ALEXIS Biochemicals: Guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt

ALX-480-072

Revised 16-Jun-06

Guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . sodium salt
SYNONYMS	Rp-cGMPS . Na cGMPS . Na, Rp-Isomer
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	cGMP Derivatives

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-072-M001		1 mg	240.00 USD

Product Specification

FORMULA:	C₁₀H₁₁N₅O₆SP . Na
MW:	360.3 . 23.0
CAS NUMBER:	86562-09-6 (free acid)
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Inhibitor of cGMP-dependent protein kinase (PKG) 1α (cGMP antagonist). Resistant against mammalian cyclic nucleotid-dependent phosphodiesterases. No metabolic side effects. Low membrane permeability.

Product Specific Literature References

Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates: E. Butt, et al.; FEBS Lett. 263, 47 (1990) Abstract
Inhibition of cyclic GMP-dependent protein kinase-mediated effects by (Rp)-8-bromo-PET-cyclic GMPS: E. Butt, et al.; Br. J. Pharmacol. 116, 3110 (1995) Abstract

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