ALEXIS Biochemicals: HA14-1

ALX-430-101

Revised 08-Aug-08

HA14-1
SYNONYMS	Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Bcl-2 Family Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-101-M005		5 mg	40.00 USD
ALX-430-101-M025		25 mg	160.00 USD

Product Specification

FORMULA:	C₁₇H₁₇N₂O₅Br
MW:	409.2
CAS NUMBER:	65673-63-4
PURITY:	≥95% (¹H-NMR)
APPEARANCE:	Off-white to light yellow powder.
SOLUBILITY:	Soluble in DMSO, dimethyl formamide or halogenated solvents; also soluble in 100% ethanol (hot).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Unstable in solution. Prepare fresh solution for each application.
HANDLING:	Keep cool and dry.
IDENTITY:	Identity determined by IR, ¹H-NMR.

Product Description

Cell permeable Bcl-2 ligand.

Product Specific Literature References

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells: J.L. Wang, et al.; PNAS 97, 7124 (2000) Abstract
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis: D. Liu & Z. Huang; Apoptosis 6, 453 (2001) Abstract
Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia: M. Milella, et al.; Blood 99, 3461 (2002) Abstract

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