ALEXIS Biochemicals: Furegrelate sodium

ALX-270-120

Revised 30-Jul-08

Furegrelate sodium
SYNONYMS	U-63557A Sodium furegrelate
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Thromboxanes / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-120-M010		10 mg	90.00 USD
ALX-270-120-M050		50 mg	360.00 USD

Product Specification

FORMULA:	C₁₅H₁₀NO₃ . Na
MW:	252.2 . 23.0
CAS NUMBER:	85666-17-7
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in water (15mg/ml), methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year when stored at -20°C. Before use, prepare a stock solution by dissolving the product in water. Stock solutions will be stable for at least 1 month if stored at 0°C in an oxygen-free environment.
IDENTITY:	Identity determined by MS, ¹H-NMR and ¹³C-NMR.

Product Description

Potent and selective orally active inhibitor of thromboxane A₂synthase.

Product Specific Literature References

Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate: R.R. Gorman, et al.; Prostaglandins 26, 325 (1983) Abstract
Thromboxane A2 synthase inhibitors. 5-(3-Pyridylmethyl)benzofuran-2-carboxylic acids: R.A. Johnson, et al.; J. Med. Chem. 29, 1461 (1986) Abstract
Pharmacokinetics of furegrelate after oral administration to normal humans: D.B. Lakings, et al.; Pharm. Res. 6, 53 (1989) Abstract
Thromboxane synthase activity and platelet function after furegrelate administration in man: J.S. Mohrland, et al.; J. Clin. Pharmacol. 29, 53 (1989) Abstract
Multiple dose trial of the thromboxane synthase inhibitor furegrelate in normal subjects: J.S. Mohrland, et al.; Eur. J. Clin. Pharmacol. 38, 485 (1990) Abstract

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