ALEXIS Biochemicals: Ferutinin (high purity)

ALX-350-098

Revised 05-Apr-08

Ferutinin (high purity)
SYNONYMS	Tefestrol (high purity)
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products - DNA Regulation / Transcription

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-098-M001		1 mg	35.00 USD
ALX-350-098-M005		5 mg	100.00 USD
ALX-350-098-M010		10 mg	170.00 USD

Product Specification

FORMULA:	C₂₂H₃₀O₄
MW:	358.5
SOURCE/HOST:	Semisynthetic.
PURITY:	≥98%
SOLUBILITY:	Soluble in acetone, dichloromethane, DMSO or ethyl acetate.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Potent, naturally occuring non-steroid estrogenic compound. Agonist for estrogen receptor (ER) α and agonist/antagonist for ERβ with higher binding affinity than tamoxifen (Prod. No. ALX-550-095) for both ERs. Electrogenic Ca²⁺ ionophore inducing mitochondrial depolarisation which can be completely blocked by cyclosporin A (Prod. No. ALX-380-002), suggesting that ferutinin opens the mitochondrial permeability transition pore (mPTP). In a concentration range of 1-50µM ferutinin increases the permeability of thymocytes, mitochondria, sarcoplasmic reticulum, liposomes and bilayer lipid membranes for Ca²⁺.

Product Specific Literature References

Ferutinine structure: A.I. Saidkhodjaev, et al.; Chem. Nat. Comp. 1, 28 (1973)
Ionophoretic properties of ferutinin: M.V. Zamaraeva, et al.; Cell Calcium 22, 235 (1997) Abstract
Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers: A.Y. Abramov, et al.; Biochim. Biophys. Acta 1512, 98 (2001) Abstract
Daucane phytoestrogens: a structure-activity study: G. Appendino, et al.; J. Nat. Prod. 65, 1612 (2002) Abstract
Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and ERbeta: differential transcription activity between ferutinine-liganded ER(alpha) and ERbeta: K. Ikeda, et al.; BBRC 291, 354 (2002) Abstract
Actions of ionomycin, 4-BrA23187 and a novel electrogenic Ca2+ ionophore on mitochondria in intact cells: A.Y. Abramov & M.R. Duchen; Cell Calcium 33, 101 (2003) Abstract

Further Categories Containing This Product:

Ionophores Other Products • MPTP [Mitochondrial Transition Pore] / Related Products • Estrogen & Estrogen Receptors / Related Products

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