ALEXIS Biochemicals: Indole-3-carbinol

ALX-350-347

Revised 21-May-08

Indole-3-carbinol
SYNONYMS	I3C Indole-3-methanol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-347-M250		250 mg	40.00 USD
ALX-350-347-G001		1 g	90.00 USD

Product Specification

FORMULA:	C₉H₉NO
MW:	147.2
CAS NUMBER:	700-06-1
RTECS:	NL9483000
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol; sparingly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.

Product Description

Anticancer agent. Inhibits carcinogenesis at the initiation stage but has been shown to enhance tumor incidence at a post-initiation stage. Inhibits the expression of cyclin-dependent kinase 6 (CDK6) and induces G1 cell cycle arrest independent of estrogen receptor signalling. Causes a dose-dependent increase in E-cadherin and BRCA1 expression.

Product Specific Literature References

Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles: L.W. Wattenberg & W.D. Loub; Cancer Res. 38, 1410 (1978) Abstract
Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling: C.M. Cover, et al.; J. Biol. Chem. 273, 3838 (1998) Abstract; Full Text
Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes: Q. Meng, et al.; J. Mol. Med. 78, 155 (2000) Abstract; Full Text
Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model: K.M. Rahman, et al.; Mol. Cancer Ther. 5, 2747 (2006) Abstract; Full Text
3,3’-Diindolylmethane stimulates murine immune function in vitro and in vivo: L. Xue, et al.; J. Nutr. Biochem. 19, 336 (2008) Abstract