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Immunology
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 Items 180-200 of 2042 Page 10 of 103 Select Page: << 6 7 8 9 10 11 12 13 14 15  >>  
ALX-380-241 Revised 21-May-08
Blasticidin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-241-M001   1 mg 370.00 USD Add To Cart
Product Specification
FORMULA: C58H107NO23
MW: 1186.5 (free acid)
CAS NUMBER: 100513-53-9
RTECS: EC4897000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS4079.
PURITY: ≥98% (HPLC)
APPEARANCE:

Yellow tan solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or methanol; fairly soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Antibiotic. Shows broad spectrum antifungal and antibacterial activity. Specific inhibitor of aflatoxin production by Aspergillus parasiticus.
Product Specific Literature References
Blasticidin, a new anti-phytopathogenic fungal substance: K. Fukunaga, et al.; Bull. Agr. Chem. Soc. Jpn. 19, 181 (1955)
Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus: S. Sakuda, et al.; J. Antibiot. 53, 1265 (2000) Abstract
Further Categories Containing This Product:
Natural Products - Antifungal Agents • Natural Products with Antibiotic Activity
 
 
ALX-380-089 Revised 29-Jul-08
Blasticidin S . hydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - DNA Replication Inhibitors
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ALX-380-089-M100   100 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C17H26N8O5 . HCl
MW: 422.4 . 36.5
CAS NUMBER: 3513-03-9
MERCK INDEX: 14: 1316
SOURCE/HOST: Isolated from Streptomyces griseochromogenes.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water; insoluble in organic solvents.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.
HAZARD: VERY TOXIC.

Product Description
Antibiotic. Inhibitor of DNA and protein synthesis.
Product Specific Literature References
Blasticidin S, a new antibiotic: S. Takeuchi, et al.; J. Antibiot. (Tokyo) 11, 1 (1958) Abstract
The blasticidin S resistance gene (bsr) selectable in a single copy state in the Bacillus subtilis chromosome: M. Itaya, et al.; J. Biochem. 107, 799 (1990) Abstract
Cloning and characterization of the gene encoding a blasticidin S acetyltransferase from Streptoverticillum sp: J.A. Perez-Gonzalez, et al.; Gene 86, 129 (1990) Abstract
Blasticidin S-resistance gene (bsr): a novel selectable marker for mammalian cells: M. Izumi, et al.; Exp. Cell Res. 197, 229 (1991) Abstract
Cloning of the blasticidin S deaminase gene (BSD) from Aspergillus terreus and its use as a selectable marker for Schizosaccharomyces pombe and Pyricularia oryzae: M. Kimura, et al.; Mol. Gen. Genet. 242, 121 (1994) Abstract
Blasticidin S deaminase gene from Aspergillus terreus (BSD): a new drug resistance gene for transfection of mammalian cells: M. Kimura, et al.; Biochim. Biophys. Acta 1219, 653 (1994) Abstract
Further Categories Containing This Product:
Reporter Gene Markers / Related Products • Translation Inhibitors • Antibiotics - Antifungal • DNA Replication Inhibitors
 
 
ALX-630-107 Revised 21-Feb-08
Bleomycin . sulfate
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SYNONYMS Blenoxane
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-107-M010   10 mg 155.00 USD Add To Cart
ALX-630-107-M050   50 mg 595.00 USD Add To Cart
Product Specification
FORMULA: C55H82N17O21S3 . H2SO4
MW: 1413.6 . 98.1
CAS NUMBER: 9041-93-4
MERCK INDEX: 14: 1318
RTECS: EC5991990
SOURCE/HOST: A group of related glycopeptide antibiotics isolated from Streptomyces verticillus.
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (20mg/ml) or methanol.
ACTIVITY: 1'500-2'000 IU/mg
(corresponds to 1.5-2.0 bleomycin units (USP)/mg)
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Solutions in normal saline (~2mg/ml) are stable for 3 months when stored at +4°C in a glass container or stable for 1 month when stored at +4°C in a PVC container. Solutions in water are stable for several days only.
HAZARD: MAY BE CARCINOGENIC. TOXIC.

