ALEXIS Biochemicals: Glibenclamide

ALX-550-270

Revised 22-May-07

Glibenclamide
SYNONYMS	Glyburide
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	K+ Channel Blockers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-270-G001		1 g	17.00 USD

Product Specification

FORMULA:	C₂₃H₂₈ClN₃O₅S
MW:	494.0
CAS NUMBER:	10238-21-8
MERCK INDEX:	14: 4478
RTECS:	YS4725200
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
USE/STABILITY:	Solutions are stable for up to 3 months when stored at -20°C.
HAZARD:	HARMFUL.

Product Description

ATP-dependent K⁺ channel blocker in the pancreas, which in turn causes intracellular Ca²⁺ levels to rise and for insulin to be secreted. Antidiabetic. High affinity binding sites have been identified in the cardiovascular system, the CNS, and pancreatic beta cells. Large potency differences are observed between pancreatic tissue and vascular tissue.

Product Specific Literature References

Glipizide: a review of its pharmacological properties and therapeutic use: R.N. Brogden, et al.; Drugs 18, 329 (1979) Abstract
Intracellular ATP directly blocks K+ channels in pancreatic B-cells: D.L. Cook & C.N. Hales; Nature 311, 271 (1984) Abstract
Antidiabetic sulfonylureas control action potential properties in heart cells via high affinity receptors that are linked to ATP-dependent K+ channels: M. Fosset, et al.; J. Biol. Chem. 263, 7933 (1988) Abstract; Full Text
In vitro effects of sulfonylurea on glucose transport and translocation of glucose transporters in adipocytes from streptozocin-induced diabetic rats: D.R. Jacobs, et al.; Diabetes 38, 205 (1989) Abstract
Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle: R.J. Winquist, et al.; J. Pharmacol. Exp. Ther. 248, 149 (1989) Abstract
Potassium channel modulators: scientific applications and therapeutic promise: D.W. Robertson & M.I. Steinberg; J. Med. Chem. 33, 1529 (1990) Abstract
D.R. Gehlert, et al.; J. Pharmacol. Exp. Ther. 257, 901 (1991) Abstract
High affinity [3H]glibenclamide binding sites in rat neuronal and cardiac tissue: localization and developmental characteristics: J.A. Miller, et al.; J. Pharmacol. Exp. Ther. 256, 358 (1991) Abstract
Glyburide and tolbutamide induce desensitization of insulin release in rat pancreatic islets by different mechanisms: A.M. Rabuazzo, et al.; Endocrinology 131, 1815 (1992) Abstract

Further Categories Containing This Product:

Ca2+ Modulators • Antidiabetic Agents / Related Products

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.