ALEXIS Biochemicals: Caveolin-1 Scaffolding Domain Peptide

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ALX-105-001

Revised 06-Jun-06

NG-Nitro-L-arginine
SYNONYMS	L-NOARG L-Nitroarginine
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-105-001-G005		5 g	22.00 USD
ALX-105-001-G025		25 g	63.00 USD

Product Specification

FORMULA:	C₆H₁₃N₅O₄
MW:	219.2
CAS NUMBER:	2149-70-4
PURITY:	≥99%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 0.1N HCl. Moderately soluble in water; insoluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Inhibitor of nitric oxide synthase (NOS).

Product Specific Literature References

L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle: A. Gibson, et al.; Br. J. Pharmacol. 99, 602 (1990) Abstract
N omega-nitro-L-arginine: a potent inhibitor of endothelium-derived relaxing factor formation: K. Ishii, et al.; Eur. J. Pharmacol. 176, 219 (1990) Abstract
L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro: P.K. Moore, et al.; Br. J. Pharmacol. 99, 408 (1990) Abstract
Inhibitory effects of L-NG-nitro-arginine on the synthesis of EDRF and the cerebroarterial response to vasodilator nerve stimulation: N. Toda, et al.; Life. Sci. 47, 345 (1990) Abstract
The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle: S.R. Brave, et al.; BBRC 179, 1017 (1991) Abstract
Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo: M.A. Dwyer, et al.; BBRC 176, 1136 (1991) Abstract
On the substrate specificity of nitric oxide synthase: M. Hecker, et al.; FEBS Lett. 294, 221 (1991) Abstract
Enhanced photorelaxation in aorta, pulmonary artery and corpus cavernosum produced by BAY K 8644 or N-nitro-L-arginine: X. Chen and C.N. Gillis; BBRC 186, 1522 (1992) Abstract
Possible involvement of nitric oxide in chlordiazepoxide-induced anxiolysis in mice: R.M. Quock and E. Nguyen; Life Sci. 51, PL255 (1992) Abstract
The role of nitric oxide in mediating non-adrenergic non-cholinergic relaxation in longitudinal muscle of human taenia coli: F.S.-F. Tam & K. Hillier; Life Sci 51, 1277 (1992) Abstract
NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta: K.C. Chang, et al.; BBRC 191, 509 (1993) Abstract
Selective inhibition of constitutive nitric oxide synthase by L-NG- nitroarginine: E.S. Furfine, et al.; Biochemistry 32, 8512 (1993) Abstract
Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor: Y.A. Kolesnikov, et al.; PNAS 90, 5162 (1993) Abstract
Reversible inactivation of endothelial nitric oxide synthase by NG- nitro-L-arginine: B. Mayer, et al.; FEBS Lett. 333, 203 (1993) Abstract

ALX-105-002

Revised 12-Nov-07

NG-Nitro-D-arginine
SYNONYMS	D-NOARG D-Nitroarginine
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-105-002-M250		250 mg	22.00 USD
ALX-105-002-G001		1 g	53.00 USD

Product Specification

FORMULA:	C₆H₁₃N₅O₄
MW:	219.2
CAS NUMBER:	66036-77-9
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 0.1M HCl. Moderately soluble in water; insoluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

ALX-105-003

Revised 02-Dec-05

L-NAME . hydrochloride
SYNONYMS	N^G-Nitro-L-arginine-methyl ester . HCl
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-105-003-G005		5 g	32.00 USD
ALX-105-003-G025		25 g	133.00 USD

Product Specification

FORMULA:	C₇H₁₅N₅O₄ . HCl
MW:	233.2 . 36.5
CAS NUMBER:	51298-62-5
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inhibitor of nitric oxide synthase (NOS). More soluble than N^G-Nitro-L-arginine (Prod. No. ALX-105-001). Suppresses the release of nitric oxide (NO) from endothelial cells. Has a different effect on the superoxide generation by NOS than L-NMMA (Prod. No. ALX-106-001).

Product Specific Literature References

L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro: P.K. Moore, et al.; Br. J. Pharmacol. 99, 408 (1990) Abstract
Generation of superoxide by purified brain nitric oxide synthase: S. Pou, et al.; J. Biol. Chem. 267, 24173 (1992) Abstract; Full Text

ALX-105-004

Revised 02-Dec-05

D-NAME . hydrochloride
SYNONYMS	N^G-Nitro-D-arginine-methyl ester . HCI
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-105-004-M250		250 mg	32.00 USD

Product Specification

FORMULA:	C₇H₁₅N₅O₄ . HCl
MW:	233.2 . 36.5
CAS NUMBER:	50912-92-0
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in methanol or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inactive isomer of L-NAME (Prod. No. ALX-105-003).

ALX-105-009

Revised 06-Jun-06

N-Methyl-D-aspartic acid
SYNONYMS	NMDA
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-105-009-M010		10 mg	23.00 USD
ALX-105-009-M050		50 mg	60.00 USD

Product Specification

FORMULA:	C₅H₉NO₄
MW:	147.1
CAS NUMBER:	6384-92-5
MERCK INDEX:	14: 6662
RTECS:	CI9457000
PURITY:	≥98%
APPEARANCE:	White crystalline powder.
SOLUBILITY:	Soluble in dilute aqueous base; slightly soluble in water or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.