Product Description

Radiomimetic DNA-cleaving agent that produces double and single DNA strand breaks through an oxygen-radical-dependent mechanism. Inhibits intracellular DNA replication. DNA alkylating agent. Antineoplastic.
Product Specific Literature References
Bleomycin and other antitumor antibiotics of high molecular weight: H. Umezawa; Antimicrobial Agents Chemother. (Bethesda) 5, 1079 (1965) Abstract
Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin: J. Kross, et al.; Biochemistry 21, 4310 (1982) Abstract
Chromatin structure during bleomycin-induced DNA damage and repair
: B.P. Cuiffo, et al.; J. Free Radic. Biol. Med. 1, 139 (1985) Abstract
Cleavage of tRNA by Fe(II)-bleomycin: A. Huttenhofer, et al.; J. Biol. Chem. 267, 24471 (1992) Abstract
Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models: M. Schirner, et al.; Clin. Cancer Res. 4, 1331 (1998) Abstract
Sequence-specific changes in the metal site of ferric bleomycin induced by the binding of DNA: J.W. Sam, et al.; J. Biol. Chem. 273, 16090 (1998) Abstract
Changes in c-Jun but not Bcl-2 family proteins in p53-dependent apoptosis of mouse cerebellar granule neurons induced by DNA damaging agent bleomycin: T. Araki, et al.; Brain Res. 794, 239 (1998) Abstract
Induction of apoptosis by bleomycin in resting and cycling human lymphocytes: P. Vernole, et al.; Mutagenesis 13, 209 (1998) Abstract
Synergistic Effects of Laserthermia and Bleomycin-sulfate on Micronuclei Formation in Cytokinesis-blocked HeLa Cells: A.Sh. Monfared & H. Mozdarani; Irn. J. Med. Sci. 24, 87 (1999)
Bleomycin: new perspectives on the mechanism of action: S.M. Hecht; J. Nat. Prod. 63, 158 (2000), (Review) Abstract
Bleomycin-induced alterations in DNA replication: relationship to DNA damage: J. Dziegielewski, et al.; Biochemistry 40, 704 (2001) Abstract
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • DNA Fragmentation & Chromatin Condensation
 
 
ALX-155-028 Revised 11-Nov-05
Blocking Peptide for MAb to Estrogen Receptor α (Prod. No. ALX-803-004)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Blocking Peptides
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ALX-155-028-C050   50 µg 132.00 USD Add To Cart
Product Specification
SEQUENCE: E247VGMMKGGIRKDRRG261.
FORMULA: C68H124N26O20S2
MW: 1690.0
PURITY: ≥95%
FORMULATION: Lyophilized synthetic peptide.
RECONSTITUTION: Reconstitute with 0.1ml of distilled water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Synthetic peptide corresponding to aa 247-261 of the ER-DNA binding domain of human estrogen receptor α (ERα).
 
 
ALX-163-009 Revised 24-Feb-06
Blocking Peptide for MAb to NF-ATc2 (Prod. No. ALX-804-215)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Blocking Peptides
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ALX-163-009-C050   50 µg 132.00 USD Add To Cart
Product Specification
SEQUENCE: A51ISSPSGLAYPDDVLDYGL69.
MW: 1953.1
PURITY: ≥95%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Synthetic peptide corresponding to aa 51-69 of mouse nuclear factor of activated T cells, cytoplasmic 2 (NFAT1). The sequence is conserved in all three isoforms A, B, and C.
General Information
BACKGROUND/TECHNICAL INFORMATION Note: Confusion may arise regarding NFAT protein versus gene names.
According to Swiss-Prot, the nomenclature is as follows:
Nuclear Factor of Activated T Cells, Cytoplasmic 1 (NF-ATc1)
Gene Names: NFATC1 or NFATC or NFAT2
Nuclear Factor of Activated T Cells, Cytoplasmic 2 (NF-ATc2)
Gene Names: NFATC2 or NFATP or NFAT1
Nuclear Factor of Activated T Cells, Cytoplasmic 3 (NF-ATc3)
Gene Names: NFATC3 or NFATX or NFAT4
Nuclear Factor of Activated T Cells, Cytoplasmic 4 (NF-ATc4)
Gene Names: NFATC4 or NFAT3
Nuclear Factor of Activated T Cells (NF-AT5)
Gene Names: NFAT5
 
 
ALX-165-046 Revised 18-May-04
Blocking Peptide for MAb to Prion Protein (Prod. No. ALX-803-042)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Blocking Peptides
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ALX-165-046-C050   50 µg 132.00 USD Add To Cart
Product Specification
SEQUENCE: S146RPLIHFGSDYEDR159.
MW: 1691.8
PURITY: ≥95%
FORMULATION: Lyophilized synthetic peptide.
RECONSTITUTION: Reconstitute with 0.1ml of distilled water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Description
Synthetic peptide corresponding to aa 146-159 of bovine prion protein.
Use peptide for neutralization and control experiments with monoclonal antibody that reacts with this product and bovine prion protein (Prod. No. ALX-803-042). Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition antibody-protein binding reactions.
 
