ALEXIS Biochemicals: Monoclonal Antibody to Microcystins (Adda specific) (AD4G2)

Advanced Search

You are here: Product Lines > Natural Products / Antibiotics

Antibiotics

Natural Products

Toxins

ALX-380-267

Revised 20-Nov-08

LL-Z1640-2
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-267-M001		1 mg	50.00 USD
ALX-380-267-M005		5 mg	200.00 USD

Product Specification

FORMULA:	C₁₉H₂₂O₇
MW:	362.4
CAS NUMBER:	66018-38-0
SOURCE/HOST:	Isolated from Deuteromycetes sp.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in methanol, chloroform, acetone, DMSO or ethil acetate; insoluble in ethanol and n-hexane.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inhibitor of the JNK/p38 pathways. Inhibits anisomycin-induced but not TNF-induced JNK/p38 activation. Potent protein kinase inhibitor.

Product Specific Literature References

A radicicol-related macrocyclic nonaketide compound, antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific manner: K. Takehana, et al.; BBRC 257, 19 (1999) Abstract
Inhibition of HgCl2-induced mitogen-activated protein kinase activation by LL-Z1640-2 in CCRF-CEM cells: M. Matsuoka, et al.; Eur. J. Pharmacol. 409, 155 (2000) Abstract
Cadmium induces phosphorylation of p53 at serine 15 in MCF-7 cells: M. Matsuoka & H. Igisu; BBRC 282, 1120 (2001) Abstract
Effects of pentachlorophenol and tetrachlorohydroquinone on mitogen-activated protein kinase pathways in Jurkat T cells: B. Wispriyono, et al.; Environ. Health Perspect. 110, 139 (2002) Abstract; Full Text
Pharmacological inhibitors of MAPK pathways: J.M. English & M.H. Cobb; TIPS 23, 40 (2002), (Review) Abstract
Suppression of cadmium-induced JNK/p38 activation and HSP70 family gene expression by LL-Z1640-2 in NIH3T3 cells: N. Sugisawa, et al.; Toxicol. Appl. Pharmacol. 196, 206 (2004) Abstract
JNK (c-Jun NH2 terminal kinase) and p38 during ischemia reperfusion injury in the small intestine: T. Murayama, et al.; Transplantation 81, 1325 (2006) Abstract
Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide: T. Okuno, et al.; Arch. Toxicol. 80, 146 (2006) Abstract
Protein kinases as small molecule inhibitor targets in inflammation: M. Gaestel, et al.; Curr. Med. Chem. 14, 2214 (2007), (Review) Abstract
Chemistry and biology of resorcylic acid lactones: N. Winssinger & S. Barluenga; Chem. Commun. 1, 22 (2007), (Review) Abstract; Full Text

Further Categories Containing This Product:

JNK [SAPK1] / Related Products

ALX-420-023

Revised 07-Mar-07

Lobeline . hydrochloride
SYNONYMS	L-Lobeline . HCl 2-[6-(2-Hydroxy-2-phenethyl)-1-methyl-2-piperidyl]acetophenone . HCl
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Neurological Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-023-M050		50 mg	17.00 USD
ALX-420-023-M250		250 mg	50.00 USD
ALX-420-023-G001		1 g	155.00 USD

Product Specification

FORMULA:	C₂₂H₂₇NO₂ . HCl
MW:	337.5 . 36.5
CAS NUMBER:	134-63-4
MERCK INDEX:	14: 5551
RTECS:	OJ8490100
PURITY:	≥97% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	TOXIC.

Product Description

Neuronal nicotinic acetylcholine receptor agonist. Respiratory stimulant.

Further Categories Containing This Product:

Alkaloids • Acetylcholine Receptors (Nicotinic) / Related Products

ALX-350-363

Revised 26-Mar-08

Loganin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Immunomodulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-363-M025		25 mg	95.00 USD
ALX-350-363-M100		100 mg	285.00 USD

Product Specification

FORMULA:	C₁₇H₂₆O₁₀
MW:	390.4
CAS NUMBER:	18524-94-2
MERCK INDEX:	14: 5560
SOURCE/HOST:	Isolated from Cornus officinalis.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water; less soluble in 96% ethanol; sparingly soluble in 100% ethanol; insoluble in ether, petroleum ether, ethyl acetate or acetone.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL.

