ALEXIS Biochemicals: Granzyme B (human) (recombinant)

ALX-201-112

Revised 18-Mar-08

Granzyme B (human) (recombinant)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Granzymes

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-112-C010		10 µg	310.00 USD

Product Specification

MW:	~25.5kDa.
EC:	3.4.21.79
SOURCE/HOST:	Produced in E. coli. Active human granzyme B.
CONCENTRATION:	0.2mg/ml
FORMULATION:	Liquid. In PBS containing 10% glycerol. Contains no preservatives.
SPECIFIC ACTIVITY:	≥7.0U/µg protein. One unit is defined as the amount of enzyme that hydrolyzes 1nmol Ac-IEPD-pNA (Prod. No. ALX-260-152) per min. at 25°C in 0.05M TRIS, pH 8.0, containing 0.15M NaCl and 0.01% Triton X-100.
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Dilute solutions (e. g. 1-1000ng/ml) should be used within 24 hours.
HANDLING:	For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.

Product Specific Literature References

Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue: E. Estebanez-Perpina, et al.; Biol. Chem. 381, 1203 (2000) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P10144: Granzyme B (human) (precursor)

General Literature References

Definition and redesign of the extended substrate specificity of granzyme B : J.L. Harris, et al.; J. Biol. Chem. 273, 27364 (1998) Abstract; Full Text
Generation of catalytically active granzyme K from Escherichia coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma : E. Wilharm, et al.; J. Biol. Chem. 274, 27331 (1999) Abstract; Full Text

Further Categories Containing This Product:

Enzymes • Recombinant Proteins / Fusion Proteins

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