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ALX-522-092
Revised 27-Mar-06
MegaAPRIL™, Soluble (mouse) (H98) (recombinant)
SYNONYMS
rms
Mega
APRIL™ (H98)
APRIL, Soluble (mouse) (recombinant):ACRP30
headless
(mouse) (H98)
A-Proliferation-inducing Ligand (mouse) (recombinant):ACRP30
headless
(mouse) (H98)
TNFSF 13, Soluble (mouse) (recombinant):ACRP30
headless
(mouse) (H98)
CD256, Soluble (mouse) (recombinant):ACRP30
headless
(mouse) (H98)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
APRIL
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-092-3010
3x10 µg
440.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
Produced in HEK 293 cells. The extracellular domain of mouse APRIL (aa 98-232) is fused at the N-terminus to a mouse ACPR30
headless
(aa 18-110) and a FLAG
®
-tag.
CONCENTRATION:
0.1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
≤0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY:
Binds to human and mouse BCMA and TACI. Does not bind to proteoglycans.
BIOLOGICAL ACTIVITY:
Stimulates B cell proliferation.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth:
M. Hahne, et al.; J. Exp. Med.
188
, 1185 (1998)
Abstract
Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI:
S.A. Marsters, et al.; Curr. Biol.
10
, 785 (2000)
Abstract
A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth:
P. Rennert, et al.; J. Exp. Med.
192
, 1677 (2000)
Abstract
Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS:
Y. Wu, et al.; J. Biol. Chem.
275
, 35478 (2000)
Abstract
;
Full Text
APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity:
G. Yu, et al.; Nat. Immunol.
1
, 252 (2000)
Abstract
Identification of proteoglycans as the APRIL-specific binding partners:
K. Ingold, et al.; J. Exp. Med.
201
, 1375 (2005)
Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-804-144
Revised 07-Nov-05
Monoclonal Antibody to ACRP30headless (human) (Ne.Na)
SYNONYMS
anti-ACRP30
headless
(human) MAb (Ne.Na)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-144-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
Ne.Na
ISOTYPE:
Mouse IgG1
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE).
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human ACRP30
headless
(tail adiponectin) (Prod. No.
ALX-203-002
).
SPECIFICITY:
Recognizes human ACRP30
headless
. Does not cross-react with mouse ACRP30
headless.
Does not cross-react with full length adiponectin.
APPLICATION:
ELISA (capture)
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-515
Revised 01-Oct-08
Monoclonal Antibody to Adiponectin (rat) (RADI 06)
SYNONYMS
anti-ACRP30 (rat) MAb (RADI 06)
anti-Adipocyte Complement Related Protein of 30kDa (rat) MAb (RADI 06)
anti-AdipoQ (rat) MAb (RADI 06)
anti-apM1 (rat) MAb (RADI 06)
anti-GBP28 (rat) MAb (RADI 06)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-515-C050
50 µg
195.00 USD
ALX-804-515-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
CLONE:
RADI 06
ISOTYPE:
Mouse IgG2
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant rat adiponectin.
SPECIFICITY:
Recognizes both natural and recombinant rat adiponectin. Does not cross-react with human and mouse adiponectin. Detects a band of ~30kDa by Western blot.
APPLICATION:
ELISA (direct and indirect: 1:5’000-1:10’000).
Western Blot (1:2’000-10’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature.)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Western Blot Protocol:
1: SDS-PAGE Sample buffer
62.5mM Tris-HCl (pH 6.8), 2% SDS, 10% glycerol, 5% β-mercaptoethanol, 0.1% (w/v) bromophenol blue.