Product Description

Iridoid glycoside associated with immunostimmulatory and hepatoprotective activity. Key starting material for the biosynthesis of indolalkaloids. Substrate for cytochrome P450.

Product Specific Literature References

Alkaloid biosynthesis. 13. The structure, stereochemistry, and biosynthesis of loganin: A.R. Battersby, et al.; J. Chem. Soc. 721 (1969) Abstract
Biosynthesis of methylcyclopentane monoterpenoids. IV. Verbenalin: A.G. Horodysky, et al.; J. Biol. Chem. 244, 3110 (1969) Abstract; Full Text
Prevention of galactosamine - induced hepatic damage by the natural product loganin from the plant strychnos nux-vomica: studies on isolated hepatocytes and bile flow in rat: P.K.S. Visen, et al.; Phytother. Res. 12, 405 (1998)
Studies on the profile of immunostimulant activities of modified iridoid glycosides: V.T. Mathad, et al.; Bioorg. Med. Chem. 6, 605 (1998) Abstract
Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase: S. Irmler, et al.; Plant J. 24, 797 (2000) Abstract

ALX-380-293

Revised 04-Aug-08

Lomefloxacin . hydrochloride
SYNONYMS	1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-293-G001		1 g	20.00 USD
ALX-380-293-G005		5 g	80.00 USD

Product Specification

FORMULA:	C₁₇H₁₉F₂N₃O₃ . HCl
MW:	351.4 . 36.5
CAS NUMBER:	98079-52-8
MERCK INDEX:	14: 5562
RTECS:	VB1997500
PURITY:	≥89% (Assay)
APPEARANCE:	White to off-white crystalline powder.
SOLUBILITY:	Soluble in 1M sodium hydroxide (50mg/ml); sparingly soluble in water; insoluble in 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL.

Product Description

Fluoroquinolone with broad spectrum activity against Gram-negative and Gram-positive bacteria. Inhibits bacterial DNA-gyrase (topoisomerase).

Product Specific Literature References

Mechanism of action of lomefloxacin: L.J. Piddock, et al.; Antimicrob. Agents Chemother. 34, 1088 (1990) Abstract; Full Text
Antibacterial activity of lomefloxacin in a pharmacokinetic in vitro model: C. Rustige & B. Wiedemann; Antimicrob. Agents Chemother. 34, 1107 (1990) Abstract; Full Text

Further Categories Containing This Product:

Antibiotics - Topoisomerase Inhibitors • Antibiotics - DNA Replication Inhibitors

ALX-350-038

Revised 07-Apr-08

Luffariellolide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-038-M001		1 mg	95.00 USD

Product Specification

FORMULA:	C₂₅H₃₈O₃
MW:	386.6
CAS NUMBER:	111149-87-2
SOURCE/HOST:	Isolated from sponge Luffariella sp.
PURITY:	≥97% (HPLC)
APPEARANCE:	Oil.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL.

Product Description

Structurally related to manoalide (Prod. No. ALX-350-045). Anti-inflammatory phospholipase A₂ (PLA₂) inhibitor (IC₅₀=0.23µM). Less potent than manoalide, but partially reversible. Inhibits human recombinant sPLA₂ selectively over cPLA₂.

