ALEXIS Biochemicals: FeTMPyP . pentachloride

ALX-430-092

Revised 28-Jan-05

FeTMPyP . pentachloride
SYNONYMS	Iron (III) tetrakis(N-methyl-4'-pyridyl)porphyrin . 5Cl
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Porphyrins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-092-M010		10 mg	43.00 USD

Product Specification

FORMULA:	C₄₄H₃₆FeN₈ . 5Cl
MW:	732.7 . 177.3
CAS NUMBER:	133314-07-5
PURITY:	≥98%
APPEARANCE:	Black solid.
SOLUBILITY:	Soluble in aqueous buffers or isotonic saline.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 2 years after receipt when stored at –20°C.
HANDLING:	Protect from light and moisture.

Product Description

Synthetic porphyrin complexed with iron which acts as a peroxynitrite decomposition complex. Catalyzes the isomerization of peroxynitrite to nitrate under physiological conditions. Effectively prevents the oxidation of lipid components by peroxynitrite. Also catalytically decomposes superoxide radicals. Irridation of the aqueous solution at 335nm releases hydroxyl radicals. It can also serve as a potential drug for reactive oxygen species (ROS) detoxification.

Product Specific Literature References

Peroxynitrite decomposition catalysts: M.K. Stern, et al.; JACS 118, 8735 (1996)
Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies: J.A. Hunt, et al.; Chem. Biol. 4, 845 (1997) Abstract
Peroxynitrite rapidly permeates phospholipid membranes: S.S. Marla, et al.; PNAS 94, 14243 (1997) Abstract
Characterization of the cytoprotective action of peroxynitrite decomposition catalysts: T.P. Misko, et al.; J. Biol. Chem. 273, 15646 (1998) Abstract; Full Text
Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage: D. Salvemini, et al.; Br. J. Pharmacol. 127, 685 (1999) Abstract
Methamphetamine generates peroxynitrite and produces dopaminergic neurotoxicity in mice: protective effects of peroxynitrite decomposition catalyst: S.Z. Imam, et al.; Brain Res. 837, 15 (1999) Abstract

Further Categories Containing This Product:

Peroxynitrite / Scavengers / Detection

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