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Inflammation
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ALX-201-370 Revised 04-Jan-07
ST2 (human) (recombinant)
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SYNONYMS IL-1 Receptor-like 1 (human) (recombinant)
Interleukin-1 Receptor-like 1 (human) (recombinant)
IL1RL1 (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Interleukin Receptors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-370-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide and the sequence of isoform 2 of human ST2 (IL1RL1) (aa 1-328) are fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q01638: Interleukin-1 receptor-like 1 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • Interleukin-33 [IL-33] & Receptors/Related Products
 
 
ALX-201-377 Revised 06-May-08
Progranulin (human) (recombinant)
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SYNONYMS Proepithelin (human) (recombinant)
PEPI (human) (recombinant)
PC Cell-derived Growth Factor (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Progranulin/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-377-C010   10 µg 180.00 USD Add To Cart
ALX-201-377-C050   50 µg 480.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and mature human progranulin (aa 1-593) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P28799: Granulins (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990) Abstract
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003) Abstract
Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003) Abstract
Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review) Abstract; Full Text
Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • Inflammation Other Products
 
 
ALX-201-389 Revised 23-Apr-08
Progranulin (mouse) (recombinant)
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SYNONYMS Proepithelin (mouse) (recombinant)
PEPI (mouse) (recombinant)
PC Cell-derived Growth Factor (mouse) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Progranulin/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-389-C010   10 µg 295.00 USD Add To Cart
ALX-201-389-C050   50 µg 690.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and mature mouse progranulin (aa 1-589) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P28798: Granulins (mouse) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990) Abstract
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003) Abstract
Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003) Abstract
Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review) Abstract; Full Text
Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • Inflammation Other Products
 
 
ALX-201-402 Revised 27-Mar-08
SIGIRR (human):Fc (human) (recombinant)
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SYNONYMS Single Ig IL-1R-related Molecule (human):Fc (human) (recombinant)
TIR8 (human):Fc (human) (recombinant)
Toll/Interleukin-1 Receptor 8 (human):Fc (human) (recombinant)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Interleukin-1 [IL-1] & Receptors/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-402-C010   10 µg 260.00 USD Add To Cart
ALX-201-402-C050   50 µg 560.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q6IA17: SIGIRR (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • Proteasome/Related Products
 
 
ALX-201-408 Revised 27-Mar-08
Ribosomal Protein S3 (human) (recombinant) (His)
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SYNONYMS RPS3 (human) (recombinant) (His)
40S Ribosomal Protein S3
IMR-90 Ribosomal Protein S3
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Ribosomal Proteins/Related Products
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ALX-201-408-C010   10 µg 330.00 USD Add To Cart
ALX-201-408-C050   50 µg 740.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Mature peptide of human ribosomal protein S3 (aa 1-243) is fused at the C-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 25mM TRIS-HCl, pH 8.5, containing 1mM DTT.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation: T.S. Kim, et al.; Mol. Biol. Cell 17, 824 (2006) Abstract; Full Text
Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK: S.H. Kim & J. Kim; Biochim. Biophys. Acta 1763, 823 (2006) Abstract
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation: F. Wan, et al.; Cell 131, 927 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P23396: Ribosomal Protein S3 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins/Related Products • Recombinant Proteins/Fusion Proteins • DNA Endonucleases/Related Products • NF-kB Pathway Other Products • MAPK Pathway Other Products
 
 
ALX-201-410 Revised 13-Feb-08
Ribosomal Protein S3 (human) (recombinant)
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PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Ribosomal Proteins/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-410-C010   10 µg 330.00 USD Add To Cart
ALX-201-410-C050   50 µg 740.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The mature peptide of human ribosomal protein S3 (aa 1-243) is fused at the N-terminus to a tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 25mM TRIS-HCl, pH 8.5, containing 1mM DTT.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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Product Specific Literature References
Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation: T.S. Kim, et al.; Mol. Biol. Cell 174, 824 (2006) Abstract; Full Text
Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK: S.H. Kim & J. Kim; Biochim. Biophys. Acta 1763, 823 (2006) Abstract
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation: F. Wan, et al.; Cell 131, 927 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P23396: Ribosomal Protein S3 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins/Related Products • Recombinant Proteins/Fusion Proteins • DNA Endonucleases/Related Products • NF-kB Pathway Other Products • MAPK Pathway Other Products
 