Product Specific Literature References

Luffariellolide, an anti-inflammatory sesterterpene from the marine sponge Luffariella spp.: K.F. Albizati, et al.; Experientia 43, 949 (1987)
PAF and LTB4 biosynthesis in the human neutrophil: effects of putative inhibitors of phospholipase A2 and specific inhibitors of 5-lipoxygenase: K.B. Glaser, et al.; Agents Actions 34, 89 (1991) Abstract
Characterization and pharmacological modulation of soluble phospholipase A2 generated during glycogen-induced rat peritonitis: L.A. Marshall, et al.; Agents Actions 37, 60 (1992) Abstract

Further Categories Containing This Product:

PLA2 Inhibitors • Natural Products - Anti-inflammatory Agents • Marine Natural Products

ALX-380-135

Revised 05-Jan-09

Luisol A
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-135-M001		1 mg	90.00 USD
ALX-380-135-M005		5 mg	360.00 USD

Product Specification

FORMULA:	C₁₆H₁₈O₇
MW:	322.3
SOURCE/HOST:	Isolated from Streptomyces sp. P4.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Highly oxygenated polyketide lactone.

Product Specific Literature References

Luisols A and B, new aromatic tetraols produced by an estuarine marine bacterium of the genus Streptomyces (Actinomycetales): X.C. Cheng, et al.; J. Nat. Prod. 62, 608 (1999) Abstract

ALX-350-355

Revised 26-Mar-08

Lupeol
SYNONYMS	Fagarasterol 20(29)-Lupen-3β-ol 3β-Hydroxy-20(29)-lupene
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Anti-inflammatory Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-355-M010		10 mg	35.00 USD
ALX-350-355-M050		50 mg	105.00 USD
ALX-350-355-G001		1 g	990.00 USD

Product Specification

FORMULA:	C₃₀H₅₀O
MW:	426.7
CAS NUMBER:	545-47-1
MERCK INDEX:	14: 5608
RTECS:	OK5763000
SOURCE/HOST:	Isolated from Lupinus polyphyllus.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in ether or warm 100% ethanol; insoluble in water
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Anti-inflammatory, antioxidant and antimutagenic compound. Shows preventive effects on DMBA induced DNA alkylation damage in mouse skin. Modulator of NF-κB and PI(3)K/Akt (protein kinase B; PKB) pathways. Induces Fas-mediated apoptosis via inhibition of Ras signalling. Inhibits tumor growth in mouse in vivo.

Product Specific Literature References

Anti-inflammatory activity of lupeol and lupeol linoleate in rats: T. Geetha & P. Varalakshmi; J. Ethnopharmacol. 76, 77 (2001) Abstract
Lupeol, a triterpene, inhibits early responses of tumor promotion induced by benzoyl peroxide in murine skin: M. Saleem, et al.; Pharmacol. Res. 43, 127 (2001) Abstract
Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice: M. Saleem, et al.; Oncogene 23, 5203 (2004) Abstract
Induction of antifertility with lupeol acetate in male albino rats: R.S. Gupta, et al.; Pharmacology 75, 57 (2005) Abstract
A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model: M. Saleem, et al.; Cancer Res. 65, 11203 (2005) Abstract; Full Text
Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway: M. Saleem, et al.; Carcinogenesis 26, 1956 (2005) Abstract; Full Text
Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda: J. Fotie, et al.; J. Nat. Prod. 69, 62 (2006) Abstract
Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats: S.P. Preetha, et al.; Comp. Biochem. Physiol C. Toxicol. Pharmacol. 143, 333 (2006) Abstract
Role of lupeol and lupeol linoleate on lipemic-oxidative stress in experimental hypercholesterolemia: V. Sudhahar, et al.; Life Sci. 78, 1329 (2006) Abstract
Preventive effects of lupeol on DMBA induced DNA alkylation damage in mouse skin: N. Nigam, et al.; Food Chem. Toxicol. 45, 2331 (2007) Abstract
Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model: T.K. Lee, et al.; Cancer Res. 67, 8800 (2007) Abstract

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Natural Products - Apoptosis Inducers & Inhibitors

ALX-385-007

Revised 07-Oct-08

Luteolin
SYNONYMS	3',4',5,7-Tetrahydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-007-M010		10 mg	15.00 USD
ALX-385-007-M050		50 mg	45.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₆
MW:	286.2
CAS NUMBER:	491-70-3
MERCK INDEX:	14: 5614
RTECS:	LK9275210
PURITY:	≥90%
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in methanol, alkaline solutions; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Antioxidant flavonoid. Inhibits VEGF-induced angiogenesis. Inhibitor of phosphoinositide 3-kinase (PI(3)K). Inhibitor of fatty acid synthase (FAS). Apoptosis inducer.

