ALEXIS Biochemicals: Imiquimod

ALX-420-039

Revised 14-Aug-08

Imiquimod
SYNONYMS	1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine R-837
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLR Agonists Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-039-M100		100 mg	55.00 USD
ALX-420-039-M250		250 mg	120.00 USD

Product Specification

FORMULA:	C₁₄H₁₆N₄
MW:	240.3
CAS NUMBER:	99011-02-6
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO (3mg/ml) or dimethyl formamide; slightly soluble in water (warm to 37°C, vortex); insoluble in 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C.

Product Description

Topical immune response modifier that inhibits angiogenesis. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.

Product Specific Literature References

Imiquimod applied topically: a novel immune response modifier and new class of drug: R.L. Miller, et al.; Int. J. Immunopharmacol. 21, 1 (1999) Abstract
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway: H. Hemmi, et al.; Nat. Immunol. 3, 196 (2002) Abstract
In vivo and in situ modulation of the expression of genes involved in metastasis and angiogenesis in a patient treated with topical imiquimod for melanoma skin metastases: C. Hesling, et al.; Br. J. Dermatol. 150, 761 (2004) Abstract
Imiquimod as an antiangiogenic agent: V.W. Li, et al.; J. Drugs Dermatol. 4, 708 (2005) Abstract
Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis: S. Majewski, et al.; Int. J. Dermatol. 44, 14 (2005) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Stimulation of TLR7 can be achieved with 1-10µg/ml of the compound for 6 to 24 hours.

Related Products:
- ddWater (endotoxin-free) (Prod. No. ALX-505-008)
- PBS (endotoxin-free) (Prod. No. ALX-505-007)

ALX-505-007	PBS (endotoxin-free)
ALX-505-008	ddWater (endotoxin-free)