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Antibiotics - ATPase Inhibitors
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ALX-350-315 Revised 03-Apr-08
Agelasine D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-315-M001   1 mg 185.00 USD Add To Cart
Product Specification
FORMULA: C26H40N5
MW: 422.6
CAS NUMBER: 92664-80-7
SOURCE/HOST: Isolated from the sponge Agelas nakamurai.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Displays broad spectrum of antibacterial activities. Antineoplastic compound. Associated with contractive responses of smooth muscles and inhibition of Na+/K+-ATPase.
Product Specific Literature References
(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities: A. Vik, et al.; J. Nat. Prod. 69, 381 (2006) Abstract
Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs: A. Vik, et al.; Bioorg. Med. Chem. 15, 4016 (2007) Abstract
Further Categories Containing This Product:
Na+/K+-ATPase/Related Products • Natural Products - Antitumor Reagents • Antitumor Agents (Anti-proliferative) • Antibiotics - ATPase Inhibitors
 
 
ALX-350-322 Revised 20-Feb-08
Equisetin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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ALX-350-322-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C22H31NO4
MW: 373.5
CAS NUMBER: 57749-43-6
SOURCE/HOST: Isolated from Fusarium equiseti.
PURITY: ≥97% (HPLC)
APPEARANCE: Brown oily solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Fungal metabolite with antibiotic and cytotoxic activity. Inhibitor of mitochondrial ATPases and HIV-1 integrase. Mycotoxin.
Product Specific Literature References
Antibiotic produced by Fusarium equiseti NRRL 5537: H.R. Burmeister, et al.; Antimicrob. Agents Chemother. 5, 634 (1974) Abstract
Equisetin, an antibiotic from Fusarium equiseti NRRL 5537, identified as a derivative of N-methyl-2,4-pyrollidone: R.F. Vesonder, et al.; J. Antibiot. 32, 759 (1979) Abstract
The effect of equisetin on energy-linked reactions in Rhodospirillum rubrum chromatophores: P. Nyren and A. Strid; Arch. Biochem. Biophys. 268, 659 (1989) Abstract
Characterization of the Fusarium toxin equisetin: the use of phenylboronates in structure assignment: N. J. Phillips, et al.; JACS 111, 8223 (1989)
Characterization of a mitochondrial inorganic pyrophosphatase in Saccharomyces cerevisiae: M. Lundin, et al.; Biochim. Biophys. Acta 1098, 217 (1992) Abstract
Effects of equisetin on rat liver mitochondria: evidence for inhibition of substrate anion carriers of the inner membrane: T. Konig, et al.; J. Bioenerg. Biomembr. 25, 537 (1993) Abstract
Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase: S.B. Singh, et al.; Tetrahedron Lett. 39, 2243 (1998)
Isolation and characterization of novel human immunodeficiency virus integrase inhibitors from fungal metabolites: D. Hazuda, et al.; Antivir. Chem. Chemother. 10, 63 (1999) Abstract
Phytotoxicity of equisetin and epi-equisetin isolated from Fusarium equiseti and F. pallidoroseum: M.H. Wheeler, et al.; Mycological Res. 103, 967 (1999)
A short stereoselective total synthesis of the fusarium toxin equisetin: L.T. Burke, et al.; Org. Lett. 2, 3611 (2000) Abstract
Enantioselective total synthesis of (−)-equisetin using a Me3Al-mediated intramolecular Diels–Alder reaction: K. Yuki, et al.; Tetrahedron Lett. 427, 2517 (2001)
Natural products with anti-HIV activity from marine organisms: L.A. Tziveleka, et al.; Curr. Top. Med. Chem. 3, 1512 (2003) Abstract
Total synthesis of the Fusarium toxin equisetin: L.T. Burke, et al.; Org. Biomol. Chem. 3, 274 (2005) Abstract
Equisetin biosynthesis in Fusarium heterosporum: J.W. Sims; Chem. Commun. 2005, 186
Molecular biology of Fusarium mycotoxins: A.E. Desjardins & R.H. Proctor; Int. J. Food Microbiol. 119, 47 (2007) Abstract
Further Categories Containing This Product:
Mycotoxins • HIV/AIDS/Related Products
 
