Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
>
Signal Transduction
>
Lipid Signalling Pathways
>
Phospholipase A2 [PLA2] / Related Products
> PLA2 Inhibitors
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
1-20
of 21
Page 1
of 2
Select Page:
1
2
>>
ALX-270-047
Revised 26-Sep-07
Aristolochic acid
SYNONYMS
8-Methoxy-6-nitrophenanthrol(3,4-d)-1,3-dioxide-5-carboxylic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-047-M025
25 mg
25.00 USD
ALX-270-047-M100
100 mg
90.00 USD
Product Specification
FORMULA:
C
17
H
11
NO
7
MW:
341.3
CAS NUMBER:
313-67-7
MERCK INDEX:
14:
786
RTECS:
CF3325000
SOURCE/HOST:
Isolated from
Aristolochia clematis
.
PURITY:
≥97% (~1:1 mixture of aristolochic acids I (A) and II (B))
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
MAY BE CARCINOGENIC. TOXIC. MAY BE MUTAGENIC.
Product Description
Phospholipase A
2
(PLA
2
) inhibitor active against the enzymes found in many snake venoms as well as those of human platelets and synovial fluids. Inhibits ionophore-stimulated PLA
2
activity in human neutrophils. Has been shown to be nephropathic and carcinogenic.
Product Specific Literature References
Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid:
B.S. Vishwanath, et al.; Toxicon
25
, 501 (1987)
Abstract
Interaction of aristolochic acid with Vipera russelli phospholipase A2: its effect on enzymatic and pathological activities:
B.S. Vishwanath & T.V. Gowda; Toxicon
25
, 929 (1987)
Abstract
Interaction of phospholipase A2 from Vipera russelli venom with aristolochic acid: a circular dichroism study:
B.S. Vishwanath, et al.; Toxicon
25
, 939 (1987)
Abstract
Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid:
B.S. Vishwanath, et al.; Inflammation
12
, 549 (1988)
Abstract
Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils:
M.D. Rosenthal, et al.; Biochim. Biophys. Acta
1001
, 3 (1989)
Abstract
Suramin alters phosphoinositide synthesis and inhibits growth factor receptor binding in HT-29 cells:
R. Kopp & A. Pfeiffer; Cancer Res.
50
, 6490 (1990)
Abstract
The effects of the phospholipase A2 inhibitors aristolochic acid and PGBx on A23187-stimulated mobilization of arachidonate in human neutrophils are overcome by diacylglycerol or phorbol ester:
M.D. Rosenthal, et al.; Biochim. Biophys. Acta
1126
, 319 (1992)
Abstract
Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils:
J.D. Winkler, et al.; Biochem. Pharmacol.
44
, 2055 (1992)
Abstract
Selective inhibition of group II phospholipase A2 by quercetin:
M. Lindahl & C. Tagesson; Inflammation
17
, 573 (1993)
Abstract
Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy:
H.H. Schmeiser, et al.; Cancer Res.
56
, 2025 (1996)
Abstract
Aristolochic acid and ’Chinese herbs nephropathy’: a review of the evidence to date:
J.P. Cosyns; Drug Saf.
26
, 33 (2003), Review
Abstract
Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells:
Y.H. Hsin, et al.; Apoptosis
11
, 2167 (2006)
Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Natural Products - Other Tumor Promoters
•
PLA2 Inhibitors
•
Alkaloids
•
Other Toxins
ALX-270-105
Revised 05-Dec-04
OBAA
SYNONYMS
3-(4-Octadecyl)-benzoylacrylic acid
4-(4-Octadecylphenyl)-4-oxobutenoic acid
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PLA2 Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-105-M005
5 mg
35.00 USD
Product Specification
FORMULA:
C
28
H
44
O
3
MW:
428.6
CAS NUMBER:
134531-42-3
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Potent inhibitor of phospholipase A
2
.
Product Specific Literature References
Phospholipase A2 inhibition by alkylbenzoylacrylic acids:
T. Köhler, et al.; Agents Actions
32
, 70 (1991)
Abstract
Allergen-induced bronchospasm in passively sensitized guinea pigs: influence of new substances in comparison to reference compounds:
S. Madi, et al.; Agents Actions
32
, 144 (1991)
Abstract
Phospholipase A2 inhibition by alkylbenzoylacrylic acids:
T. Köhler, et al.; Biochem. Pharmacol.
44
, 805 (1992)
Abstract
ALX-270-115
Revised 08-Dec-05
ONO-RS-082
SYNONYMS
2-(p-Amylcinnamoyl)amino-4-chlorobenzoic acid
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PLA2 Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-115-M005
5 mg
40.00 USD
ALX-270-115-M025
25 mg
120.00 USD
Product Specification
FORMULA:
C
21
H
22
ClNO
3
MW:
371.9
CAS NUMBER:
99754-06-0
PURITY:
≥98%
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
USE/STABILITY:
Solutions are stable for 3 months when stored at -20°C.
HANDLING:
Do not freeze. Protect from light.
