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ALX-350-001 Revised 05-Apr-08
Forskolin
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SYNONYMS Colforsin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-001-M001   1 mg 20.00 USD Add To Cart
ALX-350-001-M005   5 mg 52.00 USD Add To Cart
ALX-350-001-M010   10 mg 85.00 USD Add To Cart
ALX-350-001-M025   25 mg 185.00 USD Add To Cart
ALX-350-001-M050   50 mg 325.00 USD Add To Cart
Product Specification
FORMULA: C22H34O7
MW: 410.5
CAS NUMBER: 66575-29-9
MERCK INDEX: 14: 2476
SOURCE/HOST: Isolated from Coleus forskohlii.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to green crystals.
SOLUBILITY: Soluble in ethyl acetate (10mg/ml), anhydrous DMSO (5mg/ml) or 100% ethanol (6mg/ml). DMSO is the recommended solvent for activation of cAMP.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stock solutions in DMSO are stable for up to 4 months when stored at +4°C.

Product Description
Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP. Widely used tool for the investigation of the role of cAMP as a second messenger with a broad range of potential therapeutic applications. Inotropic agent and vasodilator. Induces platelet aggregation. Inhibits ion channels by a mechanism that does not involve cAMP. Non-competitive inhibitor of nicotinic acetylcholine receptors.
Product Specific Literature References
Forskolin: a unique diterpene activator of cyclic AMP-generating systems: K.B. Seamon & J.W. Daly; J. Cyclic Nucleotide Res. 7, 201 (1981), Review Abstract
Forskolin, an activator of adenylate cyclase, increases CA2+-dependent electrical activity induced by glucose in mouse pancreatic B cells: J.C. Henquin, et al.; Endocrinology 112, 2218 (1983) Abstract
Pharmacology and inotropic potential of forskolin in the human heart: M.R. Bristow, et al.; J. Clin. Invest. 74, 212 (1984) Abstract
Forskolin and antidiuretic hormone stimulate a Ca2+-activated K+ channel in cultured kidney cells: S.E. Guggino, et al.; Am. J. Physiol. 249, F448 (1985) Abstract
Use of forskolin to study the relationship between cyclic AMP formation and bone resorption in vitro: U.H. Lerner, et al.; Biochem J. 240, 529 (1986) Abstract
Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?: A. Laurenza, et al.; Trends Pharmacol. Sci. 10, 442 (1989), Review Abstract
Effect of forskolin on cytosolic Ca++ level and contraction in vascular smooth muscle: A. Abe & H. Karaki; J. Pharmacol. Exp. Ther. 249, 895 (1989) Abstract
Forskolin acts as a noncompetitive inhibitor of nicotinic acetylcholine receptors: M.L. Aylwin & M.M. White; Mol. Pharmacol. 41, 908 (1992) Abstract
The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release: J.T. Christenson, et al.; Vasa 24, 56 (1995) Abstract
Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling: P.A. Insel & R.S. Ostrom; Cell Mol. Neurobiol. 23, 305 (2003), Review Abstract
Effect of forskolin on the expression of claudin-5 in human trophoblast BeWo cells: M. Harada, et al.; Pharmazie 62, 291 (2007) Abstract
 
 

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