Product Specific Literature References

Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity: E. Bagli, et al.; Cancer Res. 64, 7936 (2004)
Dietary flavonoids: bioavailability, metabolic effects, and safety: J.A. Ross & C.M. Kasum; Annu. Rev. Nutr. 221, 19 (2002), (Review) Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review) Abstract

Further Categories Containing This Product:

Fatty Acid Synthase [FAS] / Related Products • Phosphoinositide 3-kinase [PI(3)K] / Related Products • Natural Products for Angiogenesis Research • Natural Products - Antioxidants • Free Radical Scavengers • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Other Signal Transduction Pathway Modulators

ALX-550-002

Revised 07-Oct-08

LY-83,583
SYNONYMS	6-(Phenylamino)-5,8-quinolinedione 6-Anilino-5,8-quinolinedione
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Neurotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-002-M005		5 mg	55.00 USD
ALX-550-002-M025		25 mg	220.00 USD
ALX-550-002-M100		100 mg	390.00 USD

Product Specification

FORMULA:	C₁₅H₁₀N₂O₂
MW:	250.3
CAS NUMBER:	91300-60-6
SOURCE/HOST:	Synthetic.
PURITY:	≥95%
APPEARANCE:	Dark red powder.
SOLUBILITY:	Soluble in methanol or diluted aqueous acid. Insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL.

Product Description

Competitive inhibitor of soluble guanylyl cyclase (sGC) (IC₅₀=2µM) and of cGMP production. Neurotoxin.

Product Specific Literature References

Pharmacologic analysis of two novel inhibitors of leukotriene (slow reacting substance) release: J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther. 229, 681 (1984) Abstract
LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase: A. Mülsch, et al.; J. Pharmacol. Exp. Ther. 247, 283 (1988) Abstract
Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells: D. Beasley, et al.; J. Clin. Invest. 87, 602 (1991) Abstract
Modification by LY 83583 and methylene blue of relaxation induced by nitric oxide, glyceryl trinitrate, sodium nitroprusside and atriopeptin in aortae of the rat, guinea-pig and rabbit: T. Kawada, et al.; Gen. Pharmacol. 25, 1361 (1994) Abstract
A comparative study of the effects of three guanylyl cyclase inhibitors on the L-type Ca2+ and muscarinic K+ currents in frog cardiac myocytes: N. Abi-Gerges, et al.; Br. J. Pharmacol. 121, 1369 (1997) Abstract
Guanylyl cyclase inhibition reduces contractility and decreases cGMP and cAMP in isolated rat hearts: R.E. Klabunde, et al.; Cardiovasc. Res. 37, 676 (1998) Abstract
Histochemical detection of quinone reductase activity in situ using LY 83583 reduction and oxidation: T.H. Murphy, et al.; J. Neurochem. 70, 2156 (1998) Abstract
Inhibition of nitric oxide formation and superoxide generation during reduction of LY83583 by neuronal nitric oxide synthase: Y. Kumagai, et al.; Eur. J. Pharmacol. 360, 213 (1998) Abstract
Nitric oxide stimulates cGMP production and mimics synaptic responses in metacerebral neurons of Aplysia: H.Y. Koh and J.W. Jacklet; J. Neurosci. 19, 3818 (1999) Abstract; Full Text
LY-83583 stimulates glucose transporter-1-mediated glucose transport independent of changes in cGMP levels: R.K. Prasad, et al.; Eur. J. Pharmacol. 366, 101 (1999) Abstract
The effects of intracerebroventricular application of 8-Br-cGMP and LY-83,583, a guanylyl cyclase inhibitor, on sleep-wake activity in rats
: A.C. Ribeiro & L. Kapas; Brain Res. 1049, 25 (2005) Abstract