ALEXIS Biochemicals: Fenofibrate

ALX-270-481

Revised 11-Aug-08

Fenofibrate
SYNONYMS	2-[4-(4-Chlorobenzoyl)phenoxy]-2-methyl-propanoic acid 1-methylethyl ester Procetofen
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PPAR Agonists

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-481-G005		5 g	30.00 USD

Product Specification

FORMULA:	C₂₀H₂₁ClO₄
MW:	360.8
CAS NUMBER:	49562-28-9
MERCK INDEX:	14: 3978
RTECS:	UA2453400
PURITY:	≥98% (UPLC)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in acetone, ether, DMSO or dimethyl formamide; slightly soluble in 100% ethanol or methanol; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL.

Product Description

Hypolipidemic compound. PPARα (peroxisome proliferator-activated receptor α) agonist (EC₅₀=18µM for mouse and EC₅₀=30µM for human PPARα). Also binds to PPARγ, but with at least 10-fold less affinity and is inactive at PPARδ (up to EC₅₀=100µM).

Product Specific Literature References

Inhibition of membrane-bound hepatic 3 hydroxy-3 methyl glutaryl CoA reductase as the consequence of altered membrane fluidity: E. Wulfert, et al.; Artery 9, 120 (1981) Abstract
Fenofibrate protects lipoproteins from lipid peroxidation: synergistic interaction with alpha-tocopherol: E. Chaput, et al.; Lipids 34, 497 (1999) Abstract
Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological study: S. Pierno, et al.; Br. J. Pharmacol. 149, 909 (2006) Abstract; Full Text
In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer: S.A. Saidi, et al.; Mol. Cancer 5, 13 (2006) Abstract; Full Text
PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition: D. Panigrahy, et al.; PNAS 105, 985 (2008) Abstract; Full Text

ALX-270-256	Clofibrate
ALX-270-475	Ciprofibrate