ALEXIS Biochemicals: Indirubin-5-sulfonic acid . sodium salt

ALX-270-296

Revised 17-Jul-07

Indirubin-5-sulfonic acid . sodium salt
SYNONYMS	E226 Indirubin-5-sulphonate . Na
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDK & Cyclin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-296-M001		1 mg	45.00 USD
ALX-270-296-M005		5 mg	180.00 USD

Product Specification

FORMULA:	C₁₆H₉N₂O₅S . Na
MW:	341.3 . 23.0
PURITY:	≥98% (¹H-NMR)
APPEARANCE:	Black powder.
SOLUBILITY:	Soluble in DMSO or water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inhibitor of cyclin-dependent kinases (CDKs), with selectivity for CDK1/cyclin B (IC₅₀=55nM), CDK2/cyclin A (IC₅₀=35nM), CDK2/cyclin E (IC₅₀=150nM), CDK4/cyclin D1 (IC₅₀=300nM), CDK5/p35 (IC₅₀=65nM) and GSK-3β (IC₅₀=280nM).

Product Specific Literature References

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases: R. Hoessel, et al.; Nat. Cell. Biol. 1, 60 (1999)
Inhibitor binding to active and inactive cdk2. the crystal structure of cdk2-cyclin a/indirubin-5-sulphonate: T.G. Davies, et al.; Structure (Camb) 9, 389 (2001) Abstract
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells: D. Marko, et al.; Br. J. Cancer 84, 283 (2001) Abstract
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?: S. Leclerc, et al.; J. Biol. Chem. 276, 251 (2001) Abstract; Full Text

ALX-270-271	Indirubin-3'-monoxime
ALX-430-149	7BIO
ALX-270-361	Indirubin
ALX-270-424	5-Iodo-indirubin-3'-monoxime