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ALX-260-056
Revised 11-Dec-07
Ac-ESMD-CHO
SYNONYMS
Caspase-8 Inhibitor (Aldehyde)
Granzyme B Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-056-M001
1 mg
83.00 USD
ALX-260-056-M005
5 mg
325.00 USD
Product Specification
SEQUENCE:
Ac-Glu-Ser-Met-Asp-CHO
FORMULA:
C
19
H
30
N
4
O
10
S
MW:
506.5
PEPTIDE CONTENT:
70-90%.
PURITY:
≥99% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in distilled water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Use always fresh solutions.
HANDLING:
Keep cool and dry. Keep under inert gas.
Product Description
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-6 and -10. The peptide sequence corresponds to one of the cleavage sites of the inactive 32kDa caspase-3 precursor (aa 25-28). It blocks the formation of the p17 subunit and concomitantly induces the accumulation of the p20 peptide.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Granzyme Inhibitors
ALX-260-115
Revised 05-Apr-05
Ac-IEPD-AFC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-115-M005
5 mg
157.00 USD
ALX-260-115-M010
10 mg
295.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Pro-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
32
H
38
F
3
N
5
O
11
MW:
725.7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8 and granzyme B.
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-151
Revised 17-Jan-06
Ac-IEPD-AMC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-151-M001
1 mg
70.00 USD
ALX-260-151-M005
5 mg
210.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Pro-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
32
H
41
N
5
O
11
MW:
671.7
PEPTIDE CONTENT:
70-95%
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8 and granzyme B.
Product Specific Literature References
Definition and redesign of the extended substrate specificity of granzyme B:
J.L. Harris, et al.; J. Biol. Chem.
273
, 27364 (1998)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-152
Revised 05-Apr-05
Ac-IEPD-pNA
SYNONYMS
Caspase-8 Substrate (Chromogenic)
Granzyme B Substrate (Chromogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-152-M001
1 mg
60.00 USD
ALX-260-152-M005
5 mg
180.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Pro-Asp-pNA (pNA=p-Nitroaniline)
FORMULA:
C
28
H
38
N
6
O
11
MW:
634.6
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Chromogenic substrate for caspase-8 and granzyme B.
Product Specific Literature References
Definition and redesign of the extended substrate specificity of granzyme B:
J.L. Harris, et al.; J. Biol. Chem.
273
, 27364 (1998)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
λmax of pNA is 400nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-110
Revised 05-Apr-05
Ac-IETD-AFC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-110-M005
5 mg
157.00 USD
ALX-260-110-M010
10 mg
295.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:
C
31
H
38
F
3
N
5
O
12
MW:
729.7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy:
D.J. Granville, et al.; FEBS Lett.
437
, 5 (1998)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AFC has an excitation maximum of 400nm and an emission maximum of 505nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-042
Revised 02-Oct-07
Ac-IETD-AMC
SYNONYMS
Caspase-8 Substrate (Fluorogenic)
Granzyme B Substrate (Fluorogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-042-M001
1 mg
42.00 USD
ALX-260-042-M005
5 mg
163.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:
C
31
H
41
N
5
O
12
MW:
675.7
PEPTIDE CONTENT:
70-90%
PURITY:
≥98% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Fluorogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor
:
N.A. Maianski, et al.; J. Immunol.
172
, 7024 (2004)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-043
Revised 13-Nov-06
Ac-IETD-CHO
SYNONYMS
Caspase-8 Inhibitor (Aldehyde)
Granzyme B Inhibitor (Aldehyde)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-043-M001
1 mg
62.00 USD
ALX-260-043-M005
5 mg
243.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-CHO
FORMULA:
C
21
H
34
N
4
O
10
MW:
502.5
PEPTIDE CONTENT:
70-90%.
PURITY:
≥97% (HPLC)
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Use always fresh solutions.
HANDLING:
Keep cool and dry.
Product Description
Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-10.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
Granzyme Inhibitors
ALX-260-045
Revised 15-Dec-05
Ac-IETD-pNA
SYNONYMS
Caspase-8 Substrate (Chromogenic)
Granzyme B Substrate (Chromogenic)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-045-M001
1 mg
22.00 USD
ALX-260-045-M005
5 mg
83.00 USD
Product Specification
SEQUENCE:
Ac-Ile-Glu-Thr-Asp-pNA (pNA=p-Nitroaniline)
FORMULA:
C
27
H
38
N
6
O
12
MW:
638.6
PEPTIDE CONTENT:
70-90%
PURITY:
98% (HPLC)
APPEARANCE:
White powder.
FORMULATION:
Lyophilized.
SOLUBILITY:
Soluble in DMSO. Dilute with buffer, pH 7.0-7.5.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Keep cool and dry.
Product Description
Chromogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10.
Product Specific Literature References
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro:
Z. Han, et al.; J. Biol. Chem.
272
, 13432 (1997)
Abstract
;
Full Text
Apoptosome-independent pathway for apoptosis. Biochemical analysis of APAF-1 defects and biological outcomes:
C.A. Belmokhtar, et al.; J. Biol. Chem.
278
, 29571 (2003)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
λmax of pNA is 400nm.
Further Categories Containing This Product:
Granzyme Substrates
ALX-260-050
Revised 18-Jan-05
BAADT
SYNONYMS
Granzyme B Substrate (Chromogenic)
Boc-AAD-SBzl
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Substrates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-260-050-M001
1 mg
110.00 USD
ALX-260-050-M005
5 mg
410.00 USD
Product Specification
SEQUENCE:
Boc-Ala-Ala-Asp-SBzl
FORMULA:
C
22
H
31
N
3
O
7
S
MW:
481.6
PURITY:
≥96% (HPLC).
Single spot (TLC)
APPEARANCE:
White to off-white crystalline powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Very hygroscopic.
Product Description
Chromogenic substrate for granzyme B. λmax is at 405nm.
Product Specific Literature References
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins:
S. Odake, et al.; Biochemistry
30
, 2217 (1991)
Abstract
Further Categories Containing This Product:
Granzyme Substrates
ALX-748-015
Revised 24-Mar-05
Fas (human) cDNA Probe
SYNONYMS
CD95 (human) cDNA Probe
APO-1 (human) cDNA Probe
TNFRSF 6 (human) cDNA Probe
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Fas cDNA Probes
Ordering Information
Product Numbers:
Format:
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ALX-748-015-C001
1 µg
140.00 USD
Product Specification
SOURCE/HOST:
Derived from the coding region of the human Fas (CD95) gene. Has a length of ~500bp located within the region between nucleotides 500-1000.
CONCENTRATION:
0.1mg/ml after reconstitution.
PURITY:
≥95% (agarose gel electrophoresis)
FORMULATION:
Lyophilized powder.
RECONSTITUTION:
Reconstitute with 10µl sterile water or 10mM Tris . HCl containing 0.1mM Na
2
EDTA.
APPLICATION:
Northern Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
DNA & RNA Probes / Related Products
ALX-522-002
Revised 06-Jun-07
Fas (human):Fc (human) (recombinant)
SYNONYMS
APO-1 (human):Fc (human) (recombinant)
CD95 (human):Fc (human) (recombinant)
TNFRSF 6 (human):Fc (human) (recombinant)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Fas
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-522-002-C050
50 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
Produced in HEK 293 cells. The extracellular domain of human Fas (CD95; APO-1) (aa 7-154) is fused to the Fc portion of human IgG1.
CONCENTRATION:
1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 50µl sterile water. Further dilutions can be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY:
Binds human, mouse and rat FasL (AP
