ALEXIS Biochemicals: HC Toxin

ALX-630-102

Revised 05-Apr-08

HC Toxin
SYNONYMS	Cyclo-(D-Pro-L-Ala-D-Ala-L-2-amino-8-oxo-9,10-epoxydecanoic acid)
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Toxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-630-102-M001		1 mg	195.00 USD

Product Specification

FORMULA:	C₂₁H₃₂N₄O₆
MW:	436.5
CAS NUMBER:	83209-65-8
SOURCE/HOST:	Isolated from Helminthosporium carbonium.
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable as supplied for up to 1 year. Stock solutions are stable for up to 3 months when stored at -20°C
HAZARD:	TOXIC.

Product Description

Potent, cell permeable, non-competitive and reversible inhibitor of histone deacetylase (HDAC) (IC₅₀=30nM). Does not inhibit histone acetyltransferases. Induces expression of γ-globulin in erythroid cells. Shows anti-mitogenic activities. Induces cell cycle arrest and apoptosis in tumor cells.

Product Specific Literature References

The structure and conformation of HC-toxin: M. Kawai, et al.; Biochem. Biophys. Res. Commun. 111, 398 (1983) Abstract
Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum: G. Brosch, et al.; Plant Cell 7, 1941 (1995) Abstract
Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells: K.N. Min, et al.; Arch. Pharm. Res. 27, 554 (2004) Abstract
Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells: K.E. Joung, et al.; Arch. Pharm. Res. 27, 640 (2004) Abstract

Further Categories Containing This Product:

HDAC Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products for Cell Cycle Research

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