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Cyclooxygenases [COX] / Related Products
You are here: Product Lines > Inflammation > Cyclooxygenases [COX] / Related Products
 
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ALX-430-107 Revised 20-Aug-08
Sulindac sulfone
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-107-M005   5 mg 30.00 USD Add To Cart
ALX-430-107-M050   50 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H17FO4S
MW: 372.4
CAS NUMBER: 59864-04-9
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol (warm).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Metabolite of sulindac (Prod. No. ALX-430-105).
Product Specific Literature References
Sulindac inhibits activation of the NF-kappaB pathway: Y. Yamamoto, et al.; J. Biol. Chem. 274, 27307 (1999) Abstract; Full Text
Further Categories Containing This Product:
COX Inhibitors • NF-kB Pathway Inhibitors
 
 
ALX-350-261 Revised 07-Oct-08
Trichodion
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-261-C100   100 µg 85.00 USD Add To Cart
ALX-350-261-C500   500 µg 250.00 USD Add To Cart
Product Specification
FORMULA: C12H14O5
MW: 238.2
SOURCE/HOST: Isolated from Trichosporiella sp.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Cytotoxic. Inhibits NF-κB (IC50=42-84µM), AP-1 (IC50=21µM) and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS ll) expression.
Product Specific Literature References
Trichodion, a new inhibitor of inflammatory signal transduction pathways from a Trichosporiella species: G. Erkel; FEBS Lett. 477, 219 (2000) Abstract; Full Text
Trichodion, a new bioactive pyrone from a Trichosporiella species: G. Erkel, et al.; J. Antibiot. (Tokyo) 53, 1401 (2000) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Nitric Oxide Pathway Modulators • NF-kB Pathway Inhibitors • COX Inhibitors • Other Natural Products for Inflammation Research
 
 
ALX-270-360 Revised 21-May-08
Tryptanthrin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products for Inflammation Research
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ALX-270-360-M001   1 mg 50.00 USD Add To Cart
ALX-270-360-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C15H8N2O2
MW: 248.2
CAS NUMBER: 13220-57-0
SOURCE/HOST: Synthetic.
PURITY: ≥98% (1H-NMR, HPLC)
APPEARANCE: Yellow needles.
SOLUBILITY: Soluble in DMSO (8mg/ml) or methanol (0.3mg/ml); sparingly soluble in water (2.5µg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 2 years after receipt when stored at +4°C in the dark. Stock solutions made in DMSO must be stored in the dark no longer than one month.
HANDLING: Protect from light and moisture.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR, IR, MS and UV.

Product Description
Potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Selective inhibitor of cyclooxygenase 2 (COX-2). Inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Inhibits the production of IFN-γ and IL-2 after stimulation of Peyer’s patch lymphocytes with staphylococcal enterotoxin B (SEB). Inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin (Prod. No. ALX-380-042) resistance on breast cancer cells.
Product Specific Literature References
H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000)
Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med. 67, 411 (2001) Abstract
Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis: H. Danz, et al.; Planta Med. 68, 875 (2002) Abstract
Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages: T. Ishihara, et al.; Eur. J. Pharmacol. 407, 197 (2000) Abstract
Tryptanthrin inhibits interferon-gamma production by Peyer’s patch lymphocytes derived from mice that had been orally administered staphylococcal enterotoxin: Y. Takei, et al.; Biol. Pharm. Bull. 26, 365 (2003) Abstract
Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells: S.T. Yu, et al.; BBRC 358, 79 (2007) Abstract
General Information
Tryptanthrin occurs as a natural product in various plants, including Isatis tinctoria, I. indigotica, Polygonum tinctorium, Couroupita guianensis, Wrightia tinctoria and Calanthe discolor.
Further Categories Containing This Product:
Leukotrienes Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • Prostaglandins Other Products • COX Inhibitors • Natural Products - Nitric Oxide Pathway Modulators
 
 
ALX-270-194 Revised 19-Sep-05
Valeryl salicylate
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SYNONYMS 2-Valeryloxybenzoic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-194-M100   100 mg 51.00 USD Add To Cart
Product Specification
FORMULA: C12H14O4
MW: 222.2
CAS NUMBER: 64206-54-8
PURITY: ≥99%
APPEARANCE: White crystalline solid.
SOLUBILITY: Soluble in 100% ethanol (95mg/ml), methanol, DMSO (43mg/ml) or dimethyl formamide (70mg/ml); also soluble in PBS, pH 7.2 (6mg/ml)). Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Selective inhibitor of cyclooxygenase-1 (COX-1).
Product Specific Literature References
Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid: D.K. Bhattacharyya, et al.; Arch. Biochem. Biophys. 317, 19 (1995) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Further Categories Containing This Product:
COX Inhibitors
 
 
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