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ALX-522-017 Revised 24-Mar-05
HVEM (human):Fc (human) (recombinant)
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SYNONYMS Herpesvirus Entry Mediator A (human):Fc (human) (recombinant)
ATAR (human):Fc (human) (recombinant)
LIGHT-R (human):Fc (human) (recombinant)
TR2 (human):Fc (human) (recombinant)
TNFRSF 14 (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY HVEM & LIGHT/LT-betaR/DcR3/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-017-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~58kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human HVEM (aa 39-200) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml, after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds human and mouse LIGHT. 
BIOLOGICAL ACTIVITY: Inhibits LIGHT-mediated effects such as the cytotoxic effect on HT29 target cells. Prevents Herpes Simplex Virus-1 infection of T-cells.
APPLICATION: Detection of membrane-bound human and mouse LIGHT (HVEML) in combination with PAb to human IgG1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
HVEM (TR2, ATAR, HVEA) is a 36 kDa type I transmembrane protein belonging to the TNF receptor family. HVEM contains 3 cysteine-rich repeats in the extracellular portion which is typical of TNFR family members. HVEM mediates Herpes Simplex Virus-1 infection of T cells. Ligation of HVEM by its cellular trimeric ligand LIGHT (Prod. No. ALX-522-018) induces recruitment to the cytoplasmic domain of the signaling molecules TRAF2 and 5. Activation in vitro of HVEM leads to induction of nuclear factors NFκB and AP-1. The outcome of HVEM activation on T cells is still controversial. A second ligand for HVEM is soluble LTα.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q92956: HVEM (human) (precursor)
AfCS Signalling Gateway link A001150: HVEM (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
 
 
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