Product Description

Selective ionotropic NMDA receptor agonist.

Product Specific Literature References

Excitatory amino acid transmitters: J.C. Watkins & R.H. Evans; Ann. Rev. Pharmacol. Toxicol. 21, 165 (1981), (Review) Abstract
NMDA receptors and ligands in the vertebrate CNS: T.W. Stone & N.R. Burton; Progr. Neurobiol. 30, 333 (1988), (Review) Abstract

Further Categories Containing This Product:

Special Amino Acids • NMDA Receptors / Related Products

ALX-105-010

Revised 04-Dec-04

N-Methyl-L-aspartic acid
SYNONYMS	NMLA
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-105-010-M010		10 mg	20.00 USD
ALX-105-010-M050		50 mg	50.00 USD

Product Specification

FORMULA:	C₅H₉NO₄
MW:	147.1
CAS NUMBER:	4226-18-0
PURITY:	≥98%
APPEARANCE:	White crystalline powder.
SOLUBILITY:	Soluble in dilute aqueous base.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.

Further Categories Containing This Product:

Special Amino Acids

ALX-106-001

Revised 30-Nov-06

L-NMMA . monoacetate
SYNONYMS	N^G-Monomethyl-L-arginine . monoacetate
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-106-001-M005		5 mg	20.00 USD
ALX-106-001-M025		25 mg	55.00 USD
ALX-106-001-M100		100 mg	180.00 USD
ALX-106-001-G001		1 g	360.00 USD

Product Specification

FORMULA:	C₇H₁₆N₄O₂ . CH₃COOH
MW:	188.2 . 60.1
CAS NUMBER:	53308-83-1
PURITY:	≥99%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Standard inhibitor of nitric oxide synthase. Suppresses the release of nitric oxide from endothelial cells.

Product Specific Literature References

Identification of arginine as a precursor of endothelium-derived relaxing factor: I. Sakuma, et al.; PNAS 85, 8664 (1988) Abstract
A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation: D.D. Rees, et al.; Br. J. Pharmacol. 96, 418 (1989) Abstract
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase: M. Palacios-Callender, et al.; PNAS 101, 7630 (2004) Abstract; Full Text

Further Categories Containing This Product:

PRMTs, Mono- & Dimethylarginine / Related Products

ALX-106-002

Revised 03-Jun-03

D-NMMA . monoacetate
SYNONYMS	N^G-Monomethyl-D-arginine . monoacetate
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-106-002-M005		5 mg	27.00 USD
ALX-106-002-M025		25 mg	100.00 USD
ALX-106-002-M100		100 mg	280.00 USD

Product Specification

FORMULA:	C₇H₁₆N₄O₂ . CH₃COOH
MW:	188.2 . 60.1
CAS NUMBER:	137694-75-8
PURITY:	≥99%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Further Categories Containing This Product:

PRMTs, Mono- & Dimethylarginine / Related Products

ALX-106-003

Revised 16-Dec-08

L-Citrulline
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-106-003-G005		5 g	20.00 USD

Product Specification

FORMULA:	C₆H₁₃N₃O₃
MW:	175.2
CAS NUMBER:	372-75-8
MERCK INDEX:	14: 2331
PURITY:	≥98% (TLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water or 1M HCl.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Essential intermediate in the biosynthesis of nitric oxide from L-arginine.

Product Specific Literature References

A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells: R.M.J. Palmer and S. Moncada; BBRC 158, 348 (1989) Abstract
The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine: M. Hecker, et al.; PNAS 87, 8612 (1990) Abstract
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine: D.J. Stuehr, et al.; J. Biol. Chem. 266, 6259 (1991) Abstract; Full Text

ALX-106-005

Revised 24-Feb-05

NG, NG-Dimethyl-L-arginine . di(p-hydroxyazobenzene-p'-sulfonate)
SYNONYMS	ADMA . 2HABS H-Arg(di-Me)-OH . 2HABS (asymmetrical)
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-106-005-M005		5 mg	23.00 USD
ALX-106-005-M025		25 mg	55.00 USD

Product Specification

FORMULA:	C₈H₁₈N₄O₂ . 2C₁₂H₁₀N₂O₄S
MW:	202.2 . 556.6
PURITY:	≥97%
APPEARANCE:	Orange powder.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Inhibits nitric oxide synthesis. This salt form is more stable than the dihydrochloride.

Product Specific Literature References

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells: J.B. Hibbs Jr., et al.; J. Immunol. 138, 550 (1987) Abstract
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure: P. Vallance, et al.; Lancet 339, 572 (1992), and references cited therein. Abstract

Further Categories Containing This Product:

PRMTs, Mono- & Dimethylarginine / Related Products

ALX-106-006

Revised 15-Oct-07

NG, NG-Dimethyl-L-arginine . dihydrochloride
SYNONYMS	H-Arg(di-Me)-OH . 2HCl (asymmetrical) ADMA . 2HCl
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-106-006-M005		5 mg	33.00 USD
ALX-106-006-M025		25 mg	85.00 USD