ALEXIS Biochemicals: Hexaprenylhydroquinone

ALX-350-138

Revised 05-Dec-06

Hexaprenylhydroquinone
SYNONYMS	HPH
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antiviral / anti-HIV Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-138-M001		1 mg	160.00 USD

Product Specification

FORMULA:	C₃₆H₅₄O₂
MW:	518.8
CAS NUMBER:	119980-00-6
SOURCE/HOST:	Isolated from Sarcotragus sp.
PURITY:	≥97% (HPLC)
APPEARANCE:	Off-white to brown solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
IDENTITY:	Identity determined by MS, ¹H-NMR.

Product Description

Potent inhibitor of HIV reverse transcriptase and cellular DNA polymerase. Inhibitor of CDC25A. Similar compounds have shown inhibitory effects on phospholipase A2.

Product Specific Literature References

Three new heptaprenylhydroquinone derivatives from the sponge Ircinia fasciculata: Y. Venkateswarlu and M. Venkata Rami Reddy; J. Nat. Prod. 57, 1286 (1994)
Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays: S. De Rosa, et al.; J. Nat. Prod. 57, 1711 (1994) Abstract
Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases: S. Loya, et al.; Biochem. J. 324, 721 (1997) Abstract; Full Text
Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A: I. Erdogan-Orhan, et al.; Nat. Prod. Res. 18, 1 (2004) Abstract

General Literature References

Effects of marine 2-polyprenyl-1,4-hydroquinones on phospholipase A2 activity and some inflammatory responses: B. Gil, et al.; Eur. J. Pharmacol. 285, 281 (1995) Abstract

Further Categories Containing This Product:

PLA2 Inhibitors • Natural Products - DNA Replication Inhibitors • HIV / AIDS / Related Products

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