Product Description
Phospholipase A
2
inhibitor. Inhibits epinephrine-stimulated thromboxane production in human platelets. Also blocks insulin secretion in pancreatic islets in response to glucose.
Product Specific Literature References
Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine:
H.S. Banga, et al.; PNAS
83
, 9197 (1986)
Abstract
Inhibition of phospholipase A2 and insulin secretion in pancreatic islets:
R.J. Konrad, et al.; Biochim. Biophys. Acta
1135
, 215 (1992)
Abstract
ALX-270-171
Revised 30-Jun-08
Chlorpromazine . hydrochloride
SYNONYMS
2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-171-G001
1 g
22.00 USD
ALX-270-171-G005
5 g
66.00 USD
Product Specification
FORMULA:
C
17
H
19
ClN
2
S . HCl
MW:
318.9 . 36.5
CAS NUMBER:
69-09-0
MERCK INDEX:
14:
2185
RTECS:
SO1750000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D
2
antagonist. H
1
antagonist. Inhibits TNF-α production. Potent PLA
2
inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity:
H.B. Collier; Clin. Biochem.
7
, 331 (1974)
Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins:
D.R. Marshak, et al.; Biochemistry
24
, 144 (1985)
Abstract
Selective inhibition of group II phospholipase A2 by quercetin:
M. Lindahl & C. Tagesson; Inflammation
17
, 573 (1993)
Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge:
M. Palacios, et al.; BBRC
196
, 280 (1993)
Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice:
H. Yamamoto; Toxicol. Lett.
66
, 73 (1993)
Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice:
M.G. Netea, et al.; J. Infect. Dis.
171
, 393 (1995)
Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase:
A. Boveris, et al.; Methods Enzymol.
359
, 328 (2002)
Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine:
S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys.
430
, 170 (2004)
Abstract
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products
•
Phosphodiesterases / Related Products
•
Chemopreventive Agents Other Products
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
PLA2 Inhibitors
•
Dopaminergics & Dopamine Receptors / Related Products
ALX-270-195
Revised 14-Jan-08
Bromoenol lactone
SYNONYMS
BEL
(
E
)-6-(Bromomethylene)tetrahydro-3-(1-naphthalenyl)-2
H
-pyran-2-one
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PLA2 Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-195-M005
5 mg
136.00 USD
Product Specification
FORMULA:
C
16
H
13
BrO
2
MW:
317.2
CAS NUMBER:
88070-98-8
PURITY:
98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, acetonitrile, DMSO or dimethyl formamide.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Before use, product should be dissolved in an organic solvent miscible with water. Further dilutions in aqueous buffers should be made just prior to performing experiment. Store aqueous solutions on ice and use within 12 hours. Although the aqueous solutions may be stable for more than 12 hours, we strongly recommend using a fresh preparation each day.
HAZARD:
IRRITANT.
Product Description
Potent, irreversible inhibitor of Ca
2+
-independent phospholipase A
2
(iPLA
2
). Also inhibits the macrophage PLA
2
in a concentration-dependent manner. Effective enzyme-activated irreversible inhibitor of chymotrypsin.
Product Specific Literature References
Haloenol lactones. Potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin
:
S.B. Daniels, et al.; J. Biol. Chem.
258
, 15046 (1983)
Abstract
;
Full Text
Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism-based discrimination between calcium- dependent and -independent phospholipases A2:
S.L. Hazen, et al.; J. Biol. Chem.
266
, 7227 (1991)
Abstract
;
Full Text
Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones:
E.J. Ackermann, et al.; J. Biol. Chem.
270
, 445 (1995)
Abstract
;
Full Text
Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages:
J. Balsinde, et al.; PNAS
92
, 8527 (1995)
Abstract
ALX-300-142
Revised 09-Dec-04
Thioetheramide PC
SYNONYMS
1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-
sn
-glycero-3-phosphocholine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-300-142-M005
5 mg
101.00 USD
ALX-300-142-M010
10 mg
177.00 USD
Product Specification
FORMULA:
C
40
H
83
N
2
O
5
PS
MW:
735.1
CAS NUMBER:
116457-99-9
PURITY:
≥98%
APPEARANCE:
Lyophilized powder.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from moisture.
Product Description
Inhibitor of snake venom phospholipase A
2
(PLA
2
).
Product Specific Literature References
The interaction of phospholipase A2 with phospholipid analogues and inhibitors:
L. Yu, et al.; J. Biol. Chem.
265
, 2657 (1990)
Abstract
;
Full Text
Further Categories Containing This Product:
PLA2 Inhibitors
ALX-300-145
Revised 18-Dec-07
MJ33
SYNONYMS
1-Hexadecyl-3-(trifluoroethyl)-
sn
-glycero-2-phosphomethanol . Li
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-300-145-M005
5 mg
95.00 USD
Product Specification
FORMULA:
C
22
H
43
F
3
O
6
P . Li
MW:
491.6 . 6.9
PURITY:
≥93%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Active site-directed, specific, competitive, and reversible inhibitor of phospholipase A
2
(PLA
2
). Shows high specificity for type I (pancreatic) and bee venom PLA
2
, but has relatively poor affinity for type II human synovial PLA
2
.
