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ALX-350-138
Revised 05-Dec-06
Hexaprenylhydroquinone
SYNONYMS
HPH
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antiviral/anti-HIV Agents
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ALX-350-138-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
36
H
54
O
2
MW:
518.8
CAS NUMBER:
119980-00-6
SOURCE/HOST:
Isolated from
Sarcotragus
sp.
PURITY:
≥97% (HPLC)
APPEARANCE:
Off-white to brown solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by MS,
1
H-NMR.
Product Description
Potent inhibitor of HIV reverse transcriptase and cellular DNA polymerase. Inhibitor of CDC25A. Similar compounds have shown inhibitory effects on phospholipase A2.
Product Specific Literature References
Three new heptaprenylhydroquinone derivatives from the sponge Ircinia fasciculata:
Y. Venkateswarlu and M. Venkata Rami Reddy; J. Nat. Prod.
57
, 1286 (1994)
Biological effects of prenylated hydroquinones: structure-activity relationship studies in antimicrobial, brine shrimp, and fish lethality assays:
S. De Rosa, et al.; J. Nat. Prod.
57
, 1711 (1994)
Abstract
Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases:
S. Loya, et al.; Biochem. J.
324
, 721 (1997)
Abstract
;
Full Text
Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A:
I. Erdogan-Orhan, et al.; Nat. Prod. Res.
18
, 1 (2004)
Abstract
General Literature References
Effects of marine 2-polyprenyl-1,4-hydroquinones on phospholipase A2 activity and some inflammatory responses:
B. Gil, et al.; Eur. J. Pharmacol.
285
, 281 (1995)
Abstract
Further Categories Containing This Product:
PLA2 Inhibitors
•
Natural Products - DNA Replication Inhibitors
•
HIV/AIDS/Related Products
ALX-350-234
Revised 08-Apr-08
12-epi-Scalaradial
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-234-M001
1 mg
190.00 USD
Product Specification
FORMULA:
C
27
H
40
O
4
MW:
428.6
CAS NUMBER:
53527-28-9
SOURCE/HOST:
Isolated from
Cacospongia sp.
PURITY:
≥98%
APPEARANCE:
Waxy solid.
SOLUBILITY:
Soluble in acetic acid, 100% ethanol or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of bee venom phospholipase A
2
(PLA
2
). Inhibits Ca
2+
mobilization induced by leukotriene B
4
(LTB
4
) and platelet activating factor. Inhibits Ca
2+
-dependent arachidonic acid release in human neutrophils. Inhibits epidermal growth factor (EGF)-stimulated Akt (protein kinase B; PKB) phosphorylation.
Product Specific Literature References
Two-step inactivation of bee venom phospholipase A2 by scalaradial:
M.S. De Carvalho & R.S. Jacobs; Biochem. Pharmacol.
42
, 1621 (1991)
Abstract
Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils:
J.D. Winkler, et al.; Biochem. Pharmacol.
44
, 2055 (1992)
Abstract
Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation:
L.A. Marshall, et al.; J. Pharmacol. Exp. Ther.
268
, 709 (1994)
Abstract
Scalaradial inhibition of epidermal growth factor receptor-mediated Akt phosphorylation is independent of secretory phospholipase A2:
Y. Xie, et al.; J. Pharmacol. Exp. Ther.
314
, 1210 (2005)
Abstract
Scalaradial, a dialdehyde-containing marine metabolite that causes an unexpected noncovalent PLA2 Inactivation:
M.C. Monti, et al.; Chembiochem
8
, 1585 (2007)
Abstract
Further Categories Containing This Product:
PLA2 Inhibitors
•
Akt [PKB]/Related Products
•
Calcium Signalling (Intracellular) Other Products
ALX-370-006
Revised 03-Jun-08
U-73343
SYNONYMS
1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-pyrrolidine-2,5-dione
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PLA2 Inhibitors
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ALX-370-006-M001
1 mg
20.00 USD
ALX-370-006-M005
5 mg
80.00 USD
Product Specification
FORMULA:
C
29
H
42
N
2
O
3
MW:
466.7
CAS NUMBER:
142878-12-4
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in methylene chloride or chloroform; slightly soluble in DMSO or 100% ethanol; sparingly soluble in aqueous solutions.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
USE/STABILITY:
Stock solutions in DMSO or ethanol are stable for 4 months when stored at -20°C.
Product Description
Analog of U-73122 (Prod. No.
ALX-370-005
) which only slightly inhibits phospholipase C. Useful as a negative control.
Product Specific Literature References
Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness:
R.J. Smith, et al.; J. Pharmacol. Exp. Ther.
