ALEXIS Biochemicals: GW9662

ALX-270-356

Revised 04-May-06

GW9662
SYNONYMS	2-Chloro-5-nitrobenzanilide
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PPAR Antagonists

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-356-M001		1 mg	10.00 USD
ALX-270-356-M005		5 mg	35.00 USD
ALX-270-356-M025		25 mg	140.00 USD

Product Specification

FORMULA:	C₁₃H₉N₂O₃Cl
MW:	276.7
CAS NUMBER:	22978-25-2
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 100% ethanol, DMSO or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1µM. Much more potent antagonist than BADGE (Prod. No. ALX-270-353).

Product Specific Literature References

IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1: A.C. Bendixen, et al.; PNAS 98, 2443 (2001) Abstract; Full Text
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662: L.M. Leesnitzer, et al.; Biochemistry 41, 6640 (2002) Abstract
Activation of peroxisome proliferator-activated receptor gamma inhibits osteoprotegerin gene expression in human aortic smooth muscle cells: M. Fu, et al.; BBRC 294, 597 (2002) Abstract
15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications: T.M. Lindström & P.R. Bennett; J. Clin. Endocrinol. Metab. 90, 3534 (2005) Abstract; Full Text

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