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ALX-630-058 Revised 17-Jun-08
Iberiotoxin
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SYNONYMS IbTx
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-058-C100   100 µg 490.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH
(Disulfide bonds between Cys7-Cys28, Cys13-Cys33 and Cys17-Cys35)
FORMULA: C179H274N50O55S7
MW: 4230.9
CAS NUMBER: 129203-60-7
SOURCE/HOST: Synthetic. From Buthus tamulus.
QUANTITY: 0.11mg (26nmol)
CONCENTRATION: 0.1mM after reconstitution.
PURITY: ≥94% (HPLC)
FORMULATION: Lyophilized from aqueous acetic acid solution.
RECONSTITUTION: Do not remove the cap. Inject 260μl distilled water into the vial using a calibrated syringe. Dissolve the contents thouroughly.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: The undissolved peptide is stable at -20°C for more than 1 year. The aqueous solution should be used within a few weeks.
HANDLING: After reconstitution, prepare aliquots and store at -20°C.
HAZARD: VERY TOXIC.
Product Description
Potent and selective blocker of the high conductance Ca2+-activated K+ channels.
Product Specific Literature References
Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus: A. Galvez, et al.; J. Biol. Chem. 265, 11083 (1990) Abstract; Full Text
Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel
: S. Candia, et al.; Biophys. J. 63, 583 (1992) Abstract
Synthetic charybdotoxin-iberiotoxin chimeric peptides define toxin binding sites on calcium-activated and voltage-dependent potassium channels: K.M. Gianciacomo, et al.; Biochemistry 32, 2363 (1993) Abstract
Synthesis and biological characterisation of a series of iberiotoxin analogues: J.P. Flinn, et al.; Int. J. Pept. Protein Res. 45, 320 (1995) Abstract
Iberiotoxin-induced block of Ca2+-activated K+ channels induces dihydropyridine sensitivity of ACh release from mammalian motor nerve terminals: M. T. Flink & W. D. Atchison; J. Pharmacol. Exp. Ther. 305, 646 (2003) Abstract
Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels: Y. D. Gao & M. L. Garcia; Proteins 52, 146 (2003) Abstract
Description and role in proliferation of iberiotoxin-sensitive currents in different human mammary epithelial normal and cancerous cells: S. Roger, et al.; Biochim. Biophys. Acta 1667, 190 (2004) Abstract
Further Categories Containing This Product:
K+ Channel Blockers & Inhibitors • Peptides
 
 
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