ALEXIS Biochemicals: Granzyme A (human)

ALX-200-605

Revised 23-Apr-05

Granzyme A (human)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Granzymes

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-200-605-C010		10 µg	460.00 USD

Product Specification

MW:	~52kDa (fully glycosylated homodimer)
EC:	3.4.21.78
SOURCE/HOST:	Human cytotoxic granules of NK-92 cells.
CONCENTRATION:	2.76mg/ml
PURITY DETAIL:	Purified by differential solubilization and cation exchange chromatography. Dialyzed against 0.15M sodium chloride and concentrated.
FORMULATION:	Liquid. In ~0.15M sodium chloride.
SPECIFIC ACTIVITY:	~9.2U/µg protein. One unit is defined as the amount of enzyme that hydrolyzes 1nmole of Z-Lys-SBzl per min. at 25°C in 0.05M TRIS, pH 8.0, containing 0.15M NaCl, 0.01% Triton X-100, 0.3mM DTNB.
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Stable for at least 6 months when stored at -80°C. Do not store dilute solutions (1-1000ng/ml) for more than 24 hours.
HANDLING:	Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -80°C.

Product Specific Literature References

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis: D. Martinvalet, et al.; Immunity 22, 355 (2005) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P12544: Granzyme A (human) (precursor)

Further Categories Containing This Product:

Enzymes • Natural Proteins

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