioate, Sp isomer, Prod. No.
ALX-480-013
).
Product Specific Literature References
Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium:
P. Schaap, et al.; J. Biol. Chem.
268
, 6323 (1993)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Activators
ALX-480-027
Revised 25-Jun-08
8-Bromoguanosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt (high purity)
SYNONYMS
Sp-8-Br-cGMPS . Na
8-Br-cGMPS . Na, Sp-isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-480-027-M001
1 mg
80.00 USD
ALX-480-027-M005
5 mg
320.00 USD
Product Specification
FORMULA:
C
10
H
10
BrN
5
O
6
PS . Na
MW:
439.2 . 23.0
CAS NUMBER:
153660-03-8
PURITY:
≥99% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
IDENTITY:
Identity determined by MS,
1
H-NMR and UV.
Product Description
Unspecific activator of both cGMP-dependent protein kinase (PKG) 1α and cAMP-dependent protein kinase (PKA). Resistant to cyclic nucleotide phosphodiesterases. Much more lipophilic and membrane permeant as compared to cyclic GMP (Prod. No.
ALX-480-059
) or Sp-cGMPS (Prod. No.
ALX-480-073
).
Product Specific Literature References
Evidence for two intracellular calcium pools in Dictyostelium: the cAMP- induced calcium influx is directed into a NBD-Cl- and 2,5-di-(tert- butyl)1,4-hydroquinone-sensitive pool:
H. Flaadt, et al.; J. Cell Sci.
105
, 1131 (1993)
Abstract
Further Categories Containing This Product:
PKA Activators
•
PKG Activators
ALX-480-030
Revised 07-Jun-06
8-(4-Chlorophenylthio)adenosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
8-pCPT-cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-030-M010
10 mg
25.00 USD
ALX-480-030-M025
25 mg
50.00 USD
Product Specification
FORMULA:
C
16
H
14
ClN
5
O
6
PS . Na
MW:
470.8 . 23.0
CAS NUMBER:
93882-12-3
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
Product Description
Lipophilic, membrane permeable activator of both cAMP- and cGMP-dependent protein kinases (PKA, PKG). More potent than cAMP and more resistant to phosphodiesterases, with good selectivity for site B of PKA. For specific activation of the cAMP pathway the highly membrane permeable Sp-5,6-DCl-cBIMPS (Prod. No.
ALX-480-047
) is a recommended.
Product Specific Literature References
cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor:
R.E. Rydel & L.A. Greene; PNAS
85
, 1257 (1988)
Abstract
Comparison of the two classes of binding sites (A and B) of type I and type II cyclic-AMP-dependent protein kinases by using cyclic nucleotide analogs:
D. Ogreid, et al.; Eur. J. Biochem.
181
, 19 (1989)
Abstract
8-(4-Chlorophenyl)thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA):
B.J. Connolly, et al.; Biochem. Pharmacol.
44
, 2303 (1992)
Abstract
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets:
J. Geiger, et al.; PNAS
89
, 1031 (1992)
Abstract
The role of protein kinase A anchoring via the RII alpha regulatory subunit in the murine immune system:
R.V. Schillace, et al.; J. Immunol.
174
, 6847 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
PKG Activators
•
PKA Activators
ALX-480-070
Revised 05-Dec-04
8-(4-Chlorophenylthio)guanosine-3',5'-cyclic-Monophosphothioate, Sp-Isomer . sodium salt
SYNONYMS
Sp-8-pCPT-cGMPS . Na
8-pCPT-cGMPS . Na, Sp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cGMP Derivatives
Ordering Information
Product Numbers:
Format:
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ALX-480-070-MC05
0.5 mg
80.00 USD
ALX-480-070-M001
1 mg
140.00 USD
Product Specification
FORMULA:
C
16
H
14
N
5
ClO
6
S
2
P . Na
MW:
502.9 . 23.0
CAS NUMBER:
160385-87-5
PURITY:
≥99%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Potent activator of both cGMP-dependent protein kinase 1α, 1β and type II and cAMP-dependent protein kinase II. Excellent cell membrane permeability and phosphodiesterase stability.
Product Specific Literature References
(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor:
E. Butt, et al.; Eur. J. Pharmacol.
269
, 265 (1994)
Abstract
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms:
D.M. Gamm, et al.; J. Biol. Chem.
270
, 27380 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
PKG Activators
•
PKA Activators
ALX-480-093
Revised 07-Feb-08
8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
8-CPT-2'-O-Me-cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-093-M001
1 mg
130.00 USD
ALX-480-093-M005
5 mg
520.00 USD
Product Specification
FORMULA:
C
17
H
16
ClN
5
O
6
PS . Na
MW:
484.8 . 23.0
CAS NUMBER:
510774-50-2
PURITY:
≥98% (HPLC)
PURITY DETAIL:
Product is not sterile.
FORMULATION:
White to off-white powder.
SOLUBILITY:
Soluble in water, aqueous buffers, DMSO, dimethyl formamide or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Hygroscopic.
IDENTITY:
Determined by
1
H-NMR, MS and UV (λ
max
: 282nm, ε: 16’000, pH 7).
Product Description
Specific, potent and membrane permeant activator of the Epac cAMP receptor. Activates Epac1 and Epac2, the guanine nucleotide-exchange factors (GEFs) for the small GTPases Rap1 and Rap2. Does not activate protein kinase A (PKA), neither
in vitro
nor
in vivo
and is therefore a valuable tool to specifically discriminate between PKA- and Epac-mediated effects. Since a free 2'-ribose hydroxyl group in cyclic AMP is essential for stimulation of PKA, the methylated structure of 8-CPT-2'-O-Me-cAMP is an extremely poor PKA activator. Its high lipophilicity allows for good membrane permeability in most biosystems and its increased resistance towards phosphodiesterases prevents rapid hydrolysis.
Product Specific Literature References
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
:
J.M. Enserink, et al.; Nat. Cell Biol.
4
, 901 (2002)
Abstract
;
Full Text
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells
:
G. Kang, et al.; J. Biol. Chem.
278
, 8279 (2003)
Abstract
;
Full Text
Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the {beta}2-adrenergic receptor
:
S. Rangarajan, et al.; J. Cell Biol.
160
, 487 (2003)
Abstract
General Literature References
Signal transduction. New exchange, new target
:
J. Downward; Nature
396
, 416 (1998), Comment
Abstract
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
:
J. de Rooij, et al.; Nature
396
, 474 (1998)
Abstract
A family of cAMP-binding proteins that directly activate Rap1
:
H. Kawasaki, et al.; Science
282
, 2275 (1998)
Abstract
Further Categories Containing This Product:
PKA Activators
•
Guanine-nucleotide Exchange Factors [GEFs]
ALX-480-045
Revised 23-Jan-08
N6,O2’-Dibutyryladenosine 3’,5’-cyclic Monophosphate . sodium salt
SYNONYMS
Dibutyryl-cAMP . Na
cAMP, DB-, . Na
Bucladesine . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-480-045-M005
5 mg
25.00 USD
ALX-480-045-M025
25 mg
75.00 USD
Product Specification
FORMULA:
C
18
H
23
N
5
O
8
P . Na
MW:
468.4 . 23.0
CAS NUMBER:
16980-89-5
PURITY:
≥97%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water (200mM), DMSO (200mM) or 96% ethanol (25mM).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Solutions must be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.
