ALEXIS Biochemicals: COX-2 (sheep)

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ALX-202-030

Revised 26-May-08

COX-1 (sheep)
SYNONYMS	Cyclooxygenase 1 (sheep) Prostaglandin H Synthase 1 (sheep)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	COX

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-202-030-UT50		5 KU	259.00 USD

Product Specification

MW:	~70kDa.
EC:	1.14.99.1
SOURCE/HOST:	Isolated from sheep seminal vesicles.
CONCENTRATION:
PURITY:	≥95%
FORMULATION:	Liquid. In 80mM TRIS/HCl, pH 8.0, containing 0.1% Tween 20 and 300µM DDC.
ACTIVITY:	~20'000U/ml.
SPECIFIC ACTIVITY:	≥45,000U/mg protein. One unit is defined as the amount of enzyme that consumes 1nmol oxygen per min. at 37°C in 0.1M TRIS/HCl, pH 8.0, containing 100µM arachidonate, 5mM EDTA, 2mM phenol and 1µM hematin.
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Enzyme is extremely unstable in the absence of preservative and should be used within 1 hour.

Product Specific Literature References

Prostaglandin H synthase: L.J. Marnett & K.R. Maddipati; 'Peroxidases in Biology, vol 1' (J. Everse, et al. eds.), CRC Press, Inc., Boca Raton 293 (1991)
Prostaglandin endoperoxide synthase: structure and catalysis: W.L. Smith & L.J. Marnett; Biochim. Biophys. Acta 1083, 1 (1991) Abstract
Prostaglandin endoperoxide synthase: regulation of enzyme expression: D.L. DeWitt; Biochim. Biophys. Acta 1083, 121 (1991) Abstract
Mitogen-Inducible Prostaglandin G/H Synthase: A New Target for Nonsteroidal Antiinflammatory Drugs: W. Xie, et al.; Drug Development Research 25, 249 (1992)

General Information

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P05979: COX-1 (sheep) (precursor)
AfCS Signalling Gateway link A000738: COX-1 (mouse)

Further Categories Containing This Product:

Enzymes • Natural Proteins

ALX-202-032

Revised 07-Oct-08

COX-2 (sheep)
SYNONYMS	Cyclooxygenase 2 (sheep) Prostaglandin H Synthase 2 (sheep)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	COX

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-202-032-UT10		1 KU	176.00 USD

Product Specification

MW:	~72kDa/subunit.
EC:	1.14.99.1
SOURCE/HOST:	Isolated from sheep placenta.
CONCENTRATION:
PURITY:	~70%
FORMULATION:	Liquid. In 80mM TRIS-HCl, pH 8.0, containing 0.1% Tween 20 and 300µM DDC.
ACTIVITY:	~4'000U/ml
SPECIFIC ACTIVITY:	~4'500U/mg protein. One unit is defined as the amount of enzyme that consumes 1nmol oxygen per min. at 37°C in 0.1M TRIS/HCl, pH 8.0, containing 100µM arachidonate, 5mM EDTA, 2mM phenol and 1µM hematin.
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Enzyme is extremely unstable after removal of preservative and should be used within 1 hour.
HANDLING:	Keep stock on ice while handling. After opening, prepare aliquots and store at -80°C.

Product Specific Literature References

The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s): J.H. Capdevila, et al.; Biochemistry 34, 3325 (1995) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P79208: COX-2 (sheep) (precursor)
AfCS Signalling Gateway link A000739: COX-2 (mouse)

Further Categories Containing This Product:

Enzymes • Natural Proteins

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