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ALX-804-307
Revised 19-Sep-05
Monoclonal Antibody to Caspase-6 (human) (B93-4)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-307-C100
100 µg
450.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
B93-4
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G affinity-purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 271-285 of human caspase-6. This sequence is not identical in mouse and rat.
SPECIFICITY:
Recognizes human procaspase-6 and active human caspase-6. Detects bands of ~34kDa (procaspase-6) and 11kDa (active caspase-6) by Western blot.
APPLICATION:
Western Blot (1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for 6 months when stored at +4°C.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-242
Revised 30-Sep-08
Monoclonal Antibody to Caspase-8 (human) (12F5)
SYNONYMS
anti-FLICE (human) MAb (12F5)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-242-C100
100 µg
350.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
12F5
ISOTYPE:
Mouse IgG2b
CONCENTRATION:
1mg/ml
PURITY:
≥97% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In 0.15M PBS, pH 7.2, containing 1% BSA and 0.01% thimerosal.
IMMUNOGEN:
Recombinant human caspase-8.
SPECIFICITY:
Recognizes human procaspase-8 and active human caspase-8. Detects procaspase-8 (p55/54), the intermediate cleavage products (p43/41) and the p18 active subunit of caspase-8 by Western blot. Does not recognize mouse caspase-8.
APPLICATION:
Immunoprecipitation
Western Blot (1:500-1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis:
D. Ferrari, et al.; J. Exp. Med.
188
, 979 (1998)
Abstract
;
Full Text
Sendai virus infection induces apoptosis through activation of caspase-8 (FLICE) and caspase-3 (CPP32):
M. Bitzer, et al.; J. Virol.
73
, 702 (1999)
Abstract
;
Full Text
P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death:
D. Ferrari, et al.; FEBS Lett.
447
, 71 (1999)
Abstract
Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction:
S. Wesselborg, et al.; Blood
93
, 3053 (1999)
Abstract
;
Full Text
IL-10 induces apoptosis in human monocytes involving the CD95 receptor/ligand pathway:
M. Schmidt, et al.; Eur. J. Immunol.
30
, 1769 (2000)
Abstract
Inhibition of death receptor-mediated gene induction by a cycloheximide-sensitive factor occurs at the level of or upstream of Fas-associated death domain protein (FADD):
H. Wajant, et al.; J. Biol. Chem.
275
, 24357 (2000)
Abstract
;
Full Text
Trail-induced apoptosis in Type I leukemic cells is not enhanced by overexpression of bax:
L. Jia, et al.; BBRC
283
, 1037 (2001)
Abstract
Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway
:
D. Siegmund, et al.; J. Biol. Chem.
276
, 32585 (2001)
Abstract
;
Full Text
An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis:
Y. Kim, et al.; J. Biol. Chem.
277
, 22320 (2002)
Abstract
;
Full Text
Constitutive caspase activation and impaired death-inducing signaling complex formation in CD95-resistant, long-term activated, antigen-specific T cells:
G. Strauss, et al.; J. Immunol.
171
, 1172 (2003)
Abstract
;
Full Text
A Protective Role for the Human SMG-1 Kinase against Tumor Necrosis Factor-α-induced Apoptosis:
V. Oliveira, et al.; J. Biol. Chem.
283
, 13174 (2008)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-429
Revised 18-Sep-07
Monoclonal Antibody to Caspase-8 (human) (C15)
SYNONYMS
anti-FLICE (human) MAb (C15)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-429-C050
50 µg
195.00 USD
ALX-804-429-C100
100 µg
325.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
C15
ISOTYPE:
Mouse IgG2b
SOURCE/HOST:
The antibody was purified from hybridoma tissue culture supernatant.
CONCENTRATION:
0.5mg/ml
PURITY:
≥95% (SDS-PAGE).
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human caspase-8 (aa 181-478).
SPECIFICITY:
Recognizes the p18 subunit of human caspase-8.
APPLICATION:
Immunocytochemistry
Immunoprecipitation
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b
:
C. Scaffidi, et al.; J. Biol. Chem.
272
, 26953 (1997)
Abstract
;
Full Text
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
:
M.R. Sprick, et al.; EMBO J.
21
, 4520 (2002)
Abstract
Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation
:
M. Leverkus, et al.; Mol. Cell. Biol.
23
, 777 (2003)
Abstract
;
Full Text
Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice
:
S.T. Eichhorst, et al.; Nature Med.
10
, 602 (2004)
Abstract
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs
:
T.M. Ganten, et al.; Cell Death Differ.
11 Suppl 1
, S86 (2004)
Abstract
cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes:
T. Wachter, et al.; J. Biol. Chem.
279
, 52824 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-447
Revised 14-Aug-07
Monoclonal Antibody to Caspase-8 (mouse) (1G12)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-447-C100
100 µg
298.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
1G12
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse caspase-8 p18 subunit .
SPECIFICITY:
Recognizes the p18 subunit of mouse caspase-8. Detects bands of ~55kDa (full-length caspase-8) and ~18kDa (apoptosis-induced cleavage fragment) by Western blot. Does not cross-react with human caspase-8.