 
ALX-380-030 Revised 17-Oct-07
Bafilomycin A1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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ALX-380-030-C100   100 µg 70.00 USD Add To Cart
ALX-380-030-M001   1 mg 210.00 USD Add To Cart
Product Specification
FORMULA: C35H58O9
MW: 622.8
CAS NUMBER: 88899-55-2
SOURCE/HOST: Isolated from Streptomyces griseus.
PURITY: ≥95%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Valuable tool for distinguishing among different types of ATPases. Inhibitor of endosomal acidification.
Product Specific Literature References
Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. 37, 110 (1984) Abstract
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells: E.J. Bowman, et al.; PNAS 85, 7972 (1988) Abstract
The evolution of H+-ATPases [see comments]: N. Nelson & L. Taiz; TIPS 14, 113 (1989), (Review) Abstract
Kinetic studies of chromaffin granule H+-ATPase and effects of bafilomycin A1: H. Hanada, et al.; BBRC 170, 873 (1990) Abstract
Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption: K. Sundqui, et al.; BBRC 168, 309 (1990) Abstract
The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase: T. Umata, et al.; J. Biol. Chem. 265, 21940 (1990) Abstract; Full Text
Bafilomycin A1 inhibits the targeting of lysosomal acid hydrolases in cultured hepatocytes: K. Oda, et al.; BBRC 178, 369 (1991) Abstract
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells: T. Yoshimori, et al.; J. Biol. Chem. 266, 17707 (1991) Abstract; Full Text
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993) Abstract
Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, blocks lysosomal cholesterol trafficking in macrophages: T. Furuchi, et al.; J. Biol. Chem. 268, 27345 (1993) Abstract; Full Text
Bafilomycin inhibits proton flow through the H+ channel of vacuolar proton pumps: B.P. Crider, et al.; J. Biol. Chem. 269, 17379 (1994) Abstract; Full Text
Active vacuolar H+ATPase is required for both endocytic and exocytic processes during viral infection of BHK-21 cells: H. Palokangas, et al.; J. Biol. Chem. 269, 17577 (1994) Abstract; Full Text
Inositol trisphosphate-dependent and -independent Ca2+ mobilization pathways at the vacuolar membrane of Candida albicans: C.M. Calvert & D. Sanders; J. Biol. Chem. 270, 7272 (1995) Abstract; Full Text
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein: C. Haass, et al.; J. Biol. Chem. 270, 6186 (1995) Abstract; Full Text
Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases: J. Knops, et al.; J. Biol. Chem. 270, 2419 (1995) Abstract; Full Text
Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death: T. Nishihara, et al.; BBRC 212, 255 (1995) Abstract
Inhibition of mitogen-induced DNA synthesis by bafilomycin A1 in Swiss 3T3 fibroblasts: A.J. Saurin, et al.; Biochem. J. 313, 65 (1996) Abstract
Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006), Review Abstract
Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator: T. Okiyoneda, et al.; Biochim. Biophys. Acta 1763, 1017 (2006) Abstract
Further Categories Containing This Product:
H+-ATPase/Related Products • Vesicles & Membrane Trafficking Other Products • Autophagy Other Products • Antibiotics - Apoptosis Inducers & Inhibitors
 
 
ALX-380-034 Revised 30-Jul-08
Concanamycin A
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SYNONYMS Folimycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - ATPase Inhibitors
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ALX-380-034-C025   25 µg 55.00 USD Add To Cart
ALX-380-034-C100   100 µg 180.00 USD Add To Cart
ALX-380-034-M001   1 mg 750.00 USD Add To Cart
Product Specification
FORMULA: C46H75NO14
MW: 866.1
CAS NUMBER: 80890-47-7
RTECS: CB9732000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥96% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol, DMSO or acetonitrile; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: VERY TOXIC.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Antibiotic. More potent and specific H+-ATPase inhibitor than bafilomycin A1 (Prod. No. ALX-380-030). Inhibits acidification of organelles such as lysosomes and the Golgi apparatus. Blocks cell surface expression of viral glycoproteins without affecting their synthesis. Exhibits cytotoxic effects in a number of cell lines in a cell viability assay. Induces nitric oxide (NO) production.
Product Specific Literature References
Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 37, 1333 (1984) Abstract
Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells: E.J. Bowman, et al.; PNAS 85, 7972 (1988) Abstract
Structure and function of vacuolar class of ATP-driven proton pumps: M. Forgac; Physiol. Rev. 69, 765 (1989) Abstract
Intravesicular acidification correlates with binding of ADP- ribosylation factor to microsomal membranes: S. Zeuzem, et al.; PNAS 89, 6619 (1992) Abstract
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32, 3902 (1993) Abstract
Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus: M. Muroi, et al.; Cell Struct. Funct. 18, 139 (1993) Abstract
Folimycin (concanamycin A), an inhibitor of V-type H(+)-ATPase, blocks cell-surface expression of virus-envelope glycoproteins: M. Muroi, et al.; BBRC 193, 999 (1993) Abstract
Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993) Abstract
Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells: M. Yilla, et al.; J. Biol. Chem. 268, 19092 (1993) Abstract; Full Text
Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death: T. Nishihara, et al.; BBRC 212, 255 (1995) Abstract
Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells: F.J. Sharom, et al.; Biochem. J. 308 (Pt2), 381 (1995) Abstract
Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c: M. Huss, et al.; J. Biol. Chem. 277, 40544 (2002) Abstract
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449: S.F. Haydock, et al.; Microbiology 151, 3161 (2005) Abstract; Full Text
Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells: J. Hong, et al.; J. Pharmacol. Exp. Ther. 319, 672 (2006) Abstract
Related Products
Further Categories Containing This Product:
Antibiotics - Nitric Oxide Pathway Modulators • H+-ATPase/Related Products • Antitumor Antibiotics
 
 
ALX-380-036 Revised 10-Dec-07
Oligomycin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-036-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C45H74O11
MW: 791.1
CAS NUMBER: 579-13-5
MERCK INDEX: 14: 6833
RTECS: RK3328000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5339.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL.

