ALEXIS Biochemicals: Gö 6976

ALX-270-021

Revised 03-Jul-08

Gö 6976
SYNONYMS	12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PKC Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-021-MC05		0.5 mg	160.00 USD

Product Specification

FORMULA:	C₂₄H₁₈N₄O
MW:	378.4
CAS NUMBER:	136194-77-9
PURITY:	≥95% (HPLC)
APPEARANCE:	Off-white to yellow solid.
SOLUBILITY:	Soluble in DMSO (25mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for at least 3-4 months when stored at -20°C.
HANDLING:	Protect from light.

Product Description

Very potent protein kinase C (PKC) inhibitor with high selectivity for the PKC isotypes (α, β and γ). Potent antagonist of HIV-1 induction.

Product Specific Literature References

Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C: J. Kleinschroth, et al.; Bioorg. Med. Chem. Lett 3, 1959 (1993)
Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976: G. Martiny-Baron, et al.; J. Biol. Chem. 268, 9194 (1993) Abstract; Full Text
Go 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low- level-producing reservoir cells in vitro: K.O. Qatsha, et al.; PNAS 90, 4674 (1993) Abstract
N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions: K. Wenzel-Seifert, et al.; BBRC 200, 1536 (1994) Abstract
Atypical isoforms of pKc and insulin secretion from pancreatic beta- cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors: T.E. Harris, et al.; BBRC 227, 672 (1996) Abstract

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