ALEXIS Biochemicals: Hellebrin

ALX-350-105

Revised 05-Apr-08

Hellebrin
SYNONYMS	3β-(O4-β-D-Glucopyranosyl-α-L-rhamnopyranosyloxy)-5,14-dihydroxy-19-oxo-5β,14-β-bufa-20,22-dienolide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - ATPase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-105-M001		1 mg	45.00 USD
ALX-350-105-M005		5 mg	180.00 USD

Product Specification

FORMULA:	C₃₆H₅₂O₁₅
MW:	724.8
CAS NUMBER:	13289-18-4
SOURCE/HOST:	Isolated from Helleborus sp.
PURITY:	≥99%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC.

Product Description

Cardiotonic glycoside which presents a bufadienolide-steroid structure. Besides ouabain (Prod. No. ALX-350-066), from the class of cardenolides hellebrin is the second unique water soluble cardiotonic glycoside. Extremely potent inhibitor of Na⁺/K⁺-ATPase (sodium pump) blocking the active efflux of Na⁺ and reuptake of K⁺ of this membrane enzyme. Shows a positive inotropic effect by increasing the intracellular Ca²⁺ concentration. Strong immunosuppressor inhibiting T cell activity with much higher potency than cortisol or cyclosporin A (Prod. No. ALX-380-002). Induces caspase-dependent apoptosis.

Product Specific Literature References

Über Hellebrin, ein krystallisiertes Glykosid aus Radix Hellebori nigri: W. Karrer; Helv. Chim. Acta 26, 1353 (1943)
The structure of hellebrin: P. Muhr, et al.; Liebigs Ann. Org. Bioorg. Chem. 2, 443 (1995)
In search of ideal inotropic steroids: recent progress: K.R. Repke, et al.; Prog. Drug Res. 47, 9 (1996) Abstract
Exquisitely small amounts of nonglucocorticoid natural steroids suppress the human allogeneic T-cell response: P. Terness, et al.; Transplant Proc. 33, 547 (2001) Abstract
Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives: D. Daniel, et al.; Int. Immunopharmacol. 3, 1791 (2003) Abstract

Further Categories Containing This Product:

Na+ / K+-ATPase / Related Products • Calcium Signalling (Intracellular) Other Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Immunomodulators

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