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Autophagy-related Proteins [APG; ATG] / Related Products
You are here: Product Lines > Cell Death / Apoptosis / Autophagy > Autophagy / Related Products > Autophagy-related Proteins [APG; ATG] / Related Products
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ALX-804-382 Revised 21-Feb-08
Monoclonal Antibody to Hrs and Hrs-2 (A-5)
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SYNONYMS anti-HGS MAb (A-5)
anti-Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate MAb (A-5)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Hepatocyte Growth Factor [HGF] & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-382-C050   50 µg 290.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
CLONE: A-5
ISOTYPE: Mouse IgG2a
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS containing 10% glycerol.
IMMUNOGEN: Recombinant full length rat Hrs-2 (hepatocyte growth factor-regulated tyrosine kinase substrate).
SPECIFICITY: Recognizes human, mouse, rat and monkey Hrs (HGS) and Hrs-2.
APPLICATION: Immunohistochemistry (1:100-1:1'000)
Immunoprecipitation (2µg/ml)
Western Blot (1:2'000-1:3'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 3 months when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Isoform-specific exocytotic protein mRNA expression in hypothalamic magnocellular neurons: regulation after osmotic challenge: G. Jacobsson, et al.; Neuroendocrinology 70, 392 (1999) Abstract
The cellular and developmental expression of hrs-2 in rat: S. Tsujimoto, et al.; Eur. J. Neurosci. 11, 3047 (1999) Abstract
Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15: A.J. Bean, et al.; J. Biol. Chem. 275, 15271 (2000) Abstract; Full Text
Distinct protein domains are responsible for the interaction of Hrs-2 with SNAP-25. The role of Hrs-2 in 7 S complex formation: S. Tsujimoto & A.J. Bean; J. Biol. Chem. 275, 2938 (2000) Abstract; Full Text
SNAP-25-associated Hrs-2 protein colocalizes with AQP2 in rat kidney collecting duct principal cells: A. Shukla, et al.; Am. J. Physiol. Renal. Physiol. 281, F546 (2001) Abstract; Full Text
CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling: Q. Yan, et al.; Mol. Biol. Cell 16, 2470 (2005) Abstract; Full Text
Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK: S.K. Rayala, et al.; J. Biol. Chem. 281, 4395 (2006) Abstract; Full Text
General Information
Hrs/Hgs (hepatocyte growth factor-regulated tyrosine kinase substrate) is a tyrosine-phosphorylated member of a protein family characterized by a conserved 3´-phosphoinositide-interacting RING zinc finger domain, the so called FYVE finger. A variant of Hrs, Hrs-2 is an ATPase that has been shown to play a regulatory role in the docking and/or fusion of synaptic vesicles to plasma membranes through a calcium-regulated interaction with SNAP-25. Hrs-2 physically interacts with Eps15, a protein required for receptor-mediated endocytosis. The Hrs-2/Eps15 interaction is calcium dependent, inhibited by SNAP-25 and alpha-adaptin, and results in the inhibition of receptor-mediated endocytosis. Immunoelectron microscopy reveals Hrs-2 localization on the limiting membrane of multivesicular bodies, organelles in the endosomal pathway. Recent data suggest that Hrs-2 acts to provide communication between endo- and exocytic processes.
Further Categories Containing This Product:
Vesicles & Membrane Trafficking Other Products • Monoclonal Antibodies • Autophagy-related Proteins [APG; ATG] / Related Products
 
 
ALX-210-955 Revised 11-Mar-08
Polyclonal Antibody to WIPI-1 (AT130)
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SYNONYMS anti-WD Repeat Domain Phosphoinositide-interacting Protein 1 PAb (AT130)
anti-WD40 Repeat Protein Interacting with Phosphoinositides of 49kDa PAb (AT130)
anti-WIPI 49kDa PAb (AT130)
anti-Atg18 Protein Homolog PAb (AT130)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Autophagy-related Proteins [APG; ATG] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-955-C100   100 µg 350.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa in the middle of human WIPI-1.
SPECIFICITY: Recognizes human and mouse WIPI-1.
APPLICATION: Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
WIPI-1 (WD-repeat protein interacting with phosphoinosides) is highly expressed in a variety of tumors. It interacts with phosphatidylinositol-3-P and this interaction is required for recruitment to membranes. WIPI-1 contains the signature motif LXXLL for nuclear receptor association and it binds to estrogen and androgen receptors in vitro. The WIPI-1 homolog in S. cerevisiae (Atg18) plays a role in autophagy. WIPI-1 accumulates in multi-membrane structures under autophagic conditions and it co-localizes with LC3.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy: T. Proikas-Cezanne, et al.; FEBS Lett. 581, 3396 (2007) Abstract
Related Products
Further Categories Containing This Product:
Estrogen & Estrogen Receptors / Related Products • Androgens & Androgen Receptors / Related Products • Polyclonal Antibodies • Inositols & Inositolphosphates / Related Products
 
 
ALX-210-954 Revised 22-Jul-08
Polyclonal Antibody to WIPI-1 (human) (AT129)
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SYNONYMS anti-WD Repeat Domain Phosphoinositide-interacting Protein 1 (human) PAb (AT129)
anti-WD40 Repeat Protein Interacting with Phosphoinositides of 49kDa (human) PAb (AT129)
anti-WIPI 49kDa (human) PAb (AT129)
anti-Atg18 Protein Homolog (human) PAb (AT129)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Autophagy-related Proteins [APG; ATG] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-954-C050   50 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa of C-terminal human WIPI-1.
SPECIFICITY: Recognizes human WIPI-1.
APPLICATION: Western blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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General Information

WIPI-1 (WD-repeat protein interacting with phosphoinosides) is highly expressed in a variety of tumors. It interacts with phosphatidylinositol-3-P and this interaction is required for recruitment to membranes. WIPI-1 contains the signature motif LXXLL for nuclear receptor association and it binds to estrogen and androgen receptors in vitro. The WIPI-1 homolog in S. cerevisiae (Atg18) plays a role in autophagy. WIPI-1 accumulates in multi-membrane structures under autophagic conditions and it co-localizes with LC3.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy: T. Proikas-Cezanne, et al.; FEBS Lett. 581, 3396 (2007) Abstract
Related Products
Further Categories Containing This Product:
Estrogen & Estrogen Receptors / Related Products • Androgens & Androgen Receptors / Related Products • Polyclonal Antibodies • Inositols & Inositolphosphates / Related Products
 
 
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