2: Serum preparation
A. 1µl rat serum and 9µl sample buffer after boiling for 5 min.
B. Recombinant rat adiponectin protein: 100ng/µl and 9µl sample buffer after boiling for 5 min.
3: Electrophoresis
4: Transfer
A. Nitrocellulose membrane
B. Constant 30V for 16 hours.
5: Western blotting
A. Blocking: 0.5% skim milk in TBST
B. Secondary IgG: anti-mouse IgG whole molecular (1:5’000)
C. ECL reaction
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-453
Revised 15-Nov-07
Monoclonal Antibody to Adiponectin (human) (HADI 741)
SYNONYMS
anti-ACRP30 (human) MAb (HADI 741)
anti-Adipocyte Complement Related Protein of 30kDa (human) MAb (HADI 741)
anti-AdipoQ (human) MAb (HADI 741)
anti-apM1 (human) MAb (HADI 741)
anti-GBP28 (human) MAb (HADI 741)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-453-C050
50 µg
195.00 USD
ALX-804-453-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
HADI 741
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1
mg/ml
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human adiponectin.
SPECIFICITY:
Recognizes the C-terminal globular domain of both natural and recombinant human adiponectin. Cross-reactivity with other species not tested.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:10’000)
Western Blot
(1:2’000-1:10’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus
:
B.S. Youn, et al.; J. Clin. Endocrinol. Metab.
89
, 150 (2004)
Abstract
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-452
Revised 24-Oct-05
Monoclonal Antibody to Adiponectin (human) (HADI 773)
SYNONYMS
anti-ACRP30 (human) MAb (HADI 773)
anti-Adipocyte Complement Related Protein of 30kDa (human) MAb (HADI 773)
anti-AdipoQ (human) MAb (HADI 773)
anti-apM1 (human) MAb (HADI 773)
anti-GBP28 (human) MAb (HADI 773)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-452-C050
50 µg
195.00 USD
ALX-804-452-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
HADI 773
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human adiponectin.
SPECIFICITY:
Recognizes both natural and recombinant human adiponectin. Cross-reactivity with other species not tested.
APPLICATION:
ELISA
(direct and indirect: 1:5'000-1:10'000).
Immunohistochemistry
(paraffin sections: 1:500 in TBS/Triton for 30 min. at room temperature).
Western Blot
(1:5'000-1:10'000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus
:
B.S. Youn, et al.; J. Clin. Endocrinol. Metab.
89
, 150 (2004)
Abstract
Adiponectin expression in human fetal tissues during mid- and late gestation
:
S. Corbetta, et al.; J. Clin. Endocrinol. Metab.
90
, 2397 (2005)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-513
Revised 13-Aug-08
Monoclonal Antibody to Adiponectin (mouse) (MADI 04)
SYNONYMS
anti-ACRP30 (mouse) MAb (MADI 04)
anti-Adipocyte Complement Related Protein of 30kDa (mouse) MAb (MADI 04)
anti-AdipoQ (mouse) MAb (MADI 04)
anti-apM1 (mouse) MAb (MADI 04)
anti-GBP28 (mouse) MAb (MADI 04)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-513-C050
50 µg
220.00 USD
ALX-804-513-C100
100 µg
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
MADI 04
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant mouse adiponectin.
SPECIFICITY:
Recognizes both natural and recombinant mouse adiponectin. Weakly cross-reacts with human and rat adiponectin.
APPLICATION:
ELISA
(direct and indirect: 1:5’000-1:10’000)
Immunoprecipitation
(1-5μl per sample in a final reaction volume of 500-1’000μl)
Western Blot
(1:5’000-1:10’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-454
Revised 14-Jul-08
Monoclonal Antibody to Adiponectin (mouse) (MADI 1147)
SYNONYMS
anti-ACRP30 (mouse) MAb (MADI 1147)
anti-Adipocyte Complement Related Protein of 30kDa (mouse) MAb (MADI 1147)
anti-AdipoQ (mouse) MAb (MADI 1147)
anti-apM1 (mouse) MAb (MADI 1147)
anti-GBP28 (mouse) MAb (MADI 1147)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-454-C050
50 µg
195.00 USD
ALX-804-454-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
MADI 1147
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant mouse adiponectin.
SPECIFICITY:
Recognizes both natural and recombinant mouse adiponectin. Detects a band of ~30kDa by Western blot. Weakly cross-reacts with human and rat adiponectin.