253
, 688 (1990)
Abstract
Gonadotropin-releasing hormone-stimulated intracellular Ca2+ fluctuations and luteinizing hormone release can be uncoupled from inositol phosphate production:
B.E. Hawes, et al.; Endocrinology
130
, 3475 (1992)
Abstract
A new, nongenomic estrogen action: the rapid release of intracellular calcium:
P Morley, et al.; Endocrinology
131
, 1305 (1992)
Abstract
U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells:
A. Tatrai, et al.; Biochim. Biophys. Acta
1224
, 575 (1994)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Preparation of Working Solutions
Compound is only sparingly soluble in aqueous media and may be delivered to cells either after dissolving in organic solvents or complexing with serum proteins. Dissolve a weighed amount in methylene chloride or chloroform. Dispense in aliquots sufficient for one experiment into suitable vessels. Evaporate the solvent with a stream of nitrogen. This leaves a thin, dry film, which may be easily dissolved in DMSO (~5mM) or 100% ethanol (~2mM). As an alternative, an aqueous medium that contains serum or serum albumin (1-10mg/ml) may be used to dissolve the thin film.
Related Products
ALX-370-005
U-73122
Further Categories Containing This Product:
Phospholipase C/Related Products
ALX-420-043
Revised 22-May-08
FTY720
SYNONYMS
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol . HCl
Fingolimod . HCl
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Immunomodulators Other Products
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ALX-420-043-M001
1 mg
40.00 USD
ALX-420-043-M005
5 mg
190.00 USD
Product Specification
FORMULA:
C
19
H
33
NO
2
. HCl
MW:
307.5 . 36.5
CAS NUMBER:
162359-56-0
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
20mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; sparingly soluble in aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
We do not recommend storing aqueous solutions for more than one day.
Product Description
Analog of myriocin (Prod. No.
ALX-350-274
). Novel immune modulator that alters migration and homing of lymphocytes. Acts as a potent agonist of sphingosine 1-phosphate receptors (S1P) after phosphorylation by sphingosine kinase. Also inhibits cytosolic phospholipase A
2
independently of sphingosine 1-phosphate receptors.
Product Specific Literature References
The immune modulator FTY720 targets sphingosine 1-phosphate receptors:
V. Brinkmann, et al.; J. Biol. Chem.
277
, 21453 (2002)
Abstract
;
Full Text
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors:
S.G. Payne, et al.; Blood
109
, 1077 (2007)
Abstract
FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia:
P. Neviani, et al.; J. Clin. Invest.
117
, 2408 (2007)
Abstract
;
Full Text
Related Products
ALX-350-274
Myriocin
Further Categories Containing This Product:
PLA2 Inhibitors
ALX-300-097
Revised 09-Dec-04
1,2-Dimyristoyl-sn-glycero-3-phosphomethanol . sodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids/Related Products
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ALX-300-097-M050
50 mg
30.00 USD
ALX-300-097-M250
250 mg
90.00 USD
Product Specification
FORMULA:
C
32
H
62
O
8
P . Na
MW:
605.8 . 23.0
PURITY:
≥99%
APPEARANCE:
Off-white solid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for kinetic studies of phospholipase A
2
.
Product Specific Literature References
Kinetics of interfacial catalysis by phospholipase A2 in intravesicle scooting mode, and heterofusion of anionic and zwitterionic vesicles:
M.K. Jain, et al.; Biochim. Biophys. Acta
860
, 435 (1986)
Abstract
Competitive inhibition of phospholipase A2 in vesicles:
M.K. Jain, et al.; Biochemistry
28
, 4135 (1989)
Abstract
Active-site-directed specific competitive inhibitors of phospholipase A2: novel transition-state analogues:
M.K. Jain, et al.; Biochemistry
30
, 10256 (1991)
Abstract
Further Categories Containing This Product:
PLA2 Substrates
ALX-300-101
Revised 09-Dec-04
1-O-Oleyl-2-O-hexadecyl-rac-glycero-3-phosphocholine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids/Related Products
Ordering Information
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ALX-300-101-M050
50 mg
80.00 USD
ALX-300-101-M250
250 mg
320.00 USD
Product Specification
FORMULA:
C
42
H
86
NO
6
P
MW:
732.1
PURITY:
≥99%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Rapid purification of phospholipase A2 from Crotalus adamanteus venom by affinity chromatography:
C.O. Rock & F. Snyder; J. Biol. Chem.