 
ALX-165-027 Revised 11-Nov-05
Blocking Peptide for MAb to Progesterone Receptor (Prod. No. ALX-803-007)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Blocking Peptides
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ALX-165-027-C050   50 µg 132.00 USD Add To Cart
Product Specification
SEQUENCE: G533LPQVYPPYLNYLRP547.
FORMULA: C87H128N20O21
MW: 1790.1
PURITY: ≥95%
FORMULATION: Lyophilized synthetic peptide.
RECONSTITUTION: Reconstitute with 0.1ml of distilled water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Synthetic peptide corresponding to aa 533-547 of human progesterone receptor (PR) DNA binding domain.
 
 
ALX-166-004 Revised 13-Dec-04
Blocking Peptide for PAb (Prod. No. ALX-210-157) & MAb (Prod. No. ALX-804-103) to Retinoic Acid Receptor
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PRODUCT LINE Immunology
PRODUCT CATEGORY Blocking Peptides
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ALX-166-004-C050   50 µg 132.00 USD Add To Cart
Product Specification
SEQUENCE: CP463SVSPSSVENSGVSQSPLLQ482.
FORMULA: C87H144N24O34S
MW: 2102.3
PURITY: ≥95%
FORMULATION: Lyophilized synthetic peptide.
RECONSTITUTION: Reconstitute with 0.1ml of distilled water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Synthetic peptide corresponding to aa 463-482 of mouse retinoic acid receptor β with an added N-terminal cysteine.
 
 
ALX-167-019 Revised 28-Sep-04
Blocking Peptide for MAb to SMRT (human) (Prod. No. ALX-804-281 & ALX-804-282)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Blocking Peptides
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ALX-167-019-C050   50 µg 132.00 USD Add To Cart
Product Specification
SEQUENCE: CGGA994SASDPHREKTQ1005.
MW: 1543.6
PURITY: ≥95%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
Synthetic peptide corresponding to aa 994-1005 of human SMRT with an added N-terminal CGG-sequence.
 
 
ALX-151-044 Revised 12-Oct-07
Blocking Peptide for PAb Adiponectin Receptor 1 (human) (Prod. No. ALX-210-644)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Blocking Peptides
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ALX-151-044-C100   100 µg 95.00 USD Add To Cart
Product Specification
SEQUENCE: S2SHKGSVVAQGNGAPASNREADTVE26
CONCENTRATION: 3.5mg/ml
PURITY: ≥90% (HPLC)
FORMULATION: Liquid. In 20mM acetate buffer, pH 4.5.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Some of the peptide may precipitate upon thawing. Resuspend by sonification and dilute with appropriate buffer to dissolve if necessary.
Product Description
Synthetic peptide corresponding to aa 2-26 of human adiponectin receptor 1 (AdipoR1).
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ALX-151-046 Revised 12-Oct-07
Blocking Peptide for PAb to Adiponectin Receptor 2 (human) (Prod. No. ALX-210-646)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Blocking Peptides
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ALX-151-046-C100   100 µg 95.00 USD Add To Cart
Product Specification
SEQUENCE: C11SRTPEPDIRLRKGHQLDGTRRGDNDSHQG40
CONCENTRATION: 3.5mg/ml
PURITY: ≥90% (HPLC)
FORMULATION: Liquid. In 20mM acetate buffer, pH 4.5.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Some of the peptide may precipitate upon thawing. Resuspend by sonification and dilute with appropriate buffer to dissolve if necessary.
Product Description
Synthetic peptide corresponding to aa 11-40 of human adiponectin receptor 2 (AdipoR2).
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ALX-151-045 Revised 25-Sep-07
Blocking Peptide for PAb to Adiponectin Receptor 1 (Prod. No. ALX-210-645)
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PRODUCT LINE Immunology
PRODUCT CATEGORY Blocking Peptides
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ALX-151-045-C100   100 µg 95.00 USD Add To Cart
Product Specification
SEQUENCE: V345AAAFVHFYGVSNLQEFRYGLEGGC369
CONCENTRATION: 3.5mg/ml
PURITY: ≥90% (HPLC)
FORMULATION: Liquid. In 20mM acetate buffer, pH 4.5.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Some of the peptide may precipitate upon thawing. Resuspend by sonification and dilute with appropriate buffer to dissolve if necessary.
Product Description

Synthetic peptide corresponding to aa 345-369 of human, mouse or rat adiponectin receptor 1 (AdipoR1).
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