APPLICATION:
ELISA (recombinant mouse caspase-8)
Flow Cytometry (overexpressed caspase-8)
Immunocytochemistry
Western Blot (excellent)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. For long-term storage, aliquot and freeze at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes
:
L.A. O'Reilly; Cell Death Differ.
11
, 724 (2004)
Abstract
;
Full Text
Caspase-8 serves both apoptotic and nonapoptotic roles
:
T.B. Kang, et al.; J. Immunol.
173
, 2976 (2004)
Abstract
;
Full Text
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death:
V.S. Marsden, et al.; Blood
107
, 1872 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-448
Revised 31-Oct-06
Monoclonal Antibody to Caspase-8 (mouse) (3B10)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-448-C100
100 µg
298.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
3B10
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant mouse caspase-8 p18 subunit.
SPECIFICITY:
Recognizes mouse caspase-8. Detects bands of ~55kDa (full-length caspase-8) and ~18kDa (apoptosis-induced cleavage fragment) by Western blot. Does not cross-react with human caspase-8.
APPLICATION:
ELISA (recombinant mouse caspase-8)
Flow Cytometry (overexpressed caspase-8)
Immunocytochemistry (excellent)
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. For long-term storage, aliquot and freeze at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes
:
L.A. O'Reilly; Cell Death Differ.
11
, 724 (2004)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-507
Revised 14-Aug-07
Monoclonal Antibody to Caspase-11 (mouse) (4E11)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-507-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
CLONE:
4E11
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
p20 fragment of mouse caspase-11.
SPECIFICITY:
Recognizes mouse and rat caspase-11 (epitope in the p20 fragment). Detects two bands of ~38kDa and ~43kDa by Western blot.
APPLICATION:
Flow Cytometry
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death:
V.S. Marsden, et al.; Blood
107
, 1872 (2006)
Abstract
;
Full Text
General Information
Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. Human caspase-4, thought to be the homolog of mouse caspase-11, may be an effective therapeutic target for treatment of septic shock.
General Literature References
Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway
:
J. Hur, et al.; FEBS Lett.
507
, 157 (2001)
Abstract
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response
:
S.J. Kang, et al.; Cell Death Differ.
9
, 1115 (2002)
Abstract
Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1
:
R. Schauvliege, et al.; J. Biol. Chem.
277
, 41624 (2002)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-494
Revised 08-Jul-08
Monoclonal Antibody to Caspase-11 (mouse) (8A5)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-494-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
CLONE:
8A5
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
p20 fragment of mouse caspase-11.
SPECIFICITY:
Recognizes mouse and rat caspase-11 (epitope in the p20 fragment). Detects two bands of ~38kDa and ~43kDa by Western blot.
APPLICATION:
Flow Cytometry, Western blot.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
General Information
Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. Human caspase-4, thought to be the homolog of mouse caspase-11, may be an effective therapeutic target for treatment of septic shock.
General Literature References
Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway
:
J. Hur, et al.; FEBS Lett.
507
, 157 (2001)
Abstract
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response
:
S.J. Kang, et al.; Cell Death Differ.
9
, 1115 (2002)
Abstract
Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1
:
R. Schauvliege, et al.; J. Biol. Chem.
277
, 41624 (2002)
Abstract
;
Full Text
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-509
Revised 14-Aug-07
Monoclonal Antibody to Caspase-12 (mouse) (11F10)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-509-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
11F10
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
p20 fragment of mouse caspase-12 and synthetic peptide corresponding to aa 183-205 (N
183
KKFDYLFDRDNADTDILNMQEL
205
) of mouse caspase-12.
SPECIFICITY:
Recognizes an epitope within the p20 fragment of mouse caspase-12. Detects a band of ~51kDa by Western blot. Does not cross-react with mouse caspase-1 or -11.
APPLICATION:
ELISA
Flow Cytometry
Western Blot
Other applications not tested.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death:
V.S. Marsden, et al.; Blood
107
, 1872 (2006)
Abstract
;
Full Text
General Information
Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localised to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues; and is expressed at high levels in skeletal muscle, heart, lung and kidney, and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
Monoclonal Antibodies
ALX-804-511
Revised 10-Mar-06
Monoclonal Antibody to Caspase-12 (mouse) (12G6)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-511-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
12G6
ISOTYPE:
Rat IgG1
CONCENTRATION:
1mg/ml.
FORMULATION:
Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:
p20 fragment of mouse caspase-12 and synthetic peptide corresponding to aa 183-205 (N
183
KKFDYLFDRDNADTDILNMQEL
205
) of mouse caspase-12.
SPECIFICITY:
Recognizes an epitope within the p20 fragment of mouse caspase-12. Detects a band of ~51kDa by Western blot. Does not cross-react with mouse caspase-1 or -11.
APPLICATION:
ELISA
Flow Cytometry
Western Blot
Other applications not tested.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localised to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues; and is expressed at high levels in skeletal muscle, heart, lung and kidney, and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
Monoclonal Antibodies
ALX-804-228
Revised 19-Sep-05
Monoclonal Antibody to Caspase-14 (mouse) (70A1426)