Product Specific Literature References
Active-site-directed specific competitive inhibitors of phospholipase A2: novel transition state analogues:
M.K. Jain, et al.; Biochemistry
30
, 10256 (1991)
Abstract
A competitive inhibitor of phospholipase A2 decreases surfactant phosphatidylcholine degradation by the rat lung:
A.B. Fisher, et al.; Biochem. J.
288
, 407 (1992)
Abstract
Inhibition of lung calcium-independent phospholipase A2 by surfactant protein A:
A.B. Fisher, et al.; Am. J. Physiol.
267
, L335 (1994)
Abstract
Purification and characterization of a calcium-independent acidic acid phospholipase A2 from rat lung:
R. Wang, et al.; Biochem. J.
304
, 131 (1994)
Abstract
Role of acidic Ca2+-independent phospholipase A2 in synthesis of lung dipalmitoyl phosphatidylcholine:
A.B. Fisher, et al.; Am. J. Physiol.
272
, L238 (1997)
Abstract
Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein:
T.S. Kim, et al.; J. Biol. Chem.
272
, 2542 (1997)
Abstract
;
Full Text
Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol:
K. Sekar, et al.; Biochemistry
36
, 14186 (1997)
Abstract
Cloning and expression of rat lung acidic Ca2+-independent PLA2 and its organ distribution:
T.S. Kim, et al.; Am. J. Physiol.
274
, L750 (1998)
Abstract
Role of phospholipase A2 (group I secreted) in the genesis of basal tone in the internal anal sphincter smooth muscle:
M.A. de Godoy & S. Rattan; Am. J. Physiol. Gastrointest. Liver. Physiol.
293
, G979 (2007)
Abstract
Further Categories Containing This Product:
PLA2 Inhibitors
ALX-306-008
Revised 07-Feb-05
D-erythro-Sphingosine, Dihydro-
SYNONYMS
D-
erythro
-Dihydrosphingosine
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Ceramides / Cerebrosides / Sphingolipids / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-306-008-M010
10 mg
70.00 USD
Product Specification
FORMULA:
C
18
H
39
NO
2
MW:
301.5
CAS NUMBER:
3102-56-5
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of protein kinase C (PKC). Blocks phospholipases A
2
(PLA2) and the D-sphingosine precursor.
Product Specific Literature References
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds:
A.H. Merrill, Jr., et al.; Biochemistry
28
, 3138 (1989)
Abstract
Sphingolipid metabolism and signal transduction: inhibition of in vitro phospholipase activity by sphingosine:
R.C. Franson, et al.; Biochim. Biophys. Acta
1136
, 169 (1992)
Abstract
Glucocorticoid stimulation of amnion cell prostaglandin synthesis: suppression by protein kinase C inhibitors and independence of phorbol ester-sensitive protein kinase C:
T. Zakar, et al.; Biochim. Biophys. Acta
1136
, 161 (1992)
Abstract
Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60):
B.Y. Yung, et al.; BBRC
199
, 888 (1994)
Abstract
Further Categories Containing This Product:
PKC Inhibitors
•
PLA2 Inhibitors
ALX-340-001
Revised 28-Jul-06
Arachidonyl trifluoromethylketone
SYNONYMS
AACOCF
3
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PLA2 Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-001-M005
5 mg
70.00 USD
ALX-340-001-M010
10 mg
110.00 USD
ALX-340-001-M050
50 mg
390.00 USD
Product Specification
FORMULA:
C
21
H
31
F
3
O
MW:
356.5
CAS NUMBER:
149301-79-1
PURITY:
≥98%
APPEARANCE:
Clear to yellow oil.
SOLUBILITY:
25mg/ml soluble in 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Dissolve in solvent purged with nitrogen or argon. Store under nitrogen or argon in tightly sealed container. Solutions are stable for up to 1 month when stored under nitrogen or argon in tightly sealed container at -80°C.
HANDLING:
PROTECT FROM AIR!
HAZARD:
TOXIC.
Product Description
Selective inhibitor of both, Ca
2+-
dependent and Ca
2+
-independent phospholipase A
2
(PLA
2
), but not secretory PLA
2
(sPLA
2
). Also inhibits fatty acid amide hydrolase (FAAH) and anandamide amidase.
Product Specific Literature References
Inhibitors of arachidonoyl ethanolamide hydrolysis:
B. Koutek, et al.; J. Biol. Chem.
269
, 22937 (1994)
Abstract
;
Full Text
Further Categories Containing This Product:
Fatty Acid Amide Hydrolase [FAAH] / Related Products
ALX-340-008
Revised 22-May-07
7,7-Dimethyleicosadienoic acid
SYNONYMS
DEDA
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PLA2 Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-340-0
