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ALX-522-098 Revised 27-Mar-08
IL-33 (human) (recombinant)
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SYNONYMS Interleukin-33 (human) (recombinant)
NF-HEV (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-098-C010   10 µg 190.00 USD Add To Cart
ALX-522-098-3010 SuperPack 3x10 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~18kDa
SOURCE/HOST: Produced in E. coli. Untagged human IL-33 (aa 112-270).
CONCENTRATION: 0.1mg/ml after reconstitution.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY: Binds to human ST2.
BIOLOGICAL ACTIVITY: Activates human ST2-dependent NF-κB pathway. Does not activate mouse ST2-dependent NF-κB.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Product Specific Literature References
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo: V. Carriere et al.; PNAS 104, 282 (2007) Abstract
General Information
IL-33 is a new member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1 R4) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-κB and MAPK pathways. The human IL-33 protein is expressed with a prodomain (aa 1-111) which is cleaved by caspase-1 to produce the 18kDa mature protein (112-270).
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q2YEJ5: Interleukin-33 (human)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines: J. Schmitz, et al.; Immunity 23, 479 (2005) Abstract
Related Products
Further Categories Containing This Product:
Interleukin-33 [IL-33] & Receptors / Related Products • Recombinant Proteins / Fusion Proteins
 
 
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