APPLICATION:
ELISA
(direct and indirect: 1:5'000-1:10'000).
Western Blot
(1:5'000-1:10'000 using ECL; suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-720
Revised 29-May-07
Monoclonal Antibody to Adiponectin (rat) (RADI 264)
SYNONYMS
anti-ACRP30 (rat) MAb (RADI 264)
anti-Adipocyte Complement Related Protein of 30kDa (rat) MAb (RADI 264)
anti-AdipoQ (rat) MAb (RADI 264)
anti-apM1 (rat) MAb (RADI 264)
anti-GBP28 (rat) MAb (RADI 264)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adiponectin [ACRP30] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-720-C050
50 µg
195.00 USD
ALX-804-720-C100
100 µg
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
CLONE:
RADI 264
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant rat adiponectin.
SPECIFICITY:
Recognizes rat adiponectin. Does not cross-react with human or mouse adiponectin.
APPLICATION:
ELISA
(direct and indirect: 1:5’000-1:10’000)
Western Blot
(1:2’000-1:10’000 using ECL. Suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Related Products
ALX-201-303
Adiponectin (rat) (recombinant)
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-801-090
Revised 28-Oct-08
Monoclonal Antibody to α-Gal Epitope (Galα1-3Galβ1-4GlcNAc-R) (M86)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Xenotransplantation
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-801-090-L002
3 ml
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Pig
Others
CLONE:
M86
ISOTYPE:
Mouse IgM
FORMULATION:
Liquid. Supernatant antibody.
IMMUNOGEN:
Rabbit red blood cell membrane.
SPECIFICITY:
Recognizes synthetic and naturally produced mouse, rat and pig Galα1-3Gal epitopes on glycoproteins and glycolipids. Does not cross-react with β-Gal glycoproteins or BSA.
APPLICATION:
ELISA
Flow Cytometry
Immunohistochemistry (paraffin sections)
Western Blot
Functional Application (can be used for cytotoxicity assays for α-Gal specific pathways)
Note:
Do not use non-fat milk for blocking!
Many blocking agents from non-human mammal sources will cross-react with the antibody.
An antibody dilution of 1:5 is recommended. Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 3 years when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Description
Widely described antibody against α-galactose residues with broad cross-reactivity among different species. Useful for measuring the α-Gal epitope expression on cells, glycolipids and glycoproteins, characterization of hyperacute rejection (HAR) in organ and tissue transplantations and monitoring xenotransplantation experiments. The IgM isotype mimicks
in vivo
reactions and can be used for cytotoxicity assays for α-Gal specific pathways (addition or presence of complement necessary). Ideal as a high-throughput screening tool for inhibitors of antibody induced cytotoxicity.
Organ transplantation from pig to human result in HAR. Humans naturally produce large quantities of anti-α-Gal antibodies, which represent 1-3% of all circulating immunoglobulins and are produced by about 1% of all B cells. When pig organs or tissues are transplanted into the human body, the IgM isotype of anti-Gal binds to α-Gal epitopes, which causes activation of the complement cascade, resulting in cell lysis. This rapid activation of complement by anti-Gal IgM is an immunological barrier that poses the greatest risk of initiating HAR. The monoclonal antibody M86 to Galα1-3Gal epitopes developed by U. Galili,
et al.
is an essential tool in the study of human xenotransplantation and related research.
Product Specific Literature References
A sensitive assay for measuring alpha-Gal epitope expression on cells by a monoclonal anti-Gal antibody:
U. Galili, et al.; Transplantation
65
, 1129 (1998)
Abstract
Regulation of natural killer cell-mediated swine endothelial cell lysis through genetic remodeling of a glycoantigen:
S. Miyagawa, et al.; J. Biochem.
126
, 1067 (1999)
Abstract
alpha-Gal Oligosaccharides: Chemistry and Potential Biomedical Application
:
A. Janczuk, et al.; Current Med. Chem.
6
, 155 (1999)
Abstract
Mechanism of delayed rejection in transgenic pig-to-primate cardiac xenotransp