 
ALX-202-030 Revised 26-May-08
COX-1 (sheep)
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SYNONYMS Cyclooxygenase 1 (sheep)
Prostaglandin H Synthase 1 (sheep)
PRODUCT LINE Inflammation
PRODUCT CATEGORY COX
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-202-030-UT50   5 KU 259.00 USD Add To Cart
Product Specification
MW: ~70kDa.
EC: 1.14.99.1
SOURCE/HOST: Isolated from sheep seminal vesicles.
CONCENTRATION:

PURITY: ≥95%
FORMULATION: Liquid. In 80mM TRIS/HCl, pH 8.0, containing 0.1% Tween 20 and 300µM DDC.
ACTIVITY: ~20'000U/ml.
SPECIFIC ACTIVITY: ≥45,000U/mg protein. One unit is defined as the amount of enzyme that consumes 1nmol oxygen per min. at 37°C in 0.1M TRIS/HCl, pH 8.0, containing 100µM arachidonate, 5mM EDTA, 2mM phenol and 1µM hematin.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Enzyme is extremely unstable in the absence of preservative and should be used within 1 hour.
Product Specific Literature References
Prostaglandin H synthase: L.J. Marnett & K.R. Maddipati; 'Peroxidases in Biology, vol 1' (J. Everse, et al. eds.), CRC Press, Inc., Boca Raton 293 (1991)
Prostaglandin endoperoxide synthase: structure and catalysis: W.L. Smith & L.J. Marnett; Biochim. Biophys. Acta 1083, 1 (1991) Abstract
Prostaglandin endoperoxide synthase: regulation of enzyme expression: D.L. DeWitt; Biochim. Biophys. Acta 1083, 121 (1991) Abstract
Mitogen-Inducible Prostaglandin  G/H Synthase: A New Target for Nonsteroidal Antiinflammatory Drugs: W. Xie, et al.; Drug Development Research 25, 249 (1992)
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P05979: COX-1 (sheep) (precursor)
AfCS Signalling Gateway link A000738: COX-1 (mouse)
Further Categories Containing This Product:
Enzymes • Natural Proteins
 
 
ALX-202-032 Revised 24-Apr-06
COX-2 (sheep)
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SYNONYMS Cyclooxygenase 2 (sheep)
Prostaglandin H Synthase 2 (sheep)
PRODUCT LINE Inflammation
PRODUCT CATEGORY COX
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-202-032-UT10   1 KU 176.00 USD Add To Cart
Product Specification
MW: ~72kDa/subunit.
EC: 1.14.99.1
SOURCE/HOST: Isolated from sheep placenta.
CONCENTRATION:     
PURITY: ~70%
FORMULATION: Liquid. In 80mM TRIS-HCl, pH 8.0 with 0.1% Tween 20 and 300µM DDC.
ACTIVITY: ~4'000U/ml
SPECIFIC ACTIVITY: ~4'500U/mg protein. One unit is defined as the amount of enzyme that consumes 1nmol oxygen per min. at 37°C in 0.1M TRIS/HCl, pH 8.0, containing 100µM arachidonate, 5mM EDTA, 2mM phenol and 1µM hematin.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Enzyme is extremely unstable after removal of preservative and should be used within 1 hour.
HANDLING: Keep stock on ice while handling. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s): J.H. Capdevila, et al.; Biochemistry 34, 3325 (1995) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P79208: COX-2 (sheep) (precursor)
AfCS Signalling Gateway link A000739: COX-2 (mouse)
Further Categories Containing This Product:
Enzymes • Natural Proteins
 
 
ALX-210-012 Revised 29-Jun-05
Polyclonal Antibody to Caspase-6 (human)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-012-R050   50 µl 190.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN: Recombinant human caspase-6 (catalytic subunit).
SPECIFICITY: Recognizes human caspase-6. Detects both procaspase-6 and active caspase-6.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3: T. Miyashita, et al.; Cell Death Differ. 5, 1034 (1998) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-013 Revised 29-Jun-05
Polyclonal Antibody to Caspase-7 (human)