Product Description
Major component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1F0), preventing phosphoryl group transfer. Induces apoptosis. Induces autophagy in the IPLB-LdFB insect cell line.
Product Specific Literature References
Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Egr. 2, 31 (1960) Abstract
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000) Abstract; Full Text
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2000) Abstract; Full Text
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004) Abstract
Oligomycin A induces autophagy in the IPLB-LdFB insect cell line: G. Tettamanti, et al.; Cell Tissue Res. 326, 179 (2006) Abstract
Further Categories Containing This Product:
Antibiotics - ATPase Inhibitors • H+-ATPase/Related Products • Antitumor Antibiotics • Respiratory Chain Other Products • Antibiotics - Antifungal
 
 
ALX-380-037 Revised 20-Jun-08
Oligomycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-037-M005   5 mg 50.00 USD Add To Cart
ALX-380-037-M010   10 mg 95.00 USD Add To Cart
Product Specification
MW: 789.3
CAS NUMBER: 1404-19-9
MERCK INDEX: 14: 6833
RTECS: RK3325000
SOURCE/HOST: Isolated from Streptomyces diastatochromogens.
PURITY: ≥90% (mixture of oligomycin A, B, and C (~65% oligomycin A))
APPEARANCE: White to faint yellow powder.
SOLUBILITY: Soluble in 100% ethanol, methanol (10mg/ml) or acetone (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL. MAY BE MUTAGENIC.

Product Description
Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1), preventing phosphoryl group transfer. Induces apoptosis.
Product Specific Literature References
Inhibition of the Na(+)-Ca++ exchanger enhances anoxia and glucopenia- induced [3H]aspartate release in hippocampal slices: S. Amoroso, et al.; J. Pharmacol. Exp. Ther. 264, 515 (1993) Abstract
Cyclosporin A suppression of uncoupling in liver mitochondria of ground squirrel during arousal from hibernation: N.N. Brustovetsky, et al.; FEBS Lett. 315, 233 (1993) Abstract
The lipophilic weak base (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4- piperidinopyridine (AU-1421) is a potent protonophore type cationic uncoupler of oxidative phosphorylation in mitochondria: H. Nagamune, et al.; Biochim. Biophys. Acta 1141, 231 (1993) Abstract
Mitochondrial respiratory chain inhibitors induce apoptosis: E.J. Wolvetang, et al.; FEBS Lett. 339, 40 (1994) Abstract
Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program: J. Zhuang, et al.; J. Biol. Chem. 273, 15628 (1998) Abstract; Full Text
Apoptosis in factor-dependent haematopoietic cells is linked to calcium- sensitive mitochondrial rearrangements and cytoskeletal modulation: J. Garland, et al.; Br. J. Haematol. 109, 221 (2000) Abstract
Properties of DNA fragmentation activity generated by ATP depletion: N. Nakamura & Y. Wada; Cell Death Differ. 7, 477 (2000) Abstract
Further Categories Containing This Product:
H+-ATPase/Related Products • Antitumor Antibiotics • Respiratory Chain Other Products • Antibiotics - ATPase Inhibitors • Antibiotics - Antifungal
 
 
ALX-380-038 Revised 10-Dec-07
Oligomycin B
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SYNONYMS 28-Oxooligomycin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-038-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C45H72O12
MW: 805.1
CAS NUMBER: 11050-94-5
MERCK INDEX: 14: 6833
RTECS: RK3330000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5339.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL. MAY BE MUTAGENIC.

Product Description
Minor component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1F0), preventing phosphoryl group transfer. Induces apoptosis.
Product Specific Literature References
Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Egr. 2, 31 (1960) Abstract
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000) Abstract; Full Text
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2000) Abstract; Full Text
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004) Abstract
Further Categories Containing This Product:
H+-ATPase/Related Products • Antitumor Antibiotics • Respiratory Chain Other Products • Antibiotics - ATPase Inhibitors • Antibiotics - Antifungal
 
 
ALX-380-039 Revised 10-Dec-07
Oligomycin C
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SYNONYMS 12-Deoxyoligomycin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-380-039-M001   1 mg 330.00 USD Add To Cart
Product Specification
FORMULA: C45H74O10
MW: 775.1
CAS NUMBER: 11052-72-5
MERCK INDEX: 14: 6833
RTECS: RK3335000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5339.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL.

Product Description
Minor component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1F0), preventing phosphoryl group transfer. Induces apoptosis.
Product Specific Literature References
Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Engr. 2, 31 (1960) Abstract
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000) Abstract; Full Text
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2002) Abstract; Full Text
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004) Abstract
Further Categories Containing This Product:
H+-ATPase/Related Products • Antitumor Antibiotics • Respiratory Chain Other Products • Antibiotics - ATPase Inhibitors • Antibiotics - Antifungal
 
 
ALX-380-063 Revised 03-Apr-08
Bafilomycin B1