250
, 6564 (1975)
Abstract
;
Full Text
Isolation of homogeneous phospholipase A2 from human platelets:
R.J. Apitz-Castro, et al.; BBRC
91
, 63 (1979)
Abstract
Isolation of phospholipase A2 from red cell membranes of sheep:
P. Zahler & R. Kramer; Meth. Enzymol.
71
, 690 (1981)
Abstract
Further Categories Containing This Product:
PLA2 Substrates
ALX-300-140
Revised 08-Jul-08
1,2-bis(Heptanoylthio)glycerophosphocholine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Lipid Signalling Pathways Other Products
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ALX-300-140-M005
5 mg
215.00 USD
Product Specification
FORMULA:
C
22
H
44
NO
6
PS
2
MW:
513.7
CAS NUMBER:
89019-63-6
PURITY:
≥95%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
50 mg/ml soluble in DMSO or dimethyl formamide; sparingly soluble in PBS, pH 7.2 (62μg/ml).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Product Description
Substrate for the general assay of phospholipases, except Ca
2+
-dependent cytosolic phospholipase A
2
(cPLA
2
). PLA
2
hydrolyzes the
sn
-2 position of the phospholipid thiol groups. The released thiol can be estimated colorimetrically using Ellman's reagent (DTNB, Prod. No.
ALX-400-034
). For an assay kit for secretory PLA
2
(sPLA
2
) based on this substrate see Prod. No.
ALX-850-007
. For a substrate for cPLA
2
see Arachidonoyl Thio-PC (Prod. No.
ALX-300-141
).
Product Specific Literature References
Analysis of human synovial fluid phospholipase A2 on short chain phosphatidylcholine-mixed micelles: development of a spectrophotometric assay suitable for a microtiterplate reader:
L.J. Reynolds, et al.; Anal. Biochem.
204
, 190 (1992)
Abstract
Thio-based phospholipase assay:
L. Yu & E.A. Dennis; Meth. Enzymol.
197
, 65 (1991)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. Avoid dissolving 1,2-bis(Heptanoylthio)glycerophosphocholine in basic solutions, since base treatment promotes hydrolysis of the thioester. Triton X-100 will enhance the solubility significantly. The critical micellar concentration of 1,2-bis(Heptanoylthio)glycerophosphocholine 0.17mM in 0.2M Tris-maleate buffer, pH 7.4.
Further Categories Containing This Product:
PLA2 Substrates
ALX-300-141
Revised 07-Jul-08
Arachidonoyl Thio-PC
SYNONYMS
2-Deoxy-2-thioarachidonoylphosphatidylcholine
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phospholipids/Related Products
Ordering Information
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ALX-300-141-M005
5 mg
189.00 USD
Product Specification
FORMULA:
C
44
H
82
NO
6
PS
MW:
784.2
CAS NUMBER:
146797-82-2
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol containing 0.1% BHT.
SOLUBILITY:
Soluble in methanol, DMSO or dimethyl formamide; slightly soluble in water (0.5 mg/ml).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at –20°C.
Product Description
Substrate for all forms of phospholipase A
2
(PLA
2
) including the cytosolic, Ca
2+
-dependent form (cPLA
2
). Upon hydrolysis of the thioester bond, free thiols are detected using DTNB (Ellmans reagent) (Prod. No.
ALX-400-034
). For an assay kit for cPLA
2
based on this product see Prod. No.
ALX-850-009
.
Product Specific Literature References
1-Hexadecyl-2-arachidonoylthio-2-deoxy-sn-glycero-3-phosphorylcholine as a substrate for the microtiterplate assay of human cytosolic phospholipase A2:
L.J. Reynolds, et al.; Anal. Biochem.
217
, 25 (1994)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. Addition of Triton X-100 will enhance the solubility significantly. The critical micellar concentration of Arachidonoyl Thio-PC is 2mM in 8mM Hepes (pH 7.4), 150mM NaCl, 10mM CaCl
2
, 4mM Triton X-100, 30% glycerol and 1mg/ml BSA.
Further Categories Containing This Product:
PLA2 Substrates
ALX-340-018
Revised 08-Jul-08
Umbelliferyl arachidonate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PLA2 Substrates
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ALX-340-018-M010
10 mg
87.00 USD
Product Specification
FORMULA:
C
29
H
36
O
MW:
448.6
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in DMSO (25mg/ml) or dimethyl formamide (50mg/ml); 50μg/ml soluble in a 1:1 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
Product Description
Fluorometric substrate for the measurement of phospholipase A
2
(PLA
2
) activity.
Product Specific Literature References
A continuous fluorescence-based assay for the human high-molecular- weight cytosolic phospholipase A2:
Z. Huang, et al.; Anal. Biochem.
222
, 110 (1994)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
ALX-301-001
Revised 09-Dec-04
PAF (C16)
SYNONYMS
1-O-Hexadecyl-2-acetyl-
sn
-glycero-3-phosphocholine
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Platelet Activating Factors [PAF] & Receptors/Related Products
Ordering Information
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ALX-301-001-M001
1 mg
15.00 USD
ALX-301-001-M005
5 mg
40.00 USD
ALX-301-001-M025
25 mg
145.00 USD
ALX-301-001-M100
100 mg
300.00 USD
Product Specification
FORMULA:
