ALEXIS Biochemicals: Ghrelin (rat)

ALX-157-022

Revised 25-Sep-06

Ghrelin (rat)
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Ghrelin/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-157-022-MC05		0.5 mg	230.00 USD
ALX-157-022-M001		1 mg	390.00 USD

Product Specification

SEQUENCE:	H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
FORMULA:	C₁₄₇H₂₄₄N₄₅O₄₂
MW:	3313.8
CAS NUMBER:	258338-12-4
PURITY:	≥98%
FORMULATION:	Lyophilized.
SOLUBILITY:	Soluble in 5% acetic acid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Recent studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on th cardiovascular and immune system.

Product Specific Literature References

Ghrelin is a growth-hormone-releasing acylated peptide from stomach: M. Kojima, et al.; Nature 402, 656 (1999) Abstract
Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation: C. Dieguez & F.F. Casanueva; Eur. J. Endocrinol. 142, 413 (2000) Abstract; Full Text
(Ghrelin and immunity: a young player in an old field: V.D. Dixit & D.D. Taub; Exp. Gerontol. 40, 900 (2005), (Review) Abstract
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review) Abstract
Developments in ghrelin biology and potential clinical relevance: R.G. Smith, et al.; Trends Endocrinol. Metab. 16, 436 (2005), (Review) Abstract

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