ALEXIS Biochemicals: IL-1F8 (human) (recombinant)

ALX-522-129

Revised 27-Mar-08

IL-1F8 (human) (recombinant)
SYNONYMS	Interleukin-1 Family Member 8 (human) (recombinant) IL-1η (human) (recombinant) Interleukin-1η (human) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	Interleukins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-129-C050		50 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
MW:	~16kDa (SDS-PAGE)
SOURCE/HOST:	Produced in E. coli (aa 1-157).
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

General Information

IL-1F5, F6, F8 and F9 are new members of the family of IL-1 (IL-1α/β, IL-18, IL-33). IL-1F6, IL-1F8 and IL-1F9 activate the NF-κB and MAPK pathways through the IL-Rrp2 and IL-1RAcP receptor complex leading to the production of IL-6 and IL-8. Agonistic activation of the IL-1F6, F8 and F9 is counterbalanced by the inhibitory activity of IL-1F5. These interleukins are mainly expressed in skin keratinocytes and internal epithelial tissues exposed to pathogenic bacteria suggesting a role in immune signalling and inflammation. IL-F5, F6 and F9 as well as the receptor IL-1Rrp2 are increased in psoriasis.
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q9NZH7: Interleukin-1 Family Member 8 (human)
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs: J.E. Towne, et al.; J. Biol. Chem. 279, 13677 (2004) Abstract; Full Text

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Recombinant Proteins / Fusion Proteins

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