ALEXIS Biochemicals: INDO 1/AM

ALX-450-005

Revised 04-Feb-05

INDO 1/AM
SYNONYMS	1-[2-Amino-5-(6-carboxyindol-2-yl)phenoxy]-2-(2'-amino-5'-methylphenoxy)ethane-N,N,N',N'-tetraacetic acid, pentaacetoxymethylester
PRODUCT LINE	Other Products
PRODUCT CATEGORY	Dyes / Stains / Fluorescent Probes / Fluorescent Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-450-005-M001		1 mg	130.00 USD
ALX-450-005-M005		5 mg	520.00 USD

Product Specification

FORMULA:	C₄₇H₅₁N₃O₂₂
MW:	1009.9
CAS NUMBER:	112926-02-0
PURITY:	≥97%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Cell permeable analog of INDO 1 (Prod. No. ALX-450-004). Fluorescent probe for Ca²⁺. After crossing the membrane, the product is rapidly hydrolyzed by cytoplasmic esterases to the membrane impermeant INDO 1.

Product Specific Literature References

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures: R.Y. Tsien; Biochemistry 19, 2396 (1980) Abstract
A new generation of Ca2+ indicators with greatly improved fluorescence properties: G. Grynkiewicz, et al.; J. Biol. Chem. 260, 3440 (1985) Abstract; Full Text
Measuring cytosolic free calcium concentration in endothelial cells with indo-1: the pitfall of using the ratio of two fluorescence intensities recorded at different wavelengths: A. Luckhoff; Cell Calcium 7, 233 (1986) Abstract
Cross-linking of surface immunoglobulin on B lymphocytes induces both intracellular Ca2+ release and Ca2+ influx: analysis with indo-1: M.K. Bijsterbosch, et al.; BBRC 137, 500 (1986) Abstract
Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry: P.S. Rabinovitch, et al.; J. Immunol. 137, 952 (1986) Abstract
Cytosolic and vacuolar Ca2+ concentrations in yeast cells measured with the Ca2+-sensitive fluorescence dye indo-1: D. Halachmi & Y. Eilam; FEBS Lett. 256, 55 (1989) Abstract
Calcium mobilization in human platelets using indo-1 and flow cytometry: L.K. Jennings, et al.; Blood 74, 2674 (1989) Abstract
Analysis of cytosolic ionized calcium variation in polymorphonuclear leukocytes using flow cytometry and Indo-1 AM: M. Lopez, et al.; Cytometry 10, 165 (1989) Abstract
Intracellular Ca2+ measurement with Indo-1 in substrate-attached cells: advantages and special considerations: M. Wahl, et al.; Cell Calcium 11, 487 (1990) Abstract
Calcium homeostasis in dissociated embryonic neurons: a flow cytometric analysis: J.P. Grierson, et al.; J. Neurophysiol. 67, 704 (1992) Abstract

Further Categories Containing This Product:

Calcium Indicators / Probes • MDR Other Products • Calcium Chelators / Caged Calcium Chelators

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